CAS 153-61-7

Cefalotina

Descrizione:

Cefalotina è un antibiotico semisintetico appartenente alla classe delle cefalosporine, utilizzato principalmente per le sue proprietà antibatteriche. È efficace contro una gamma di batteri Gram-positivi e alcuni Gram-negativi, rendendolo utile nel trattamento di varie infezioni. Il composto è caratterizzato dalla sua struttura beta-lattamica, che è essenziale per il suo meccanismo d'azione, poiché inibisce la sintesi della parete cellulare batterica. Cefalotina è tipicamente somministrato per iniezione ed è noto per la sua stabilità contro alcune beta-lattamasi, anche se non è resistente a tutti i tipi. La sua farmacocinetica implica un rapido assorbimento e distribuzione nel corpo, con una emivita relativamente breve, necessitando di dosi multiple per un trattamento efficace. Gli effetti collaterali comuni possono includere reazioni allergiche, disturbi gastrointestinali e potenziali impatti sulla funzione renale. Come con altri antibiotici, l'emergere di resistenza è una preoccupazione, evidenziando l'importanza di un uso appropriato in contesti clinici. Nel complesso, Cefalotina rimane un'opzione preziosa nell'arsenale degli antibiotici, particolarmente per le infezioni causate da organismi suscettibili.

Formula: C₁₆H₁₆N₂O₆S₂

InChI: InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1

InChI key: InChIKey=XIURVHNZVLADCM-IUODEOHRSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CC3=CC=CS3)=O)C2=O)(SCC1COC(C)=O)[H]

Sinonimi:

• (6R,7R)-3-(Acetoxymethyl)-8-Oxo-7-(2-(Thiophen-2-Yl)Acetamido)-5-Thia-1-Aza-Bicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
• (6R,7R)-3-[(Acetyloxy)methyl]-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R-trans)-3-[(Acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6S,7S)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 3-(Acetoxymethyl)-8-oxo-7-[2-(2-thienyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid
• 5-Thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[2-(2-thienyl)acetamido]-, acetate (ester)
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, (6R-trans)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-, (6R,7R)-
• 7-(2-Thienylacetamido)cephalosporanic acid
• 7-(Thiophene-2-acetamido)cephalosporin
• 7-[2-(2-Thienyl)acetylamido]cephalosporanic acid
• CT
• Cefalothin
• Cefalothin Acid
• Cefalotin
• Cefalotin Acid
• Cefalotina
• Cefalotine
• Cephalotin
• Cephalotin acid
• Ceratinine, standard solution
• Fatty acids, tall-oil, sulfonated

Cephalothin

CAS: 153-61-7

Formula: C₁₆H₁₆N₂O₆S₂

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Orange to Green powder to crystal

Peso molecolare: 396.43

Ref: 3B-C2769

Cephalothin (acid), 97%

CAS: 153-61-7

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Formula: C₁₆H₁₅N₂NaO₆S₂

Purezza: 97%

Colore e forma: Powder, White to pale cream

Peso molecolare: 418.41

Ref: 02-H36175

(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 153-61-7

Formula: C₁₆H₁₆N₂O₆S₂

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 396.4380

Ref: IN-DA007HPY

Cephalothin

CAS: 153-61-7

Cephalothin

Purezza: ≥98%

Peso molecolare: 396.44g/mol

Ref: 54-BUP13813

Cefalotin

CAS: 153-61-7

Cefalotin

Purezza: 97%

Peso molecolare: 396.44g/mol

Ref: 54-OR1030085

Cefalotin

CAS: 153-61-7

Formula: C₁₆H₁₆N₂O₆S₂

Purezza: ≥ 97.0%

Colore e forma: White to off-white powder

Peso molecolare: 396.44

Ref: 7W-GA3485

Cefalotin

Prodotto controllato

CAS: 153-61-7

Formula: C₁₆H₁₆N₂O₆S₂

Colore e forma: Neat

Peso molecolare: 396.44

Ref: 04-C11064065

Cefalonium Impurity A (Cefalotin)

CAS: 153-61-7

Formula: C₁₆H₁₆N₂O₆S₂

Peso molecolare: 396.44

Ref: 4Z-C-229002

Cephalothin

CAS: 153-61-7

Cephalothin is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC (Ki: 0.32 μM).

Formula: C₁₆H₁₆N₂O₆S₂

Purezza: 99.62%

Colore e forma: Solid Solid

Peso molecolare: 396.44

Ref: TM-T5570

Cephalothin

Prodotto controllato

CAS: 153-61-7

Applications A first generation cephalosporin antibiotic with a wide range antibacterial activity. It is effective against gram-positive and gram-negative bacteria, and has been tested in respiratory disease and neuromuscular junction studies.
References Shibata, K., et al.: J. Antibiot., 50, 135 (1997); Farra, A., et al.: Int. J. Antimicrob. Agents., 31, 427 (2008); Pichardo, C., et al.: Eur. J. Clin. Microbiol. Infect. Dis., 30, 289 (2011);

Formula: C₁₆H₁₆N₂O₆S₂

Colore e forma: Neat

Peso molecolare: 396.44

Ref: TR-C261150

(6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 153-61-7

Formula: C₁₆H₁₆N₂O₆S₂

Purezza: 97%

Colore e forma: White powder

Peso molecolare: 396.43

Ref: 10-F079464

(6R,7R)-3-((4-Carbamoylpyridin-1-ium-1-yl)methyl)-7-((R)-2-hydroxy-2-(thiophen-2-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Prodotto controllato

CAS: 153-61-7

Formula: C₂₀H₁₈N₄O₆S₂

Colore e forma: Neat

Peso molecolare: 474.51

Ref: TR-C261180

(6R,7R)-3-((4-Carbamoylpyridin-1-ium-1-yl)methyl)-7-((S)-2-hydroxy-2-(thiophen-2-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Prodotto controllato

CAS: 153-61-7

Formula: C₂₀H₁₈N₄O₆S₂

Colore e forma: Neat

Peso molecolare: 474.51

Ref: TR-C261170

(6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 153-61-7

(6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is an antimicrobial agent that inhibits bacterial growth by binding to the penicillin binding protein (PBP), which prevents the synthesis of peptidoglycan. This drug has shown effectiveness against gram positive bacteria, including aerobacter aerogenes, as well as infectious diseases in wastewater treatment plants. It has also been demonstrated to be effective in experimental models of infection due to high resistance and cell signaling pathways. The reaction solution was analyzed by plasma mass spectrometry.

Formula: C₁₆H₁₆N₂O₆S₂

Purezza: Min. 98%

Colore e forma: White Powder

Peso molecolare: 396.44 g/mol

Ref: 3D-FA32097