CAS 16009-13-5

Hemin

Descrizione:

Hemin, con il numero CAS 16009-13-5, è un derivato dell'eme che gioca un ruolo significativo in vari processi biochimici. È caratterizzato dalla sua apparenza cristallina di colore marrone scuro a nero ed è solubile in solventi organici come il dimetilsolfossido (DMSO) e leggermente solubile in acqua, particolarmente a pH acido. Hemin è la forma ossidata dell'eme, che contiene un ione di ferro coordinato a un anello di porfirina. Questo composto è noto per la sua capacità di partecipare a reazioni redox e può agire come catalizzatore in vari percorsi biochimici. Hemin è spesso utilizzato in ambienti di laboratorio per studi relativi all'emoglobina e alla mioglobina, così come nella sintesi di altri composti contenenti eme. Inoltre, ha applicazioni in medicina, in particolare nel trattamento di alcune porfirie, dove aiuta a regolare la sintesi dell'eme. La sua stabilità e reattività lo rendono un composto prezioso sia in contesti di ricerca che clinici.

Formula: C₃₄H₃₀ClFeN₄O₄·2H

InChI: InChI=1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13?,27-14?,28-15?,29-14-,30-15-,31-16-,32-16?;;

InChI key: InChIKey=BTIJJDXEELBZFS-KKXYAJQKSA-K

SMILES: [Cl-][Fe+3]123[N-]4C5=CC6=[N]1C(=CC=7[N-]2C(C=C8[N]3=C(C=C4C(C)=C5CCC([O-])=O)C(C=C)=C8C)=C(C=C)C7C)C(C)=C6CCC([O-])=O.[H+]

Sinonimi:

• 1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionic acid ferrichloride
• 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, iron complex
• Chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]iron
• Chlorohemin
• Chloroprotoferriheme
• Chloroprotohemin
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N²¹,N²²,N²³,N²⁴]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, hydrogen (1:2), (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, hydrogen (1:2), (SP-5-13)-
• Ferric hemin
• Ferriheme
• Ferriheme chloride
• Ferriporphyrin chloride
• Ferriprotoporphyrin
• Ferriprotoporphyrin IX
• Ferriprotoporphyrin IX chloride
• Haemin
• Hemin
• Hemin IX
• Hemin chloride
• Hemina
• Hemine
• Iron(III) protoporphyrin chloride
• Iron, chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]-
• Kjb 003
• Panhematin
• Protoferriheme
• Protohemin
• Protohemin IX
• Protohemin chloride
• Teichmann's crystals
• Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24)-, hydrogen (1:2), (SP-5-13)-
• Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24)-, dihydrogen, (SP-5-13)-
• Alkaline Hematin D-575
• UNII-743LRP9S7N
• AI3-18784
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, dihydrogen, (SP-5-13)-
• Ferrihaem
• NSC 122707
• Teichmanns crystals
• CCRIS 7061

Hemin (porcine), 97+%

CAS: 16009-13-5

Hemin is used in cellular protection and control mechanism. It stimulates the synthesis of globulin. It is also used to study the bacterial strains and growth conditions, in the short-term colony assays and cell transfections. Further, it is used to treat the symptoms of various porphyrias. In addit

Formula: C₃₄H₃₂ClFeN₄O₄

Purezza: 97+%

Colore e forma: Dark purple or brown to black, Crystals or powder or crystalline powder

Peso molecolare: 651.95

Ref: 02-A11165

Hemin

CAS: 16009-13-5

Formula: C₃₄H₃₂ClFeN₄O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 651.9403

