CAS 15291-75-5

Ginkgolide A

Descrizione:

Ginkgolide A è un composto naturale derivato dalle foglie dell'albero Ginkgo biloba, noto per i suoi potenziali benefici per la salute e proprietà medicinali. Appartiene a una classe di composti chiamati terpenoidi, specificamente un tipo di lattone diterpenico. Ginkgolide A è caratterizzato dalla sua unica struttura biciclica, che contribuisce alla sua attività biologica. Mostra vari effetti farmacologici, comprese proprietà neuroprotettive, anti-infiammatorie e antiossidanti, rendendolo di interesse nello studio delle malattie neurodegenerative e del miglioramento cognitivo. Inoltre, Ginkgolide A è stato studiato per la sua capacità di inibire il fattore attivante delle piastrine (PAF), che gioca un ruolo nell'infiammazione e nella trombosi. Il composto si trova tipicamente in integratori erboristici ed estratti derivati dal Ginkgo biloba, e il suo profilo di sicurezza è stato valutato in vari studi. Tuttavia, come molti prodotti erboristici, può interagire con altri farmaci, quindi si consiglia cautela quando usato in concomitanza con anticoagulanti o farmaci antipiastrinici. In generale, Ginkgolide A rappresenta un'area significativa di ricerca in fitochimica e farmacologia.

Formula: C₂₀H₂₄O₉

InChI: InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18?,19-,20?/m1/s1

InChI key: InChIKey=FPUXKXIZEIDQKW-IKIFPUOBSA-N

SMILES: O[C@@]12C34[C@]5(C6([C@](O3)(OC(=O)[C@@H]6O)[H])[C@H](C(C)(C)C)C[C@]5(OC4=O)[H])C[C@@]1(OC(=O)[C@H]2C)[H]

Sinonimi:

• (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
• (1R,3aR,4bR,5S,7aS,9R,11S)-11-tert-butyl-1,4b-dihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
• (3aR,4aR,4bR,5S,7aS,9R,11S)-11-tert-butyl-1,4b-dihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R-(1alpha,3beta,3aS*,4beta,6aalpha,7aalpha,7balpha,8alpha,10aalpha,11 aS*))-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-4,7b-dihydroxy-8-methyl-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11aS*)]-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-4,7b-dihydroxy-8-methyl-
• Bilobalide A
• Bn 52020
• [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11aS*)]-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione

Ginkgolide A

CAS: 15291-75-5

Formula: C₂₀H₂₄O₉

Purezza: >98.0%(HPLC)(qNMR)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 408.40

Ref: 3B-G0521

Ginkgolide A

CAS: 15291-75-5

Platelet-Activating Factor (PAF) antagonist

Formula: C₂₀H₂₄O₉

Peso molecolare: 408.41

Ref: 02-J62384

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₂₀H₂₄O₉

Purezza: (HPLC) ≥98%

Colore e forma: Powder

Peso molecolare: 408.41

Ref: 11-3728S

Ginkgolide A

CAS: 15291-75-5

Formula: C₂₀H₂₄O₉

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 408.3992

Ref: IN-DA003839

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A

Purezza: 97%

Peso molecolare: 408.4g/mol

Ref: 54-OR1024130

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A

Purezza: ≥98%

Peso molecolare: 408.4g/mol

Ref: 54-BUP06903

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A is a platelet-activating factor antagonist, it can inhibit the neurotoxicity of prions or amyloid-beta1-42, may be relevant treatments for prion or Alzheimer's diseases.Ginkgolide A has neuroprotective, and anxiolytic-like effects, it is widely used for the treatment of cardiovascular diseases and diabetic vascular complications, which might be achieved through regulating the STAT3-mediated pathway.

Formula: C₂₀H₂₄O₉

Purezza: 95%~99%

Peso molecolare: 408.403

Ref: BP-BP0646

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A (BN-52020), from Ginkgo biloba leaves, is an active PAF antagonist with potential in treating inflammation and immune disorders.

Formula: C₂₀H₂₄O₉

Purezza: 98.76% - 99.81%

Colore e forma: White Powder

Peso molecolare: 408.4

Ref: TM-T2749

Ginkgolide A

CAS: 15291-75-5

Formula: C₂₀H₂₄O₉

Peso molecolare: 408.40

Ref: 4Z-G-176003

Ginkgolide A

CAS: 15291-75-5

Formula: C₂₀H₂₄O₉

Purezza: (HPLC) ≥ 98.0%

Colore e forma: Off-white powder

Peso molecolare: 408.41

Ref: 7W-GP9109

Ginkgolide a

CAS: 15291-75-5

Lactone

Formula: C₂₀H₂₄O₉

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 408.41

Ref: 5G-89204

Ginkgolide A

Prodotto controllato

CAS: 15291-75-5

Applications Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.
References Korth, R., et al.: Eur. J. Pharmacol., 152, 101 (1988), Braquet, P., et al.: Med. Res. Rev., 11, 295 (1991), van Beek, T.A., et al.: Bioorg. Med. Chem., 13, 5001 (2005)

Formula: C₂₀H₂₄O₉

Colore e forma: Neat

Peso molecolare: 408.40

Ref: TR-G387425

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A is a terpenoid lactone, which is a diterpene known for its presence in the leaves of the Ginkgo biloba tree. As a bioactive compound, it is naturally sourced from this ancient plant, which has been utilized in traditional medicine for centuries. Ginkgolide A acts primarily as an antagonist of platelet-activating factor (PAF), thereby influencing a range of physiological processes. Its modulatory effects on neurotransmission and vascular function arise from its ability to inhibit PAF binding to its receptor, reducing platelet aggregation and improving microcirculatory flow.

Formula: C₂₀H₂₄O₉

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 408.4 g/mol

Ref: 3D-FG10335

Ginkgolide Impurity A

CAS: 15291-75-5

Formula: C₂₀H₂₄O₉

Peso molecolare: 408.40

Ref: ST-EA-CP-G15001