CAS 159519-65-0

Enfuvirtide

Descrizione:

Enfuvirtide, noto anche con il suo codice di sviluppo T-20, è un peptide sintetico che funge da farmaco antiretrovirale utilizzato principalmente nel trattamento dell'infezione da HIV. È classificato come inibitore della fusione, il che significa che impedisce al virus di entrare nelle cellule umane interferendo con la fusione delle membrane virale e cellulare. Enfuvirtide viene somministrato tramite iniezione sottocutanea a causa della sua natura peptidica, che lo rende inadatto per la somministrazione orale. La sostanza ha una formula molecolare che riflette la sua struttura peptidica, composta da una sequenza di amminoacidi che contribuiscono alla sua attività biologica. Il suo meccanismo d'azione implica il legame con la subunità gp41 della glicoproteina di involucro dell'HIV, bloccando così i cambiamenti conformazionali necessari per l'ingresso virale. Enfuvirtide è tipicamente utilizzato in combinazione con altri agenti antiretrovirali in pazienti con esperienza di trattamento che hanno opzioni terapeutiche limitate. Gli effetti collaterali comuni possono includere reazioni nel sito di iniezione, nausea e affaticamento. In generale, Enfuvirtide rappresenta un componente critico nell'arsenale terapeutico contro l'HIV, in particolare nei casi di resistenza ai farmaci.

Formula: C₂₀₄H₃₀₁N₅₁O₆₄

InChI: InChI=1/C204H301N51O64/c1-20-102(15)166(253-195(310)137(75-100(11)12)239-200(315)150(93-258)251-190(305)143(82-112-90-215-95-219-112)248-203(318)167(103(16)21-2)254-196(311)138(76-101(13)14)240-201(316)151(94-259)252-204(319)168(105(18)260)255-197(312)139(221-106(19)261)78-108-45-47-113(262)48-46-108)202(317)233-131(58-68-164(280)281)178(293)228-130(57-67-163(278)279)182(297)250-149(92-257)198(313)232-125(52-62-155(210)266)179(294)245-145(84-157(212)268)191(306)229-124(51-61-154(209)265)175(290)224-122(49-59-152(207)263)173(288)226-126(53-63-159(270)271)176(291)222-120(43-31-33-69-205)172(287)244-144(83-156(211)267)192(307)231-127(54-64-160(272)273)177(292)225-123(50-60-153(208)264)174(289)227-128(55-65-161(274)275)180(295)235-134(72-97(5)6)185(300)237-133(71-96(3)4)184(299)230-129(56-66-162(276)277)181(296)236-135(73-98(7)8)187(302)247-147(86-165(282)283)194(309)223-121(44-32-34-70-206)171(286)241-140(79-109-87-216-117-40-28-25-37-114(109)117)183(298)220-104(17)170(285)249-148(91-256)199(314)238-136(74-99(9)10)186(301)242-142(81-111-89-218-119-42-30-27-39-116(111)119)189(304)246-146(85-158(213)269)193(308)243-141(80-110-88-217-118-41-29-26-38-115(110)118)188(303)234-132(169(214)284)77-107-35-23-22-24-36-107/h22-30,35-42,45-48,87-90,95-105,120-151,166-168,216-218,256-260,262H,20-21,31-34,43-44,49-86,91-94,205-206H2,1-19H3,(H2,207,263)(H2,208,264)(H2,209,265)(H2,210,266)(H2,211,267)(H2,212,268)(H2,213,269)(H2,214,284)(H,215,219)(H,220,298)(H,221,261)(H,222,291)(H,223,309)(H,224,290)(H,225,292)(H,226,288)(H,227,289)(H,228,293)(H,229,306)(H,230,299)(H,231,307)(H,232,313)(H,233,317)(H,234,303)(H,235,295)(H,236,296)(H,237,300)(H,238,314)(H,239,315)(H,240,316)(H,241,286)(H,242,301)(H,243,308)(H,244,287)(H,245,294)(H,246,304)(H,247,302)(H,248,318)(H,249,285)(H,250,297)(H,251,305)(H,252,319)(H,253,310)(H,254,311)(H,255,312)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)/t102-,103-,104-,105+,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,166-,167-,168-/m0/s1