Ref: IN-DA00HYL2

Hemin, 95%

CAS: 16009-13-5

Formula: C₃₄H₃₂ClFeN₄O₄

Purezza: ≥ 95.0%

Colore e forma: Dark blue or dark green to brown-black powder

Peso molecolare: 651.95

Ref: 7W-GE0624

Hemin bovine

CAS: 16009-13-5

Hemin bovine

Formula: C₃₄H₃₂ClFeN₄O₄

Purezza: 97%

Peso molecolare: 651.95g/mol

Ref: 54-BI4570

Hemin

CAS: 16009-13-5

Hemin

Purezza: ≥95%

Peso molecolare: 651.94g/mol

Ref: 54-BUP18540

Hemin porcine

CAS: 16009-13-5

Hemin porcine

Formula: C₃₄H₃₂ClFeN₄O₄

Colore e forma: Dark Blue Powder

Peso molecolare: 651.94g/mol

Ref: 54-BIH1004

Hemin

CAS: 16009-13-5

Formula: C₃₄H₃₂ClFeN₄O₄

Purezza: >95%

Colore e forma: Dark Blue

Peso molecolare: 651.94

Ref: FT-H651-9

Hemin

CAS: 16009-13-5

Formula: C₃₄H₃₂ClFeN₄O₄

Purezza: >95.0%(T)

Colore e forma: Dark green to Dark purple to Black powder to crystal

Peso molecolare: 651.95

Ref: 3B-H0008

Hemin, 98%

CAS: 16009-13-5

Formula: C₃₄H₃₂ClFeN₄O₄

Purezza: ≥ 98%

Colore e forma: Dark blue to brown-black powder

Peso molecolare: 651.95

Ref: 7W-GE9985

Hemin

CAS: 16009-13-5

Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer.

Formula: C₃₄H₃₂ClFeN₄O₄

Purezza: 97.169% - 99.59%

Colore e forma: Dark Purple Crystalline Powder

Peso molecolare: 651.94

Ref: TM-T5515

Hemin

CAS: 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Formula: C₃₄H₃₂ClFeN₄O₄

Purezza: Min. 97 Area-%

Colore e forma: Powder

Peso molecolare: 651.94 g/mol

Ref: 3D-FH16318

Hemin

CAS: 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Formula: C₃₄H₃₂ClFeN₄O₄

Purezza: Min. 97.0 Area-%

Peso molecolare: 651.94 g/mol

Ref: 3D-H-1701

Hemin

CAS: 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Formula: C₃₄H₃₂ClFeN₄O₄

Purezza: 98.0 To 100.0 Area-%

Colore e forma: Powder

Peso molecolare: 651.94 g/mol

Ref: 3D-XH181795

Hemin Chloride (Technical grade)

CAS: 16009-13-5

Applications Hemin chloride is a porphyrin complex heme oxygenase-1 inducer with acts in cellular protection and control. At a concentration of 20 mM Hemin chloride demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. Hemin chloride has been noted to stimulate calcium-dependent K+ channels and modulate fluid transport and Na+ in the loop of henle in rat studies. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes, hemin chloride demonstrated anti-apoptotic, antiinflamatory and antioxidant properties. Through reactive oxygen species of ERK
References Vanova, K. et al.: BMC Cancer., 16, 309 (2016); Wang, X. et al.: ACS App. Mat. Inter., 9, 25387 (2017);

Formula: C₃₄H₃₂ClFeN₄O₄

Colore e forma: Neat

Peso molecolare: 651.94

Ref: TR-H245648

Hemin (Ferriprotoporphyrin IX chloride), min. 95%

CAS: 16009-13-5

Hemin (Ferriprotoporphyrin IX chloride), min. 95%

Formula: Fe(C₃₄H₃₂N₄O₄)Cl

Purezza: min. 95%

Colore e forma: black xtl.

Peso molecolare: 651.95

Ref: 08-26-1480

Hemin Chloride cryst. ex. Porcine extrapure, 98%

CAS: 16009-13-5

Formula: C₃₄H₃₂CIFeN₄O₄

Purezza: min. 98%

Colore e forma: Dark brownish black to dark blue to grey, Crystalline powder

Peso molecolare: 651.96

Ref: SR-98457

Hemin Chloride cryst. ex. Bovine extrapure, 98%

CAS: 16009-13-5

Formula: C₃₄H₃₂CIFeN₄O₄

Purezza: min. 98 %

Colore e forma: Dark brownish black, Crystalline powder

Peso molecolare: 651.96

Ref: SR-78372

Hemin

CAS: 16009-13-5

Purezza: 98%

Peso molecolare: 616.18

Ref: 10-F556533

Hemin-d6

Prodotto controllato

CAS: 16009-13-5

Formula: C₃₄D₆H₂₆ClFeN₄O₄

Colore e forma: Neat

Peso molecolare: 657.977

Ref: TR-H245647