CAS 152-11-4

Cloridrato di verapamil

Descrizione:

Cloridrato di verapamil è un bloccante dei canali del calcio utilizzato principalmente nel trattamento dell'ipertensione, dell'angina pectoris e di alcuni tipi di aritmie. È una polvere cristallina bianca o bianco sporco solubile in acqua e alcol, rendendolo adatto per varie formulazioni farmaceutiche. Il composto agisce inibendo l'afflusso di ioni di calcio nelle cellule muscolari cardiache e lisce, portando al rilassamento del muscolo liscio vascolare e a una diminuzione della frequenza cardiaca. Questo meccanismo aiuta a ridurre la pressione sanguigna e a diminuire il carico di lavoro del cuore. Cloridrato di verapamil ha una biodisponibilità relativamente bassa a causa di un ampio metabolismo di primo passaggio, e la sua farmacocinetica può essere influenzata da fattori come età, funzione epatica e farmaci concomitanti. Gli effetti collaterali comuni possono includere vertigini, mal di testa e disturbi gastrointestinali. Come con qualsiasi farmaco, è essenziale utilizzare Cloridrato di verapamil sotto supervisione medica per gestire efficacemente le potenziali interazioni e controindicazioni.

Formula: C₂₇H₃₈N₂O₄·ClH

InChI: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H

InChI key: InChIKey=DOQPXTMNIUCOSY-UHFFFAOYSA-N

SMILES: C(CCCN(CCC1=CC(OC)=C(OC)C=C1)C)(C(C)C)(C#N)C2=CC(OC)=C(OC)C=C2.Cl

Sinonimi:

• (+/-)-5-[N-(3,4-dimethoxyphenylethyl)-METHYLAMINO]-2-(3,4-dimethoxyphenyl)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE
• 2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]-2-(propan-2-yl)pentanenitrile hydrochloride
• 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-Dimethoxyphenyl)Ethyl](Methyl)Amino}-2-(Propan-2-Yl)Pentanenitrile Hydrochloride (1:1)
• 5-[(3,4-DIMETHOXYPHENETHYL)METHYLAMINO]-2-(3,4-dimethoxyphenyl)-2-ISOPROPYL-VALERONITRILE HYDROCHLORIDE
• Akilen
• Alpha-(3-((2-(3,4-Dimethoxyphenyl)Ethyl)Methylamino)Propyl)-3,4-Dimethoxy-Alpha-(1-Methylethyl)-
• Alpha-(3-((2-(3,4-Dimethoxyphenyl)Ethyl)Methylamino)Propyl)-3,4-Dimethoxy-Alpha-(1-Methylethyl)-Benzeneacetonitrile Hydrochloride
• Anpec
• Apo-Verap
• Apoacor
• Arapamyl
• Azupamil
• Benzeneacetonitrile Hydrochloride
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, hydrochloride (1:1)
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, monohydrochloride
• Berkatens
• Calan
• Calan SR
• Calaptin
• Calaptin 240SR
• Calaptin 80
• Cardiabeltin
• Cardiagutt
• Cardibeltin
• Caveril
• Civicor
• Civicor Retard
• Coraver
• Cordilox
• Cordilox SR
• Corpamil
• Covera HS
• Dignover
• Dilacoran
• Dilacoran HTA
• Drosteakard
• Finoptin
• Flamon
• Geangin
• Hexasoptin
• Hexasoptin Retard
• Ikacor
• Ikapress
• Iproveratril
• Iproveratril hydrochloride
• Iproveratrilhydrochloride
• Iso-Card SR
• Isoptin
• Isoptin Retard
• Isoptin SR
• Isoptin, hydrochloride
• Isoptine
• Isoptino
• Izoptin hydrochloride
• Izoptinhydrochloride
• Lekoptin Retard
• Lu 20175
• Manidon
• Manidon Retard
• NSC 272366
• NSC 657799
• Novo-Veramil
• Quasar
• Ravamil SR
• Securon
• Univer
• Valeronitrile, 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-, hydrochloride
• Valeronitrile, 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-, monohydrochloride
• Vasolan
• Vasomil
• Vasopten
• Veracaps SR
• Veracim
• Veracor
• Verahexal
• Veraloc
• Veramex
• Veramil
• Verapamil HCl
• Verapin
• Verapress 240SR
• Veraptin
• Verdilac
• Verelan
• Verelan SR
• Verexamil
• Verogalid ER
• Verpal
• Vetrimil
• dl-Verapamil hydrochloride
• (+/-)-Verapamil hydrochloride

Verapamil Hydrochloride

Prodotto controllato

CAS: 152-11-4

Applications A calcium channel blocker. Antihypertensive; antianginal; antiarrhythmic (class IV).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Atlas, D, and Adler, M.: Proc. Natl. Acad. Sci. USA, 78, 1237 (1981), Janis, R., et al.: Adv. Drug. Res., 16, 309 (1987)

Formula: C₂₇H₃₈N₂O₄·ClH

Colore e forma: Neat

Peso molecolare: 491.06

Ref: TR-V125000

Verapamil hydrochloride

CAS: 152-11-4

L-type calcium channel blocker

Formula: C₂₇H₃₉ClN₂O₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 491.06 g/mol

Ref: 3D-FV28686

Verapamil HCl - Bio-X ™

CAS: 152-11-4

Verapamil is drug that belongs to the class of drugs known as calcium channel blockers. It is used to treat high blood pressure, angina and other cardiovascular disorders. It works by relaxing the blood vessels so that blood can flow more easily. It does this by inhibiting the calcium ion influx through slow channels into conductile, contractile myocardial cells and vascular smooth muscle cells.

Formula: C₂₇H₃₈N₂O₄•HCl

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 491.06 g/mol

Ref: 3D-BV164516

Verapamil hydrochloride

CAS: 152-11-4

Formula: C₂₇H₃₉ClN₂O₄

Purezza: 98.0%

Colore e forma: Solid

Peso molecolare: 491.07

Ref: 10-F047206