CAS 151922-16-6

(4S,4aS,5aR,12aS)-4,7-Bis(dimetilamino)-9-[[2-(dimetilamino)acetil]amino]-1,4,4a,5,5a,6,11,12a-octaidro-3,10,12,12a-tetraidrossi-1,11-diosso-2-naftacenecarbossamide

Descrizione:

La sostanza chimica con il nome "(4S,4aS,5aR,12aS)-4,7-Bis(dimetilamino)-9-[[2-(dimetilamino)acetil]amino]-1,4,4a,5,5a,6,11,12a-octaidro-3,10,12,12a-tetraidrossi-1,11-diosso-2-naftacenecarbossamide" e numero CAS "151922-16-6" è un composto organico complesso caratterizzato dalla sua struttura a più anelli e da più gruppi funzionali. Presenta uno scheletro di naftacene, che contribuisce alla sua potenziale attività biologica. La presenza di gruppi dimetilamminici suggerisce che potrebbe mostrare proprietà basiche, influenzando la sua solubilità e interazione con i sistemi biologici. Il composto contiene anche funzionalità idrossiliche e carboniliche, che possono partecipare a legami idrogeno e possono aumentare la sua reattività. La sua stereochimica, indicata dalla configurazione specifica in diversi centri chirali, è cruciale per la sua attività biologica e le proprietà farmacologiche. Questo composto è di interesse nella chimica medicinale, in particolare per le sue potenziali applicazioni nello sviluppo di farmaci, sebbene specifiche attività biologiche e usi terapeutici richiedano ulteriori indagini.

Formula: C₂₇H₃₅N₅O₈

InChI: InChI=1S/C27H35N5O8/c1-30(2)10-16(33)29-14-9-15(31(3)4)12-7-11-8-13-20(32(5)6)23(36)19(26(28)39)25(38)27(13,40)24(37)17(11)22(35)18(12)21(14)34/h9,11,13,20,34,36-37,40H,7-8,10H2,1-6H3,(H2,28,39)(H,29,33)/t11-,13-,20-,27-/m0/s1

InChI key: InChIKey=CTFJMTPWQZXWGH-ISIOAQNYSA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(N(C)C)C=C(NC(CN(C)C)=O)C4O)[H])[H]

Sinonimi:

• (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-9-[[2-(dimethylamino)acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
• 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-(((dimethylamino)acetyl)amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,12aalpha))-
• 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[(dimethylamino)acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
• 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[(dimethylamino)acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, [4S-(4α,4aα,5aα,12aα)]-
• 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[2-(dimethylamino)acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
• 4,7-Bis(dimethylamino)-9-(((dimethylamino)acetyl)amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide (4S-(4alpha,4aalpha,5aalpha,12aalpha))-
• Dmg-mino
• N,N-Dimethylglycylamido-minocycline
• N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5,5a,6,6a,7,8,9,10,10a,11-decahydrotetracen-2-yl]-N~2~,N~2~-dimethylglycinamide

N,N-Dimethylglycylamido-minocycline dihydrochloride

CAS: 151922-16-6

N,N-Dimethylglycylamido-minocycline dihydrochloride is a medicinal compound that is used as an inhibitor of protein kinases in cancer research. This analog of minocycline has been shown to induce apoptosis and inhibit the growth of tumor cells in vitro, making it a promising candidate for anticancer therapy. N,N-Dimethylglycylamido-minocycline dihydrochloride inhibits the activity of various kinases, including those involved in cell cycle regulation and survival signaling pathways. It has been tested on different human cancer cell lines and Chinese hamster ovary cells, demonstrating significant inhibitory effects on tumor growth. This compound may have potential as an anticancer drug due to its ability to selectively target cancer cells while sparing normal cells.

Formula: C₂₇H₃₅N₅O₈

Purezza: Min. 95%

Peso molecolare: 557.6 g/mol

Ref: 3D-BGA92216