CAS 155405-80-4

Metil 4-[2-(2-ammino-4,7-diidro-4-osso-3H-pirrolo[2,3-d]pirimidin-5-il)etil]benzoato

Descrizione:

Metil 4-[2-(2-ammino-4,7-diidro-4-osso-3H-pirrolo[2,3-d]pirimidin-5-il)etil]benzoato, con il numero CAS 155405-80-4, è un composto chimico caratterizzato dalla sua struttura complessa, che include un gruppo benzoato e un derivato di pirrolopirimidina. Questo composto tipicamente mostra proprietà associate sia a composti aromatici che eterociclici, contribuendo alla sua potenziale attività biologica. È probabile che sia solubile in solventi organici a causa della presenza del gruppo benzoato, mentre i suoi componenti eterociclici possono conferire interazioni specifiche con bersagli biologici. La presenza di un gruppo amminico suggerisce potenziale per legami idrogeno, il che può influenzare la sua reattività e interazione con altre molecole. Tali composti sono spesso studiati per le loro proprietà farmacologiche, inclusi ruoli potenziali come inibitori enzimatici o in altre applicazioni terapeutiche. In generale, le caratteristiche strutturali uniche di questo composto lo rendono un argomento di interesse in chimica medicinale e sviluppo di farmaci.

Formula: C₁₆H₁₆N₄O₃

InChI: InChI=1S/C16H16N4O3/c1-23-15(22)10-5-2-9(3-6-10)4-7-11-8-18-13-12(11)14(21)20-16(17)19-13/h2-3,5-6,8H,4,7H2,1H3,(H4,17,18,19,20,21)

InChI key: InChIKey=GDEKSBCRJKAARB-UHFFFAOYSA-N

SMILES: C(CC1=CC=C(C(OC)=O)C=C1)C=2C3=C(NC2)NC(N)=NC3=O

Sinonimi:

• 1H-Pyrrolo[2,3-d]pyrimidine, benzoic acid deriv.
• Methyl 4-[2-(2-Amino-4-Oxo-1,7-Dihydropyrrolo[4,5-E]Pyrimidin-5-Yl)Ethyl]Benzoate
• Methyl 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate
• Methyl 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate
• Methyl 4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate
• benzoic acid, 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-, methyl ester
• benzoic acid, 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-, methyl ester

Benzoic acid, 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-, methyl ester

CAS: 155405-80-4

Formula: C₁₆H₁₆N₄O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 312.3232

Ref: IN-DA001NVI

Methyl 4-(2-(2-Amino-4-Oxo-4,7-Dihydro-3H-Pyrrolo[2,3-d]Pyrimidin-5-yl)Ethyl)Benzoate

CAS: 155405-80-4

Methyl 4-(2-(2-Amino-4-Oxo-4,7-Dihydro-3H-Pyrrolo[2,3-d]Pyrimidin-5-yl)Ethyl)Benzoate

Purezza: 99%

Peso molecolare: 312.32g/mol

Ref: 54-OR1013826

Methyl 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate

CAS: 155405-80-4

Purezza: 95.0%

Peso molecolare: 312.3290100097656

Ref: 10-F213271

Methyl 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

CAS: 155405-80-4

Formula: C₁₆H₁₆N₄O₃

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow to Light orange powder to crystal

Peso molecolare: 312.33

Ref: 3B-M2426

Methyl 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate

CAS: 155405-80-4

Colore e forma: Neat

Ref: 86-MM1301.04

Pemetrexed Impurity 9

CAS: 155405-80-4

Formula: C₁₆H₁₆N₄O₃

Peso molecolare: 312.33

Ref: 4Z-P-6827

Pemetrexed acid methyl ester

Prodotto controllato

CAS: 155405-80-4

Applications An intermediate in the preparation of Pemetrexed Disodium (P219500) and its derivatives as anticancer agents.
References Min, T. et al.: Med. Chem. Res., 18, 495 (2009); Ma, Y. et al.: Zhong. Xin. Zaz., 16, 134 (2007);

Formula: C₁₆H₁₆N₄O₃

Colore e forma: Neat

Peso molecolare: 312.32

Ref: TR-A604950

Methyl 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate

CAS: 155405-80-4

Methyl 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate is a prodrug that is hydrolyzed to form the active drug pemetrexed disodium. The drug has been shown to be effective for the treatment of cancer and has been used in clinical trials for patients with lung cancer. The conversion of this prodrug to its active form occurs through a hydrolysis reaction at high temperature and by saponification with sodium hydroxide. Methyl 4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3 - d]pyrimidin -5 -yl)ethyl)benzoate can also be converted into its active form by enzymatic action using ester

Purezza: Min. 95%

Ref: 3D-FM41972