CAS 158966-92-8

Montelukast

Descrizione:

Montelukast è un antagonista del recettore dei leucotrieni utilizzato principalmente nella gestione dell'asma e della rinite allergica. Funziona inibendo l'azione dei leucotrieni, che sono mediatori infiammatori che contribuiscono alla broncocostrizione e alla produzione di muco. Montelukast viene tipicamente somministrato per via orale ed è disponibile in varie formulazioni, tra cui compresse e forme masticabili. La sostanza ha una formula molecolare di C35H36ClNNaO3S e un peso molecolare di circa 608,2 g/mol. È caratterizzata dalla sua alta solubilità in acqua e dalla sua stabilità in condizioni normali di stoccaggio. Montelukast è generalmente ben tollerato, con effetti collaterali comuni che includono mal di testa, disturbi gastrointestinali e, in rari casi, cambiamenti dell'umore. La sua farmacocinetica indica che ha una emivita relativamente lunga, consentendo una somministrazione una volta al giorno. Il composto è classificato come un farmaco da prescrizione ed è spesso utilizzato come parte di un piano di gestione dell'asma completo, in particolare per i pazienti che sperimentano broncocostrizione indotta dall'esercizio o allergie stagionali.

Formula: C₃₅H₃₆ClNO₃S

InChI: InChI=1/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/t32-/m1/s1

InChI key: InChIKey=UCHDWCPVSPXUMX-TZIWLTJVSA-N

SMILES: C(S[C@H](CCC1=C(C(C)(C)O)C=CC=C1)C2=CC(/C=C/C3=NC4=C(C=C3)C=CC(Cl)=C4)=CC=C2)C5(CC(O)=O)CC5

Sinonimi:

• (1-{[(1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl)sulfanyl]methyl}cyclopropyl)acetic acid
• (2Beta,3Alpha,5Alpha,16Beta,17Beta)-3,17-Bis(Acetyloxy)-16-(1-Methylpiperidinium-1-Yl)-2-(Piperidin-1-Yl)Androstane Bromide
• (R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid
• 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid
• 1-[[[(R)-1-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid
• 2-[1-[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
• 2-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropyl]acetic acid
• Cyclopropaneacetic acid, 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-
• Cyclopropaneacetic acid, 1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-, [R-(E)]-
• Montelukas
• Velukast
• [1-[[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)vinyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic acid
• {1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid
• {1-[({(1R)-1-{3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid

Cyclopropaneacetic acid,1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-

CAS: 158966-92-8

Formula: C₃₅H₃₆ClNO₃S

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 586.1832

Ref: IN-DA00AOF9

(R,E)-2-(1-(((1-(3-(2-(7-Chloroquinolin-2-Yl)Vinyl)Phenyl)-3-(2-(2-Hydroxypropan-2-Yl)Phenyl)Propyl)Thio)Methyl)Cyclopropyl)Acetic Acid

CAS: 158966-92-8

(R,E)-2-(1-(((1-(3-(2-(7-Chloroquinolin-2-Yl)Vinyl)Phenyl)-3-(2-(2-Hydroxypropan-2-Yl)Phenyl)Propyl)Thio)Methyl)Cyclopropyl)Acetic Acid

Purezza: 99%

Peso molecolare: 586.18g/mol

Ref: 54-OR1025583

Montelukast

CAS: 158966-92-8

Montelukast

Purezza: ≥98%

Peso molecolare: 586.18g/mol

Ref: 54-BUP14076

Montelukast Sodium

CAS: 151767-02-1, 158966-92-8

Formula: C₃₅H₃₅ClNNaO₃S

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 608.17

Ref: 3B-M2340

Montelukast

CAS: 158966-92-8

Montelukast (Singular), oral asthma med, linked to rare liver injury.

Formula: C₃₅H₃₆ClNO₃S

Purezza: 98.56% - >99.99%

Colore e forma: Solid

Peso molecolare: 586.18

Ref: TM-T1677

Montelukast Impurity 32

CAS: 1093746-29-2, 158966-92-8

Formula: C₂₉H₂₆ClNO

Peso molecolare: 439.98

Ref: 4Z-M-3059

Montelukast - Bio-X ™

CAS: 158966-92-8

Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
Montelukast is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₃₅H₃₆ClNO₃S

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 586.19 g/mol

Ref: 3D-BM164608

Montelukast

CAS: 158966-92-8

Leukotriene receptor antagonist

Formula: C₃₅H₃₆ClNO₃S

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 586.18 g/mol

Ref: 3D-FM137467

Montelukast-d6 Sodium Salt

Prodotto controllato

CAS: 1093746-29-2, 151767-02-1, 158966-92-8

Formula: C₃₅H₂₉D₆ClNNaO₃S

Colore e forma: Neat

Peso molecolare: 614.2

Ref: TR-M568002

2’-Des(1-hydroxy-1-methylethyl)-2’-carboxy Montelukast Bissodium Salt

Prodotto controllato

CAS: 158966-92-8

Applications 2’-Des(1-hydroxy-1-methylethyl)-2’-carboxy Montelukast Bissodium Salt is an impurity of Montelukast Sodium Salt (M568000), a selective leukotriene D4-receptor antagonist. Used as an antiasthmatic.
References Labelle, M., et al.: Bioorg. Med. Chem. Lett., 5, 283 (1995); Jones, T.R., et al.: Can. J. Physiol. Pharmacol., 73, 191 (1995); Markham, A. and Faulds, D.: Drugs, 56, 251 (1998)

Formula: C₃₃H₂₈ClNNa₂O₄S

Colore e forma: Neat

Peso molecolare: 616.077

Ref: TR-D290480