CAS 156161-89-6

B Q-788

Descrizione:

B Q-788, identificato dal suo numero CAS 156161-89-6, è un composto chimico che ha attirato l'attenzione nel campo della chimica medicinale, in particolare per le sue potenziali applicazioni terapeutiche. È caratterizzato come un antagonista selettivo di alcuni recettori, il che può contribuire ai suoi effetti farmacologici. Il composto è tipicamente studiato per il suo ruolo nella modulazione delle vie biologiche, influenzando potenzialmente condizioni legate alla salute cardiovascolare e ad altri processi fisiologici. La sua struttura molecolare include gruppi funzionali specifici che migliorano la sua affinità di legame e selettività per i recettori target. Inoltre, la solubilità, stabilità e biodisponibilità di B Q-788 sono fattori importanti che influenzano la sua efficacia e profilo di sicurezza in contesti di ricerca. Come molti composti in questa categoria, studi in corso mirano a chiarire il suo meccanismo d'azione, potenziale terapeutico e eventuali effetti collaterali associati, contribuendo a una migliore comprensione del suo ruolo nello sviluppo di farmaci e nelle applicazioni cliniche.

Formula: C₃₄H₅₀N₅O₇·Na

InChI: InChI=1/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43);/q;+1/p-1/t21-,22+,25-,26-,27+;/m1./s1

InChI key: InChIKey=IASLQTYUGYPLFB-FUKQNADPSA-N

SMILES: C([C@@H](NC([C@@H](NC(=O)N1[C@@H](C)CCC[C@H]1C)CC(C)(C)C)=O)C(N[C@H](CCCC)C(O)=O)=O)C=2C=3C(N(C(OC)=O)C2)=CC=CC3.[Na]

Sinonimi:

• <span class="text-smallcaps">D</smallcap>-Norleucine, N-[(cis-2,6-dimethyl-1-piperidinyl)carbonyl]-4-methyl-<smallcap>L</smallcap>-leucyl-1-(methoxycarbonyl)-<smallcap>D</span>-tryptophyl-, monosodium salt
• <span class="text-smallcaps">D</smallcap>-Norleucine, N-[N-[N-[(2,6-dimethyl-1-piperidinyl)carbonyl]-4-methyl-<smallcap>L</smallcap>-leucyl]-1-(methoxycarbonyl)-<smallcap>D</span>-tryptophyl]-, monosodium salt, cis-
• <span class="text-smallcaps">D</smallcap>-Norleucine, N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-<smallcap>L</smallcap>-leucyl-1-(methoxycarbonyl)-<smallcap>D</span>-tryptophyl-, monosodium salt
• <span class="text-smallcaps">D</smallcap>-Norleucine, N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-<smallcap>L</smallcap>-leucyl-1-(methoxycarbonyl)-<smallcap>D</span>-tryptophyl-, sodium salt (1:1)
• BQ-788, Sodium Salt
• Bq 788
• sodium (2R)-2-{[(2S)-2-({[(2R,6S)-2,6-dimethylpiperidin-1-yl]carbonyl}amino)-4,4-dimethylpentanoyl][1-(methoxycarbonyl)-D-tryptophyl]amino}hexanoate
• sodium N-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]carbonyl}-4-methyl-L-leucyl-N-[(1R)-1-carboxylatopentyl]-1-(methoxycarbonyl)-D-tryptophanamide
• D-Norleucine, N-[(cis-2,6-dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-, monosodium salt
• D-Norleucine, N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-, sodium salt (1:1)
• D-Norleucine, N-[N-[N-[(2,6-dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-, monosodium salt, cis-
• D-Norleucine, N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-, monosodium salt
• sodium,(2R)-2-[[(2R)-2-amino-3-(1-methoxycarbonylindol-3-yl)propanoyl]-[(2S)-2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4,4-dimethylpentanoyl]amino]hexanoate
• BQ-788 SYNTHETIC >97% ETB ENDOTHELIN REC EPT
• N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-
• 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle
• N-cis-2,6-dimethylpiperidinocarbonyl-L-γMeLeu-D-Trp(COOMe)-D-Nle-ONa
• BQ788 SODIUM SALT; BQ 788 SODIUM SALT
• DMpc-gaMMa-MeLeu-D-Trp(1-CO2CH3)-D-Nle.Na (DMpc : cis-2,6-DiMethylpiperidinocarbonyl)
• N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucinesodiumsalt
• N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt, 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle
• BQ789 Sodium Salt
• N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt
• 1-ELAIDYLPHOSPHOCHOLINE, >97%
• BQ-788 SODIUM

BQ-788

CAS: 156161-89-6

Bachem ID: 4058874.

Formula: C₃₄H₅₀N₅NaO₇

Purezza: 96.2%

Peso molecolare: 663.79

Ref: 01-4058874

BQ-788 Sodium

CAS: 156161-89-6

Formula: C₃₄H₅₀N₅NaO₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 663.7799

Ref: IN-DA001OKH

Sodium (R)-2-((R)-2-((S)-2-((2R,6S)-2,6-dimethylpiperidine-1-carboxamido)-4,4-dimethylpentanamido)-3-(1-(methoxycarbonyl)-1H-indol-3-yl)propanamido)hexanoate

CAS: 156161-89-6

Sodium (R)-2-((R)-2-((S)-2-((2R,6S)-2,6-dimethylpiperidine-1-carboxamido)-4,4-dimethylpentanamido)-3-(1-(methoxycarbonyl)-1H-indol-3-yl)propanamido)hexanoate

Purezza: 98%

Peso molecolare: 663.79g/mol

Ref: 54-OR1074812

BQ-788 sodium salt

CAS: 156161-89-6

BQ-788 sodium salt is a potent and selective antagonist of ETB receptor(ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells).

Formula: C₃₄H₅₁N₅NaO₇

Colore e forma: Solid

Peso molecolare: 664.8

Ref: TM-T10595L

BQ-788

CAS: 156161-89-6

Formula: C₃₄H₅₀N₅NaO₇

Peso molecolare: 663.78

Ref: 7W-GK9247

BQ 788

CAS: 156161-89-6

Applications BQ 788 is an endothelin type B (ETB) receptor antagonist and is a potential antidote for the cardiovascular toxicity with hypotension and bradycardia.
References Arici, M.A.A., et. al.: Hum. Exp. Toxicol., 32, 316 (2013)

Formula: C₃₄H₅₀N₅O₇·Na

Colore e forma: Neat

Peso molecolare: 663.78

Ref: TR-B676670

BQ 788-d2

Prodotto controllato

CAS: 156161-89-6

Formula: C₃₄D₂H₄₈N₅NaO₇

Colore e forma: Neat

Peso molecolare: 665.792

Ref: TR-B676672