CAS 14976-57-9

Fumarato di clemastina

Descrizione:

Fumarato di clemastina è un farmaco antistaminico utilizzato principalmente per alleviare i sintomi allergici, come naso che cola, starnuti e prurito. È classificato come un antistaminico di prima generazione, il che significa che può attraversare la barriera ematoencefalica, portando spesso a effetti sedativi. La sostanza è un sale formato da clemastina, un derivato del diphenylmethanol, e acido fumarico. Nella sua forma pura, Fumarato di clemastina appare come una polvere cristallina bianca o bianco sporco, solubile in acqua e alcol. Il suo meccanismo d'azione implica l'antagonismo dei recettori dell'istamina H1, inibendo così gli effetti dell'istamina, un composto coinvolto nelle risposte allergiche. Inoltre, Fumarato di clemastina può mostrare proprietà anticolinergiche, contribuendo alla sua efficacia nell'alleviare i sintomi. Il composto è tipicamente somministrato per via orale ed è disponibile in varie formulazioni, tra cui compresse e sciroppi. Come con molti antistaminici, gli effetti collaterali potenziali possono includere sonnolenza, secchezza delle fauci e vertigini, richiedendo cautela durante la guida o l'uso di macchinari pesanti.

Formula: C₂₁H₂₆ClNO·C₄H₄O₄

InChI: InChI=1/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1

SMILES: [C@@](OCC[C@@H]1N(C)CCC1)(C)(C2=CC=C(Cl)C=C2)C3=CC=CC=C3.C(=C/C(O)=O)\C(O)=O

Sinonimi:

• (+)-(2R)-2-[2-[[(R)-p-Chloro-alpha-methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine
• (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate
• (2R)-2-[2-[(1R)-1-(4-Chlorophenylethoxy)]Ethyl]-1-Methyl-2-Pyrrolidine Fumarate
• (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine
• (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine (2E)-but-2-enedioate
• 2-{2-[1-(4-Chlorophenyl)-1-Phenylethoxy]Ethyl}-1-Methylpyrrolidine
• Agasten
• Aloginan
• Alphamin
• Anhistan
• Bravegyl
• Clemastine
• Clemastine Fumarate Salt
• Clemastine Hydrogen Fumarate
• Clemastinum
• Fuluminol
• Hs 592
• Inbestan
• Kinotomin
• Lacretin
• Lecasol
• Maikohis
• Mallermin F
• Marsthine
• Masletine
• Meclastine fumarate
• Mecloprodine
• Piloral
• Pyrrolidine, 2-2-(1R)-1-(4-chlorophenyl)-1-phenylethoxyethyl-1-methyl-, (2R)-
• Pyrrolidine, 2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, (2R)-, (2E)-2-butenedioate (1:1)
• Pyrrolidine, 2-[2-[(p-chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methyl-, (+)- (8CI)
• Pyrrolidine, 2-[2-[(p-chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methyl-, (+)-, fumarate (1:1)
• Pyrrolidine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, [R-(R*,R*)]-
• Pyrrolidine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, [R-(R*,R*)]-, (E)-2-butenedioate (1:1)
• Reconin
• Tavegil
• Tavegyl
• Tavist
• Telgin
• Telgin G
• Trabest
• Xolamin

Clemastine Fumarate

CAS: 14976-57-9

Formula: C₂₁H₂₆ClNO·C₄H₄O₄

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 459.97

Ref: 3B-C3816

Clemastine Fumarate

CAS: 14976-57-9

Colore e forma: Neat

Ref: 61-FOR1444.00

CLEMASTINE FUMARATE CRS

CAS: 14976-57-9

CLEMASTINE FUMARATE CRS

Formula: C₂₅H₃₀ClNO₅

Colore e forma: Crystalline Powder. White. Powder.

