CAS 15291-76-6

Ginkgolide C

Descrizione:

Ginkgolide C è un composto naturale classificato come un lattone diterpenica, derivato principalmente dalle foglie dell'albero Ginkgo biloba. È uno dei diversi ginkgolidi, unici per questa specie e che contribuiscono alle sue proprietà medicinali. Ginkgolide C è noto per i suoi potenziali effetti neuroprotettivi ed è spesso studiato per il suo ruolo nel migliorare la funzione cognitiva e la circolazione sanguigna. Il composto presenta proprietà antiossidanti, che possono aiutare a mitigare lo stress ossidativo nelle cellule. Inoltre, Ginkgolide C è stato studiato per la sua capacità di inibire il fattore attivante delle piastrine (PAF), suggerendo potenziali applicazioni terapeutiche nella salute cardiovascolare. In termini di caratteristiche fisiche, Ginkgolide C è tipicamente un solido cristallino di colore giallo pallido a bianco, ed è solubile in solventi organici ma ha una solubilità limitata in acqua. La sua struttura molecolare include più anelli e gruppi funzionali che contribuiscono alla sua attività biologica. In generale, Ginkgolide C è un composto significativo nella medicina erboristica e nella farmacologia, con ricerche in corso sui suoi vari benefici per la salute.

Formula: C₂₀H₂₄O₁₁

InChI: InChI=1/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3/t5-,6-,7+,8?,9?,10-,11+,15+,17?,18?,19-,20+/m1/s1

InChI key: InChIKey=AMOGMTLMADGEOQ-XQMLRWPUSA-N

SMILES: OC1[C@@]23[C@@]45[C@](O[C@]2([C@]6(O)[C@]1(OC(=O)[C@H]6C)[H])C(=O)O[C@@]3([C@H](O)[C@@H]4C(C)(C)C)[H])(OC(=O)[C@@H]5O)[H]

Sinonimi:

• (1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
• (1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
• (3aR,4aR,4bR,5S,7aS,9S,10R,11S)-11-tert-butyl-1,4b,8,10-tetrahydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
• 1,7-Dihydroxy-Ginkgolide A
• 11-tert-butyl-1,4b,8,10-tetrahydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
• 5H-Dicyclopenta[b,c]furan-3,5a(6H)-diacetic acid, 6-tert-butyl-3a-carboxyhexahydro-α^5a,1,2,3,5,7,8-heptahydroxy-α³-methyl-, tri-γ-lactone
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-, (1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-, [1R-(1α,2α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11α,11aR*)]-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-2,4,7b,11-tetrahydroxy-8-methyl-
• Bn 52022
• Bn52022
• Gingkolide C
• Ginkgolide A, 1,7-dihydroxy-, (1β,7β)-
• GinkgolideA,1,7-dihydroxy-, (1α,7β)-
• 5H-Dicyclopenta[b,c]furan-3,5a(6H)-diacetic acid, 6-tert-butyl-3a-carboxyhexahydro-α5a,1,2,3,5,7,8-heptahydroxy-α3-methyl-, tri-γ-lactone
• CGinkgolid
• Ginkgolide C,1,7-Dihydroxy-ginkgolide A

Ginkgolide C

CAS: 15291-76-6

Ginkgolide C analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₂₀H₂₄O₁₁

Purezza: (HPLC) ≥98%

Colore e forma: Powder

Peso molecolare: 440.41

Ref: 11-3730S

Ginkgolide C

CAS: 15291-76-6

Formula: C₂₀H₂₄O₁₁

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 440.3980

Ref: IN-DA00AOJI

Ginkgolide C

CAS: 15291-76-6

Ginkgolide C

Purezza: 97%

Peso molecolare: 440.4g/mol

Ref: 54-OR1024157

Ginkgolide C

CAS: 15291-76-6

Ginkgolide C

Purezza: ≥98%

Peso molecolare: 440.4g/mol

Ref: 54-BUP00111

Ginkgolide C

CAS: 15291-76-6

Ginkgolide C is a potent inhibitor of collagen-stimulated platelet aggregation, it may increase intracellular cAMP and cGMP production and MMP-9 activity, inhibit intracellular Ca(2+) mobilization and TXA(2) production. Ginkgolide C has anti-adipogenic and ameliorating Alzheimer disease effects; it also can increase△LVP significantly,enhances the myocardial systolic and diastolic function of rats,but has no significant effect on HR while it shows inotropic activity.

Formula: C₂₀H₂₄O₁₁

Purezza: 95%~99%

Peso molecolare: 440.401

Ref: BP-BP0648

Ginkgolide C

CAS: 15291-76-6

Formula: C₂₀H₂₄O₁₁

Peso molecolare: 440.40

Ref: 4Z-G-176005

Ginkgolide C

CAS: 15291-76-6

Formula: C₂₀H₂₄O₁₁

Peso molecolare: 440.40

Ref: 7W-GP0779

Ginkgolide C

CAS: 15291-76-6

Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.

Formula: C₂₀H₂₄O₁₁

Purezza: 99.71% - 99.98%

Colore e forma: White Powder

Peso molecolare: 440.40

Ref: TM-T2750

Ginkgolide c

CAS: 15291-76-6

Lactone

Formula: C₂₀H₂₄O₁₁

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 440.4

Ref: 5G-89206

Ginkgolide C

Prodotto controllato

CAS: 15291-76-6

Applications Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.
References Korth, R., et al.: Eur. J. Pharmacol., 152, 101 (1988), Braquet, P., et al.: Med. Res. Rev., 11, 295 (1991), van Beek, T.A., et al.: Bioorg. Med. Chem., 13, 5001 (2005)

Formula: C₂₀H₂₄O₁₁

Purezza: >90%

Colore e forma: Neat

Peso molecolare: 440.40

Ref: TR-G387435

Ginkgolide C

CAS: 15291-76-6

Ginkgolide C is a terpenoid lactone, which is a natural compound isolated from the leaves of the Ginkgo biloba tree. Ginkgolide C is primarily known for its activity as a specific antagonist of platelet-activating factor (PAF), a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation. Its mode of action involves the inhibition of PAF binding to its receptor, thereby reducing PAF-related inflammatory responses and platelet aggregation.

Formula: C₂₀H₂₄O₁₁

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 440.4 g/mol

Ref: 3D-FG23662

Ginkgolide Impurity C

CAS: 15291-76-6

Formula: C₂₀H₂₄O₁₁

Peso molecolare: 440.40

Ref: ST-EA-CP-G15003