CAS 154598-52-4
:Efavirenz
Descrizione:
Efavirenz è un inibitore non nucleosidico della trascrittasi inversa (NNRTI) utilizzato principalmente nel trattamento dell'infezione da HIV. È caratterizzato dalla sua capacità di inibire l'enzima trascrittasi inversa, che è cruciale per la replicazione del virus HIV. Chimicamente, Efavirenz è un composto lipofilo, che contribuisce alle sue proprietà farmacocinetiche, inclusa una lunga emivita e la capacità di penetrare nel sistema nervoso centrale. La sostanza è tipicamente somministrata per via orale ed è spesso parte della terapia combinata per migliorare l'efficacia e ridurre il rischio di resistenza. Efavirenz è noto per i suoi effetti collaterali, che possono includere sintomi neuropsichiatrici, eruzioni cutanee e potenziali effetti sulla funzione epatica. Il suo meccanismo d'azione implica il legame con l'enzima trascrittasi inversa, portando all'interruzione della conversione dell'RNA virale in DNA. Il composto è classificato nell'elenco dei farmaci essenziali dell'Organizzazione Mondiale della Sanità, evidenziando la sua importanza nella salute globale. Come per qualsiasi farmaco, è essenziale monitorare gli effetti avversi e le interazioni farmacologiche durante il trattamento.
Formula:C14H9ClF3NO2
InChI:InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1
InChI key:InChIKey=XPOQHMRABVBWPR-ZDUSSCGKSA-N
SMILES:C(#CC1CC1)[C@@]2(C(F)(F)F)C=3C(NC(=O)O2)=CC=C(Cl)C3
Sinonimi:- (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
- (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-4-(2-Cyclopropylethynyl)-6-chloro-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-4-(Cyclopropylethynyl)-6-chloro-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (S)-Efavirenz
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (S)-
- Dmp 266
- Efavuirenz
- L 743726
- Stocrin
- Vedi altri sinonimi
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
18 prodotti.
Efavirenz
CAS:Formula:C14H9ClF3NO2Purezza:>98.0%(HPLC)(N)Colore e forma:White to Almost white powder to crystalPeso molecolare:315.68Efavirenz
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C14H9ClF3NO2Colore e forma:White Off-White Yellow Pink Crystalline PowderPeso molecolare:315.67 g/mol(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one
CAS:Formula:C14H9ClF3NO2Purezza:98%Colore e forma:SolidPeso molecolare:315.6750Efavirenz
CAS:Formula:C14H9ClF3NO2Purezza:≥ 98.0%Colore e forma:White to off-white crystalline powderPeso molecolare:315.68Efavirenz
CAS:Efavirenz (DMP 266) is an HIV-1 inhibitor, affecting reverse transcriptase and various cytochrome P450 enzymes.Formula:C14H9ClF3NO2Purezza:99.2% - 99.84%Colore e forma:White To Slightly Pink Crystalline PowderPeso molecolare:315.67(S)-Efavirenz
CAS:<p>Applications A nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>Formula:C14H9ClF3NO2Colore e forma:NeatPeso molecolare:315.68Efavirenz
CAS:Efavirenz is a non-nucleoside-based reverse transcriptase inhibitor (NNRTI) of the reverse transcriptase of HIV-1. It inhibits the viral enzyme reverse transcriptase by binding to its active site. In certain cell culture assays, efavirenz showed great efficiency when inhibiting wild-type HIV-1 replication with values of inhibition constant Ki between 2.97 to 17.60 mM in single mutation enzymes and 26.05 to 56.50 nM in double mutation. In the treatment of HIV, efavirenz has been studied in combination with emtricitabine and tenofovir disoproxil fumarate for ease of administration in some clinical studies. Recent in vitro cell studies indicated efavirenz is a potential treatment for pancreatic, prostate and triple-negative breast cancers due to its cytotoxicity against cancer cells, with an EC50 of 31.5 μM.Formula:C14H9ClF3NO2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:315.68 g/molEfavirenz - Bio-X ™
CAS:<p>Efavirenz is a non-nucleoside-based reverse transcriptase inhibitor (NNRTI) of the reverse transcriptase of HIV-1. It inhibits the viral enzyme reverse transcriptase by binding to its active site. In certain cell culture assays, Efavirenz showed great efficiency when inhibiting wild-type HIV-1 replication. In the treatment of HIV, Efavirenz has been studied in combination with Emtricitabine and Tenofovir disoproxil fumarate for ease of administration in some clinical studies. Recent in vitro cell studies indicated Efavirenz is a potential treatment for pancreatic, prostate and triple-negative breast cancers due to its cytotoxicity against cancer cells.Efavirenz is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formula:C14H9ClF3NO2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:315.67 g/mol(4S)-6-CHLORO-4-(CYCLOPROPYLETHYNYL)-1,4-DIHYDRO-4-(TRIFLUOROMETHYL)-2H-3,1-BENZOXAZIN-2-ONE
CAS:Purezza:98%Peso molecolare:315.6799927rac Efavirenz-8-d1
CAS:Prodotto controllatoFormula:C14DH8ClF3NO2Colore e forma:NeatPeso molecolare:316.681(S)-7,14-Dihydroxy Efavirenz
CAS:Prodotto controllatoFormula:C14H9ClF3NO4Colore e forma:NeatPeso molecolare:347.674
