CAS 1612888-66-0

RPT-835(alofanib)

CAS: 1612888-66-0

Formula: C₁₉H₁₅N₃O₆S

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 413.4039

Ref: IN-DA00AMH0

Alofanib

CAS: 1612888-66-0

Alofanib

Purezza: ≥98%

Peso molecolare: 413.4g/mol

Ref: 54-BUP08563

3-(N-(4-Methyl-2-Nitro-5-(Pyridin-3-Yl)Phenyl)Sulfamoyl)Benzoic Acid

CAS: 1612888-66-0

3-(N-(4-Methyl-2-Nitro-5-(Pyridin-3-Yl)Phenyl)Sulfamoyl)Benzoic Acid

Purezza: 97%

Peso molecolare: 413.4g/mol

Ref: 54-OR1025903

Alofanib

CAS: 1612888-66-0

Alofanib (RPT835) selectively inhibits FGFR2 in KATO III cells with IC50 <10 nM; doesn’t affect FGFR1/3 or FGF2-FGFR2 binding.

Formula: C₁₉H₁₅N₃O₆S

Purezza: 99.53% - 99.81%

Colore e forma: Solid

Peso molecolare: 413.4

Ref: TM-T5122

Alofanib

CAS: 1612888-66-0

Alofanib is a potent inhibitor of CDK4/6, which inhibits the phosphorylation of Rb and the release of E2F1. It also inhibits the phosphorylation of secretase, leading to reduced production of amyloid-beta peptides and suppression of tumor growth. Alofanib has been shown to inhibit tumor growth in animals with adrenocortical carcinoma and urothelial carcinoma. It has been studied in clinical trials for patients with cancer. The effective dose determined in mice was 0.5 mg/kg/day, but it is not yet known what the effective dose will be in humans.

Formula: C₁₉H₁₅N₃O₆S

Purezza: Min. 95%

Peso molecolare: 413.4 g/mol

Ref: 3D-MPC88866