CAS 152-58-9

11-Desossicortisolo

Descrizione:

11-Desossicortisolo, noto anche come cortodoxone, è un ormone steroideo che svolge un ruolo significativo nella biosintesi dei corticosteroidi. È classificato come un glucocorticoide ed è prodotto nella corteccia surrenale. La struttura chimica di 11-Desossicortisolo presenta uno scheletro steroideo, caratterizzato da quattro anelli di carbonio fusi, con gruppi funzionali specifici che contribuiscono alla sua attività biologica. È un precursore nella sintesi del cortisolo, che è cruciale per regolare il metabolismo, la risposta immunitaria e la risposta allo stress nel corpo. Il numero CAS 152-58-9 identifica in modo univoco questo composto nei database chimici. In termini di solubilità, 11-Desossicortisolo è generalmente lipofilo, consentendogli di attraversare facilmente le membrane cellulari ed esercitare i suoi effetti sui tessuti bersaglio. La sua attività biologica è mediata attraverso il legame ai recettori dei glucocorticoidi, influenzando l'espressione genica e le funzioni cellulari. A causa del suo ruolo nel sistema endocrino, le alterazioni nei livelli di 11-Desossicortisolo possono essere indicative di varie condizioni di salute, inclusa l'insufficienza surrenalica o l'iperplasia.

Formula: C₂₁H₃₀O₄

InChI: InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1

InChI key: InChIKey=WHBHBVVOGNECLV-OBQKJFGGSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]

Sinonimi:

• (8R,10R,13S,17R)-17-Hydroxy-17-(2-hydroxy-acetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
• (8Xi,9Xi,10Xi,13Xi,14Xi)-17,21-Dihydroxypregn-4-Ene-3,20-Dione
• 11-Deoxy-17-hydrocorticosterone
• 11-Deoxy-17-hydroxycorticosterone
• 11-Deoxycortisol
• 11-Deoxycortisone
• 11-Deoxyhydrocortisone
• 11-Desoxy-17-hydroxycorticosterone
• 11-Desoxy-17α-hydroxycorticosterone
• 11-Desoxycortisol
• 11-Desoxycortisone
• 11-Desoxyhydrocortisone
• 11-Dioxycortisol
• 17,21-Dihydroxy-4-pregnene-3,20-dione
• 17,21-Dihydroxy-Pregn-4-Ene-3,20-Dione
• 17,21-Dihydroxypregn-4-en-3,20-dione
• 17,21-Dihydroxypregn-4-ene-3,20-dione
• 17,21-Dihydroxyprogesterone
• 17-Hydroxy-11-deoxycorticosterone
• 17alpha,21-Dihydroxypregn-4-ene-3,20-dione
• 17Α,21-Dihydroxypregn-4-Ene-3,20-Dione
• 17α,21-Dihydroxy-4-pregnen-3,20-dion
• 17α,21-Dihydroxy-4-pregnen-3,20-dione
• 17α,21-Dihydroxyprogesterone
• 17α-Hydroxycortexone
• 4-Pregnen-17α,21-diol-3,20-dion
• 4-Pregnen-17α,21-diol-3,20-dione
• 4-Pregnene-11β,17,21-triol-3,20-dione
• 4-Pregnene-17α, 21-diol-3,20-dione
• Compound S
• Corticosterone, 11-deoxy-17-hydroxy-
• Cortifen
• Cortisol, 11-deoxy-
• Cortisol, 11-dioxy-
• Cortodoxon
• Cortodoxona
• Cortodoxone
• Nsc 18317
• Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
• Reichstein S
• Reichstein substance S
• Reichstein's Substanz S
• Reichstein's compound S
• Reichstein's substance S
• Sk&F 3050
• Skf 3050
• Substance S
• cortodoxone (INN)
• Δ4-Pregnene-17α,21-diol-3,20-dione
• Δ⁴-Pregnene-17α,21-diol-3,20-dione

Cortexolone

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow to Light orange powder to crystal

Peso molecolare: 346.47

Ref: 3B-C1478

11-Deoxycortisol (17,21-Dihydroxypregn-4-ene-3,20-dione) 1.0 mg/ml in Methanol

CAS: 152-58-9

Colore e forma: Single Solution

Ref: 61-AMP0185.08-01

11-Deoxycortisol, 1mg/ml in Acetonitrile

CAS: 152-58-9

Colore e forma: Single Solution

Ref: LP-COR-1627-1LA

Cortodoxone (17,21-Dihydroxypregn-4-ene-3,20-dione)