Peso molecolare: 459.9624

Ref: 41-C2223000

CLEMASTINE FOR SYSTEM SUITABILITY CRS

CAS: 14976-57-9

CLEMASTINE FOR SYSTEM SUITABILITY CRS

Formula: C₂₅H₃₀ClNO₅

Peso molecolare: 459.9624

Ref: 41-Y0001613

Clemastine fumarate

CAS: 14976-57-9

Clemastine fumarate

Formula: C₂₁H₂₆ClNO

Purezza: 74.7%

Colore e forma: White

Peso molecolare: 343.17029

Ref: 47-525

(2E)-but-2-enedioic acid; (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine

CAS: 14976-57-9

Formula: C₂₅H₃₀ClNO₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 459.9624

Ref: IN-DA00HXQN

Clemastine fumarate

CAS: 14976-57-9

Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.

Formula: C₂₅H₃₀ClNO₅

Purezza: 99.52% - >99.99%

Colore e forma: Colorless To Faintly Yellow Crystalline Powder Appearance White Or Almost White Crystalline Powder

Peso molecolare: 459.97

Ref: TM-T0147

Clemastine fumarate

CAS: 14976-57-9

Clemastine fumarate

Purezza: ≥98%

Peso molecolare: 459.97g/mol

Ref: 54-BUP14783

(R)-2-(2-((R)-1-(4-Chlorophenyl)-1-Phenylethoxy)Ethyl)-1-Methylpyrrolidine Fumarate

CAS: 14976-57-9

(R)-2-(2-((R)-1-(4-Chlorophenyl)-1-Phenylethoxy)Ethyl)-1-Methylpyrrolidine Fumarate

Purezza: 99%

Peso molecolare: 459.96g/mol

Ref: 54-OR1008447

Clemastine Fumarate

CAS: 14976-57-9

Formula: C₂₁H₂₆ClNO·C₄H₄O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 343.90 116.07

Ref: 4Z-C-144001

Clemastine Fumarate

Prodotto controllato

CAS: 14976-57-9

Formula: C₂₁H₂₆ClNO·C₄H₄O₄

Colore e forma: Neat

Peso molecolare: 459.96

Ref: 86-MM1444.00

Clemastine fumarate

CAS: 14976-57-9

Purezza: 98%

Peso molecolare: 459.970

Ref: 10-F859378

Clemastine Fumarate

Prodotto controllato

CAS: 14976-57-9

Applications H1 Histamine receptor antagonist. Antihistaminic.
References Weidmann, et al.: Boll. Chim. Farm., 106, 467 (1967), Gober, B., et al.: Pharmazie, 43, 539 (1988), Breccia, A., et al.: Curr. Ther. Res., 49, 622 (1991), Schran, H., et al.: J. Clin. Pharmacol., 36, 911 (1996),

Formula: C₂₁H₂₆ClNO·C₄H₄O₄

Colore e forma: White

Peso molecolare: 459.96

Ref: TR-C568500

Clemastine-d5 Fumarate

Prodotto controllato

CAS: 14976-57-9

Formula: C₂₁D₅H₂₁ClNO·C₄H₄O₄

Colore e forma: Neat

Peso molecolare: 464.993

Ref: TR-C568502

Clemastine Fumarate

CAS: 14976-57-9

Antihistamines

Formula: C₂₁H₂₆ClNO·C₄H₄O₄

Colore e forma: Powder

Peso molecolare: 343.17029

Ref: 45-1134506

Clemastine fumarate - Bio-X ™

CAS: 14976-57-9

Clemastine is an antihistamine drug that has anticholinergic and sedative effects. It is a selective histamine H1 antagonist and binds to the histamine H1 receptor, blocking the action of endogenous histamine. Clemastine is used in cases of allergy or cold. Also, it has shown to reduce the symptoms of the rhinovirus infection, such as, sneezing and rhinorrhea.

Formula: C₂₁H₂₆ClNO•C₄H₄O₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 459.96 g/mol

Ref: 3D-BC164321

Clemastine fumarate

CAS: 14976-57-9

Histamine (H1) receptor antagonist

Formula: C₂₅H₃₀ClNO₅

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 459.96 g/mol

Ref: 3D-FC20473