CAS 154-21-2

Lincomicina

Descrizione:

Lincomicina è un antibiotico che appartiene alla classe delle lincosamidi, utilizzato principalmente per trattare infezioni batteriche, in particolare quelle causate da batteri anaerobi e alcuni organismi gram-positivi. È derivato dal batterio *Streptomyces lincolnensis*. Lincomicina è caratterizzato dalla sua capacità di inibire la sintesi proteica batterica legandosi alla subunità ribosomiale 50S, impedendo così la crescita e la riproduzione dei batteri. La sostanza viene tipicamente somministrata per iniezione o per via orale, a seconda della gravità dell'infezione. Lincomicina è noto per la sua efficacia contro infezioni come osteomielite, polmonite e infezioni cutanee. Tuttavia, può causare effetti collaterali, tra cui disturbi gastrointestinali e, in rari casi, reazioni allergiche gravi. La resistenza a Lincomicina può verificarsi, richiedendo una considerazione attenta del suo utilizzo in contesti clinici. La sua struttura chimica include un tioetere e un componente amminoacidico, contribuendo alla sua attività biologica. Come per tutti gli antibiotici, un uso appropriato è cruciale per minimizzare lo sviluppo di resistenza e garantire l'efficacia terapeutica.

Formula: C₁₈H₃₄N₂O₆S

InChI: InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1

InChI key: InChIKey=OJMMVQQUTAEWLP-KIDUDLJLSA-N

SMILES: [C@@H](NC(=O)[C@@H]1C[C@@H](CCC)CN1C)([C@@H](C)O)[C@]2(O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[H]

Sinonimi:

• <span class="text-smallcaps">D</smallcap>-erythro-<smallcap>D</smallcap>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-<smallcap>L</span>-2-pyrrolidinecarboxamido)-1-thio-, trans-α-
• <span class="text-smallcaps">D</smallcap>-erythro-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)-
• <span class="text-smallcaps">D</smallcap>-erythro-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-
• Cillimycin
• D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, trans-α-
• D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)-
• D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amin o]-1-thio-
• Jiemycin
• Lincolcina
• Lincolnensin
• Lincomicina
• Lincomix
• Lincomycin
• Lincomycin A
• Lincomycine
• Medoglycine
• Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-<span class="text-smallcaps">D</smallcap>-erythro-α-<smallcap>D</span>-galacto-octopyranoside
• Nsc 70731
• U 10,149A
• U 10149
• Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside

Lincomycin Hydrochloride Monohydrate

CAS: 154-21-2, 7179-49-9, 859-18-7

Formula: C₁₈H₃₄N₂O₆S·HCl·H₂O

Purezza: >98.0%(T)(qNMR)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 461.02

Ref: 3B-L0166

Lincomycin

CAS: 154-21-2

Formula: C₁₈H₃₄N₂O₆S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 406.5374

Ref: IN-DA00395H

Lincomycin-13C-d3 (Clindamycin Phosphate EP Impurity A-13C-d3)

CAS: 154-21-2

Formula: C₁₇₁₃CH₃₁D₃N₂O₆S

Peso molecolare: 410.55

Ref: 4Z-L-093012

Lincomycin

CAS: 154-21-2

Lincomycin

Purezza: ≥98%

Peso molecolare: 406.54g/mol

Ref: 54-BUP21071

Lincomycin

CAS: 154-21-2

Ref: 7W-GA8072

Lincomycin

CAS: 154-21-2

Lincomycin (U-10149) is a antibiotic against most susceptible gram-positive and cell wall-less bacteria .

Formula: C₁₈H₃₄N₂O₆S

Purezza: 99.77%

Colore e forma: Amorphous Solid Solid

Peso molecolare: 406.54

Ref: TM-T1235L

Lincomycin

CAS: 154-21-2

Impurity Clindamycin Phosphate EP Impurity A
Stability Hygroscopic
Applications Lincomycin (Clindamycin Phosphate EP Impurity A) is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.This compound is a contaminant of emerging concern (CECs).
References Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962), Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964), Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994),

Formula: C₁₈H₃₄N₂O₆S

Colore e forma: White To Off-White

Peso molecolare: 406.54

Ref: TR-L466230

Lincomycin-D3

Prodotto controllato

CAS: 154-21-2

Stability Hygroscopic
Applications Labelled Lincomycin. An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
References Mason, D. J., et al.: Antimicrob. Agents Chemother., 555 (1962), Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964), Muti, H. Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994)

Formula: C₁₈H₃₁D₃N₂O₆S

Colore e forma: White To Yellow

Peso molecolare: 409.56

Ref: TR-L466202

Lincomycin

CAS: 154-21-2

Inhibitor of protein synthesis; lincosamide

Formula: C₁₈H₃₄N₂O₆S

Purezza: Min. 97 Area-%

Colore e forma: White Off-White Powder

Peso molecolare: 406.54 g/mol

Ref: 3D-AL76787

Lincomycin

CAS: 154-21-2

Purezza: 98%

Peso molecolare: 406.5400085

Ref: 10-F608586

Lincomycin-13C,D3

Prodotto controllato

CAS: 154-21-2

Formula: C₁₇CH₃₁D₃N₂O₆S

Colore e forma: Neat

Peso molecolare: 410.55

Ref: TR-L466232

Clindamycin Phosphate EP Impurity A

CAS: 154-21-2

Formula: C₁₈H₃₄N₂O₆S

Peso molecolare: 406.54

Ref: ST-EA-CP-C26001