CAS: 152-58-9

Adrenal cortical hormones and their derivatives nesoi

Formula: C₂₁H₃₀O₄

Colore e forma: White Powder

Peso molecolare: 346.21441

Ref: 45-1A11650

Cortodoxone

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 346.4605

Ref: IN-DA003P2I

Cortexolone (Hydrocortisone EP Impurity F)

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Peso molecolare: 346.47

Ref: 4Z-C-502001

Cortexolone

CAS: 152-58-9

Cortexolone

Purezza: 98%

Peso molecolare: 346.47g/mol

Ref: 54-OR1029721

Cortodoxone

CAS: 152-58-9

Cortodoxone

Purezza: ≥98%

Peso molecolare: 346.46g/mol

Ref: 54-BUP00016

Reichsteins substance S

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 346.46

Ref: 7W-GK2007

17,21-Dihydroxypregn-4-ene-3,20-dione (Reichstein's Substance S)

Prodotto controllato

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Colore e forma: Neat

Peso molecolare: 346.46

Ref: 86-MM0185.08

11-Deoxycortisol

CAS: 152-58-9

Colore e forma: Neat

Ref: LP-COR-1627-10

Cortodoxone

CAS: 152-58-9

Cortodoxone (11-Desoxycortisol) is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.

Formula: C₂₁H₃₀O₄

Purezza: 99.26% - 99.87%

Colore e forma: Solid

Peso molecolare: 346.46

Ref: TM-T2748

Cortexolone-d5 (Hydrocortisone EP Impurity F-d5)

CAS: 152-58-9

Formula: C₂₁H₂₅D₅O₄

Peso molecolare: 351.50

Ref: 4Z-C-502002

Hydrocortisone EP Impurity F

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Peso molecolare: 346.47

Ref: ST-EA-CP-H9006

11-Deoxy Cortisol-d7

Prodotto controllato

CAS: 152-58-9

Applications Glucocorticoid receptor binding.A representative lots showed approximately 10% d8.
References Gazdar, A., et al.: Cancer Res., 50, 5488, (1990), Bird, I., et al.: Endocrinology, 134, 2468 (1994), Auchus, R., et al.: J. Biol. Chem., 273, 3158 (1998), Dardis, A., et al.: J. Endocrinol., 179, 131 (2003),

Formula: C₂₁H₂₃D₇O₄

Colore e forma: Neat

Peso molecolare: 353.5

Ref: TR-D232602

11-Deoxy Cortisol

CAS: 152-58-9

Impurity Hydrocortisone EP Impurity F
Applications 11-Deoxy Cortisol (Hydrocortisone EP Impurity F) is a glucocorticoid receptor binding.
References Gazdar, A., et al.: Cancer Res., 50, 5488, (1990), Bird, I., et al.: Endocrinology, 134, 2468 (1994), Auchus, R., et al.: J. Biol. Chem., 273, 3158(1998), Dardis, A., et al.: J. Endocrinol., 179, 131 (2003),

Formula: C₂₁H₃₀O₄

Colore e forma: Neat

Peso molecolare: 346.46

Ref: TR-D232600

17,21-Dihydroxy-pregn-4-ene-3,20-dione

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 346.467

Ref: 10-F242196

11-Deoxy-17-hydroxycorticosterone

Prodotto controllato

CAS: 152-58-9

11-Deoxycorticosterone (11DOC) is a naturally occurring corticosteroid that has been studied as a potential treatment for cancer. 11DOC is an antagonist of the mineralocorticoid receptor, which regulates sodium and potassium ions in the body. It also inhibits lymphocyte transformation and cell nuclei. The 11DOC-induced tumor regression was found to be due to decreased cortisol concentrations and increased corticosterone concentration in the experimental model. Increased corticosterone concentration led to cell lysis, while decreased cortisol concentration inhibited inflammatory lesion growth. Structural analysis revealed that 11DOC binds to the mineralocorticoid receptor with high affinity, but does not bind with high affinity to the glucocorticoid receptor. This suggests that 11DOC may be used for tumor treatment without negative side effects such as hair loss or increased appetite.

Formula: C₂₁H₃₀O₄

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 346.46 g/mol

Ref: 3D-FD21045

11-Deoxycortisol (17,21-Dihydroxypregn-4-ene-3,20-dione)

CAS: 152-58-9

Colore e forma: Neat

Ref: 61-FOR0185.08