Sinonimi:

• T-2
• Enfuvirtide(T-20)
• Enfurvitide(T-20)
• Pentafuside
• Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH{2}
• 1-{[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-(butan-2-yl)-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}prolyl-N~5~-(diaminomethylidene)ornithylglycinamide
• Enfuvirtide Acetate

Enfuvirtide

CAS: 159519-65-0

Enfuvirtide is a 36 amino acid peptide corresponding to a region of gp41, the transmembrane subunit of HIV-1 envelope protein. It belongs to the therapeutic class of fusion inhibitors and acts by binding to gp41 and impeding the conformational changes in gp41 necessary for fusion of the virus with the cell.

Formula: C₂₀₄H₃₀₁N₅₁O₆₄

Purezza: ≥ 94%

Colore e forma: White Powder

Peso molecolare: 4491.94

Ref: 01-4062216

L-Phenylalaninamide,N-acetyl-L-tyrosyl-L-threonyl-L-seryl-L-leucyl-L-isoleucyl-L-histidyl-L-seryl-L-leucyl-L-isoleucyl-L-a-glutamyl-L-a-glutamyl-L-seryl-L-glutaminyl-L-asparaginyl-L-glutaminyl-L-glutaminyl-L-a-glutamyl-L-lysyl-L-asparaginyl-L-a-glutamyl-L-glutaminyl-L-a-glutamyl-L-leucyl-L-leucyl-L-a-glutamyl-L-leucyl-L-a-aspart

CAS: 159519-65-0

Formula: C₂₀₄H₃₀₁N₅₁O₆₄

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 4491.8760

Ref: IN-DA01DQA6

Enfuvirtide T-20

CAS: 159519-65-0

Enfuvirtide T-20

Purezza: >97.0% as determined by (Typical Value in Batch COA)

Colore e forma: White Lyophilised Powder

Peso molecolare: 4,491.88g/mol

Ref: 54-BITP1540

Enfuvirtide

CAS: 159519-65-0

Enfuvirtide (INN) is an HIV fusion inhibitor, the first of a class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection.

Formula: C₂₀₄H₃₀₁N₅₁O₆₄

Purezza: 98%

Colore e forma: White To Off-White Amorphous Solid

Peso molecolare: 4491.945

Ref: TM-TP1332

Enfuvirtide

CAS: 159519-65-0

Formula: C₂₀₄H₃₀₁N₅₁O₆₄

Purezza: 95%~99%

Colore e forma: White to Off-white Powder

Peso molecolare: 4491.88

Ref: BP-BPPG026

Enfuvirtide

CAS: 159519-65-0

TFA salt. Enfuviritide is a bicyclic heterocycle that is used in the treatment of HIV/AIDS. It binds to the HIV-1 envelope protein, preventing it from binding to CD4+ cells and infecting them. Enfuviritide has been shown to be effective at increasing the levels of active antiretroviral therapy and has shown significant cytotoxicity against HIV-1 and other infectious viruses. This drug also inhibits viral life by binding to the viral envelope protein gp120 and preventing it from binding to CD4+ cells. However, this drug may have long-term toxicity and may cause drug interactions with other drugs that are metabolized by cytochrome P450 enzymes. Enfuviritide has inhibitory properties against a wide range of antimicrobial agents including Gram-positive bacteria, Gram-negative bacteria, fungi, protozoa, and enveloped viruses.

Formula: C₂₀₄H₃₀₁N₅₁O₆₄

Purezza: Min. 95%

Peso molecolare: 4,491.98 g/mol

Ref: 3D-ENF-3787-PI