CAS 150683-30-0

Tolvaptan

Descrizione:

Tolvaptan è un antagonista selettivo del recettore V2 della vasopressina utilizzato principalmente nel trattamento di condizioni come l'iponatremia e la malattia renale policistica autosomica dominante (ADPKD). È una piccola molecola organica caratterizzata dalla sua capacità di inibire l'azione della vasopressina, un ormone che regola la ritenzione di acqua nei reni. Questa inibizione porta a un aumento della produzione di urina e a un successivo aumento dei livelli di sodio sierico. Tolvaptan viene tipicamente somministrato per via orale ed è noto per la sua relativamente alta biodisponibilità. La sostanza è classificata come un antagonista non peptidico e ha una struttura molecolare specifica che contribuisce alle sue proprietà farmacologiche. Gli effetti collaterali comuni possono includere sete, bocca secca e potenziali anomalie nella funzione epatica, richiedendo un monitoraggio regolare durante il trattamento. A causa del suo meccanismo d'azione, Tolvaptan è particolarmente utile nella gestione delle condizioni di sovraccarico di liquidi, rendendolo un agente terapeutico prezioso in nefrologia ed endocrinologia.

Formula: C₂₆H₂₅ClN₂O₃

InChI: InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)

InChI key: InChIKey=GYHCTFXIZSNGJT-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(=CC(Cl)=CC2)C(O)CCC1)C3=C(C)C=C(NC(=O)C4=C(C)C=CC=C4)C=C3

Sinonimi:

• 1-[4-(2-Methylbenzoylamino)-2-methylbenzoyl]-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-ol
• 1H-1-Benzazepine, benzamide deriv.
• Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-
• Jinarc
• Jynarque
• N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide
• N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide
• N-[4-[(5R)-7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]-3-methylphenyl]-2-methylbenzamide
• N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
• N-{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide
• Opc 41061
• Samsca

Tolvaptan

CAS: 150683-30-0

Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Formula: C₂₆H₂₅ClN₂O₃

Colore e forma: White Powder

Peso molecolare: 448.15537

Ref: 45-1672060

Tolvaptan

CAS: 150683-30-0

Formula: C₂₆H₂₅ClN₂O₃

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 448.94

Ref: 7W-GP7013

Tolvaptan

CAS: 150683-30-0

Formula: C₂₆H₂₅ClN₂O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 448.95

Ref: 4Z-T-691

Tolvaptan

Prodotto controllato

CAS: 150683-30-0

Formula: C₂₆H₂₅ClN₂O₃

Colore e forma: Neat

Peso molecolare: 448.94

Ref: 86-MM3561.00

Tolvaptan

CAS: 150683-30-0

Tolvaptan (OPC-41061) is an orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.

Formula: C₂₆H₂₅ClN₂O₃

Purezza: 99.78% - >99.99%

Colore e forma: Solid

Peso molecolare: 448.94

Ref: TM-T2326

Tolvaptan RS

CAS: 150683-30-0

Colore e forma: White Crystals Or Crystalline Powder

Ref: 2K-1098100021

N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

CAS: 150683-30-0

Purezza: 95.0%

Colore e forma: Solid

Peso molecolare: 448.95001220703125

Ref: 10-F361970

Tolvaptan

Prodotto controllato

CAS: 150683-30-0

Applications Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006);

Formula: C₂₆H₂₅ClN₂O₃

Colore e forma: White To Off-White

Peso molecolare: 448.94

Ref: TR-T536650

Tolvaptan - Bio-X ™

Prodotto controllato

CAS: 150683-30-0

Tolvaptan is a vasopressin receptor antagonist. It binds to the V2 receptor in the cytosol and prevents it from activating the aquaporin 2 channel, which regulates water permeability. Inhibition of vasopressin receptors in the kidneys improves fluid and electrolyte balance. Tolvaptan has been shown to be effective for treating congestive heart failure, as well as other disorders that are associated with fluid retention, such as renal dysfunction and metabolic syndrome. Tolvaptan can also be used in combination therapy with other drugs to treat these conditions.

Formula: C₂₆H₂₅ClN₂O₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 448.94 g/mol

Ref: 3D-BT164486

Tolvaptan

CAS: 150683-30-0

Formula: C₂₆H₂₅ClN₂O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 448.9413

Ref: IN-DA00366Q

Tolvaptan

Prodotto controllato

CAS: 150683-30-0

Tolvaptan is a vasopressin receptor antagonist. It binds to the V2 receptor in the cytosol and prevents it from activating the aquaporin 2 channel, which regulates water permeability. Inhibition of vasopressin receptors in the kidneys improves fluid and electrolyte balance. Tolvaptan has been shown to be effective for treating congestive heart failure, as well as other disorders that are associated with fluid retention, such as renal dysfunction and metabolic syndrome. Tolvaptan can also be used in combination therapy with other drugs to treat these conditions.

Formula: C₂₆H₂₅ClN₂O₃

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 448.94 g/mol

Ref: 3D-FT34175