CAS 158876-82-5

Rupatadina

Descrizione:

Rupatadina è un antistaminico di seconda generazione utilizzato principalmente per il trattamento di condizioni allergiche come la rinite allergica e l'orticaria. Funziona come un antagonista selettivo del recettore H1 dell'istamina, che aiuta ad alleviare i sintomi associati alle reazioni allergiche, come starnuti, prurito e naso che cola. Inoltre, Rupatadina presenta proprietà anti-infiammatorie inibendo il rilascio di mediatori pro-infiammatori. La sostanza è caratterizzata da effetti sedativi relativamente bassi rispetto agli antistaminici di prima generazione, rendendola adatta per un uso a lungo termine senza sonnolenza significativa. Rupatadina è tipicamente somministrato per via orale e ha un profilo farmacocinetico favorevole, inclusa una buona assorbimento e una emivita moderata, che consente una somministrazione una volta al giorno. La sua struttura chimica include un anello di piperidina, contribuendo alla sua attività farmacologica. In generale, Rupatadina è riconosciuto per la sua efficacia nella gestione dei sintomi allergici minimizzando la sedazione, rendendolo un'opzione preziosa nei regimi di trattamento delle allergie.

Formula: C₃₀H₃₀ClN₃O₄

InChI: InChI=1/C26H26ClN3.C4H4O4/c1-18-13-19(16-28-15-18)17-30-11-8-20(9-12-30)25-24-7-6-23(27)14-22(24)5-4-21-3-2-10-29-26(21)25;5-3(6)1-2-4(7)8/h2-3,6-7,10,13-16H,4-5,8-9,11-12,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI key: InChIKey=WUZYKBABMWJHDL-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCN(CC=5C=C(C)C=NC5)CC4)=CC1

Sinonimi:

• 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-
• 8-Chloro-6,11-Dihydro-11-[1-[(5-Methyl-3-Pyridyl)Methyl]-4-Piperidylidene]-5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine
• 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
• 8-chloro-11-{1-[(5-methylpyridin-3-yl)methyl]piperidin-4-ylidene}-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (2E)-but-2-enedioate
• Alergoliber
• Pafinur
• Rinialer
• Rupafin
• Rupax
• Rupatadine
• RUPATADINE FREE BASE
• RUPATADINEFUMARATE(FORR&DONLY)
• Rupafi
• 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2-β]pyridine (2E)-2-Butenedioate

5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-

CAS: 158876-82-5

Formula: C₂₆H₂₆ClN₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 415.9577

Ref: IN-DA001QYV

8-Chloro-11-(1-((5-Methylpyridin-3-Yl)Methyl)Piperidin-4-Ylidene)-6,11-Dihydro-5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine

CAS: 158876-82-5

8-Chloro-11-(1-((5-Methylpyridin-3-Yl)Methyl)Piperidin-4-Ylidene)-6,11-Dihydro-5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine

Purezza: 98%

Peso molecolare: 415.96g/mol

Ref: 54-OR1025672

Rupatadine

CAS: 158876-82-5

Formula: C₂₆H₂₆ClN₃

Colore e forma: Off-White Solid

Peso molecolare: 415.97

Ref: 4Z-R-423

Rupatadine

CAS: 158876-82-5

Rupatadine (UR-12592, rupatadine) is a potent and orally available dual antagonist of PAF and histamine H1 receptors ,allergic and anti-inflammatory.

Formula: C₂₆H₂₆ClN₃

Purezza: 99.87%

Colore e forma: Solid

Peso molecolare: 415.96

Ref: TM-T36618

Rupatadine

Prodotto controllato

CAS: 158876-82-5

Applications Rupatadine is an intermediate in the synthesis of Rupatadine (5-Methyl-3-pyridinyl)methyl)pyridinium Chloride (M326740). (5-Methy-3-pyridinyl)methyl-Rupatadine is an impurity of Rupatadine (R701650), a dual antagonist of histamine H1 and platelet-activating factor receptors
References Merlos, M., et al.: J. Pharmacol. Exp. Ther., 280, 114 (1997), Guadano, E.M., et al.: Allergy, 59, 766 (2004),

Formula: C₂₆H₂₆ClN₃

Colore e forma: Neat

Peso molecolare: 415.965

Ref: TR-R701653

8-Chloro-11-(1-((5-methylpyridin-3-yl)methyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

CAS: 158876-82-5

Rupatadine is a drug that has been shown to have antihistamine and anticholinergic properties. It is used for the treatment of allergic rhinitis, chronic idiopathic urticaria, and pruritus. Rupatadine has also been investigated for its potential use in the treatment of solid tumours. Rupatadine belongs to a class of drugs called histamine H1 receptor antagonists. In experimental models, it has been shown to inhibit the growth of certain types of cancer cells by blocking the activity of histamine receptors on cell membranes and inhibiting protein synthesis. The drug also inhibits cardiac potassium channels, which may lead to cardiac effects such as arrhythmias or heart block. Rupatadine fumarate is metabolized into rupatadine (RUP) by esterases and oxidized by cytochrome P450 enzymes or conjugated with glucuronic acid. This active form binds to proteins

Formula: C₂₆H₂₆ClN₃

Purezza: Min. 95%

Peso molecolare: 415.97 g/mol

Ref: 3D-IGA87682