CAS 153415-45-3

Taxol C

Descrizione:

Taxol C, noto anche con il suo nome chimico come un derivato del paclitaxel, è un prodotto naturale complesso derivato principalmente dalla corteccia dell'albero di tasso del Pacifico (Taxus brevifolia). È classificato come un agente antineoplastico, comunemente usato nella terapia del cancro, in particolare per i tumori ovarici e mammari. Il composto presenta un meccanismo d'azione unico stabilizzando i microtubuli e prevenendo la loro depolimerizzazione, il che interrompe la divisione cellulare normale e porta all'apoptosi nelle cellule tumorali a rapida divisione. Taxol C ha una struttura molecolare specifica caratterizzata da un nucleo di taxano, che include un sistema ad anello biciclico e vari gruppi funzionali che contribuiscono alla sua attività biologica. La sua solubilità è limitata in acqua, rendendo necessario l'uso di solventi o formulazioni per applicazioni terapeutiche. Inoltre, Taxol C è stato studiato per il suo potenziale nel superare la resistenza ai farmaci nei trattamenti oncologici. Come molti agenti chemioterapici, può avere effetti collaterali, tra cui immunosoppressione e neuropatia, il che richiede un attento monitoraggio durante il trattamento.

Formula: C₄₆H₅₇NO₁₄

InChI: InChI=1S/C46H57NO14/c1-8-9-12-21-33(51)47-35(28-17-13-10-14-18-28)36(52)42(55)59-30-23-46(56)40(60-41(54)29-19-15-11-16-20-29)38-44(7,31(50)22-32-45(38,24-57-32)61-27(4)49)39(53)37(58-26(3)48)34(25(30)2)43(46,5)6/h10-11,13-20,30-32,35-38,40,50,52,56H,8-9,12,21-24H2,1-7H3,(H,47,51)/t30-,31-,32+,35-,36+,37+,38-,40-,44+,45-,46+/m0/s1

InChI key: InChIKey=BEHTXUBGUDGCNQ-IEAAAIHOSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(CCCCC)=O)C6=CC=CC=C6)O)=O)C5)[H]

Sinonimi:

• (-)-Taxuyunnanine
• (2alpha,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-13-{[(2R,3S)-3-(hexanoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• Benzenepropanoic acid, α-hydroxy-β-[(1-oxohexyl)amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, α-hydroxy-β-[(1-oxohexyl)amino]-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Paclitaxel C
• Taxuyunnanine A
• benzenepropanoic acid, alpha-hydroxy-beta-[(1-oxohexyl)amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (alphaR,betaS)-
• Taxol C

PACLITAXEL IMPURITY C CRS

CAS: 153415-45-3

PACLITAXEL IMPURITY C CRS

Formula: C₄₆H₅₇NO₁₄

Peso molecolare: 847.9431

Ref: 41-Y0000699

Paclitaxel EP Impurity C

CAS: 153415-45-3

Formula: C₄₆H₅₇NO₁₄

Colore e forma: White To Off-White Solid

Peso molecolare: 847.96

Ref: 4Z-P-2816

Taxol C

CAS: 153415-45-3

Taxol C

Purezza: ≥98%

Peso molecolare: 847.94g/mol

Ref: 54-BUP00746

Taxol C

CAS: 153415-45-3

Formula: C₄₆H₅₇NO₁₄

Purezza: 95%~99%

Peso molecolare: 847.955

Ref: BP-SBP04368

Taxol C

CAS: 153415-45-3

Taxol C can reduce interaction with the P-glycoprotein transporter that may allow for increased permeation of taxanes into the brain.

Formula: C₄₆H₅₇NO₁₄

Purezza: 99.18%

Colore e forma: Solid

Peso molecolare: 847.94

Ref: TM-TN5118

Paclitaxel C

Prodotto controllato

CAS: 153415-45-3

Formula: C₄₆H₅₇NO₁₄

Colore e forma: Neat

Peso molecolare: 847.94

Ref: TR-P132510

N-Debenzoyl-N-hexanoylpaclitaxel

CAS: 153415-45-3

N-Debenzoyl-N-hexanoylpaclitaxel (DHBPTx) is an analog of paclitaxel. It inhibits cell proliferation by binding to the diketone group at the C-10 position of baccatin III, which inhibits the synthesis of taxol and other natural products with a diketone group at this position. DHBPTx is effective against colorectal carcinoma cells in culture, but has not been tested in vivo. This drug has also been shown to be effective against breast cancer cells that express high levels of 10-deacetylase activity. It is metabolized into 10-deacetylbaccatin III, which binds to cellular protein kinase C and causes inhibition of mitosis and apoptosis. In addition, DHBPTx can be conjugated with other drugs such as doxorubicin or vincristine to increase their effectiveness.

Formula: C₄₆H₅₇NO₁₄

Purezza: Min. 95%

Peso molecolare: 847.94 g/mol

Ref: 3D-ID26723

Paclitaxel EP Impurity C

CAS: 153415-45-3

Formula: C₄₆H₅₇NO₁₄

Peso molecolare: 847.95

Ref: ST-EA-CP-P36001