CAS 16053-52-4

1-(2'-desossi-beta-treopentofuranosil)timina

Descrizione:

1-(2'-desossi-beta-treopentofuranosil)timina, con il numero CAS 16053-52-4, è un analogo di nucleoside che presenta una base di timina legata a uno zucchero di desossiribosio. Questo composto è caratterizzato dalla sua configurazione unica dello zucchero, specificamente la forma beta-treo, che lo distingue da altri nucleosidi. La presenza della porzione di desossiribosio indica che è un componente del DNA, e la base di timina contribuisce al suo ruolo nella struttura e funzione degli acidi nucleici. Questo composto è di interesse nella ricerca biochimica e farmaceutica, in particolare nello studio delle interazioni degli acidi nucleici e nello sviluppo di agenti antivirali o antitumorali. Le sue proprietà strutturali possono influenzare la sua attività biologica, stabilità e interazione con enzimi o altre biomolecole. Inoltre, la modifica del componente zuccherino può influenzare la capacità del composto di imitare nucleosidi naturali, potenzialmente impattando la sua incorporazione negli acidi nucleici e la sua efficacia complessiva nelle applicazioni terapeutiche.

Formula: C₁₀H₁₄N₂O₅

InChI: InChI=1/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7-,8-/m1/s1

SMILES: Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)O)c(=O)nc1O

Sinonimi:

• 1-(2'-Deoxy-beta-D-threo-pentofuranosyl)thymine
• 1-Dpft
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-threo-pentofuranosyl)-5-methyl-
• 1-(2-deoxypentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• 1-(2-deoxy-beta-D-threo-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• 1-(2'-Deoxy-beta-threopentofuranosyl)thymine
• beta-T 1-(2-Deoxy-b-D-xylofuranosyl)-5-methyluracil, Zidovudine impurity 6,Zidovudine impurity M
• Stavudine EP Impurity B (Zidovudine EP Impurity F)
• 1-(2'-DEOXY-SS-THREOPENTOFURANOSYL)THYMINE
• Zidovudine Impurity 6(Zidovudine EP Impurity F)
• Zidovudine EP Impurity F (Stavudine EP Impurity B)
• 1-(2-Deoxy--D-xylofuranosyl)-5-methyluracil
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-threo-pentofuranosyl)-5-methyl-
• Zidovudine EP Impurity F
• 1-(2-Deoxy-b-D-xylofuranosyl)-5-methyluracil
• 1-(2'-Deoxy-β-D-threo-pentofuranosyl)thymine
• 1-(2-Deoxy-beta-D-xylofuranosyl)-5-methyluracil
• 1-(2-Deoxy-beta-D-xylofuranosyl)-5-methyluracil, 3’-FddT, Alovudine
• Stavudine EP Impurity B
• 3'-β-Thymidine
• Stavudine Impurit Ⅳ: 1-(2-Deoxy-β-D-threo-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione( 3'-β-Thymidine)
• Zidovudine impurity M
• 1-(2-Deoxy-β-D-threopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• Stavudine Impurit Ⅳ: 1-(2-Deoxy-β-D-threo-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione( 3’-β-Thymidine)
• 1-((2R,4R,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione
• 3’-β-Thymidine
• Thymidine 3''-Epimer
• 1-((2S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Zidovudine Impurity F

CAS: 16053-52-4

Formula: C₁₀H₁₄N₂O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 242.23

Ref: 4Z-Z-087

1-(2-Deoxy-b-D-xylofuranosyl)-5-methyluracil

CAS: 16053-52-4

1-(2-Deoxy-b-D-xylofuranosyl)-5-methyluracil is a Nucleoside Derivative - Xylo-nucleoside.

Formula: C₁₀H₁₄N₂O₅

Colore e forma: Solid

Peso molecolare: 242.23

Ref: TM-TNU0990

3’-β-Thymidine-d3

Prodotto controllato

CAS: 16053-52-4

Applications An intermediate in the production of labelled fluorothymidine derivatives
References Roberts, G., et al.: Biochem. Pharmacol., 46, 2209 (1993), Hatano, A., et al.: Bioorg. Med. Chem., 16, 3866 (2008),

Formula: C₁₀H₁₁D₃N₂O₅

Colore e forma: Neat

Peso molecolare: 245.25

Ref: TR-T412007

3’-β-Thymidine

Prodotto controllato

CAS: 16053-52-4

Impurity Stavudine EP Impurity B
Applications 3’-β-Thymidine (Stavudine EP Impurity B) is an intermediate in the production of fluorothymidine and phosphorylase derivatives (1,2). Stavudine is used as an antiviral agent. Reverse transcriptase inhibitor (3).
References 1. Roberta, G. et al.: Biochem. Pharmacol. 1993 Dec 14;46(12):2209-18.2. Hatano, A. et al.: Bioorg. Med. Chem. 2008 Apr 1;16(7):3866-703. Santiprabhob, J. et al.: Biomed. Res. Int. 2017;2017:7481597.

Formula: C₁₀H₁₄N₂O₅

Colore e forma: Neat

Peso molecolare: 242.229

Ref: TR-T412005

1-(2-Deoxy-beta-D-xylofuranosyl)-5-methyluracil

CAS: 16053-52-4

1-(2-Deoxy-beta-D-xylofuranosyl)-5-methyluracil (1DXP) is a nucleoside that inhibits the enzyme UDP glucose pyrophosphorylase. This enzyme is involved in the synthesis of uridine nucleotides, which are required for RNA and DNA synthesis. 1DXP has been shown to be effective against hepatitis B virus and lymphocytic leukemia cells in vitro. The mechanism of action of 1DXP is not well understood, but it may be related to the inhibition of protein synthesis or cellular metabolism. It may also inhibit the enzyme amino transferase, which is important for the synthesis of aromatic amino acids such as phenylalanine and tyrosine.

Formula: C₁₀H₁₄N₂O₅

Purezza: Min. 95%

Peso molecolare: 242.23 g/mol

Ref: 3D-ID144724

Zidovudine EP Impurity F

CAS: 16053-52-4

Formula: C₁₀H₁₄N₂O₅

Peso molecolare: 242.23

Ref: ST-EA-CP-Z6006