CAS 161797-99-5

Etil 2-(4-idrossifenil)-4-metil-5-tiazolcarbossilato

Descrizione:

Etil 2-(4-idrossifenil)-4-metil-5-tiazolcarbossilato, con il numero CAS 161797-99-5, è un composto organico caratterizzato dai suoi gruppi funzionali tiazolici e fenolici. Questo composto appare tipicamente come una sostanza solida o cristallina ed è noto per le sue potenziali applicazioni in ambito farmaceutico e agrochimico grazie alla sua attività biologica. La presenza del gruppo estere etilico contribuisce alla sua solubilità nei solventi organici, mentre il gruppo idrossile sull'anello fenilico può migliorare la sua reattività e capacità di formare legami idrogeno. L'anello tiazolico è noto per il suo ruolo in vari processi biologici, rendendo questo composto di interesse nella chimica medicinale. La sua struttura molecolare suggerisce interazioni potenziali con bersagli biologici, il che potrebbe portare a vari effetti terapeutici. Inoltre, la stabilità e la reattività del composto possono essere influenzate da fattori ambientali come pH e temperatura, che sono considerazioni importanti nella sua applicazione e gestione. In generale, questo composto esemplifica la complessità e l'utilità dei composti eterociclici nella ricerca e sviluppo chimico.

Formula: C₁₃H₁₃NO₃S

InChI: InChI=1S/C13H13NO3S/c1-3-17-13(16)11-8(2)14-12(18-11)9-4-6-10(15)7-5-9/h4-7,15H,3H2,1-2H3

InChI key: InChIKey=LOCYSKNNFCGDTR-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C=1SC(=NC1C)C2=CC=C(O)C=C2

Sinonimi:

• 2-(4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxylate
• 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
• 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl ester
• 5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-methyl-, ethyl ester
• Ethyl 2-(4-HydroxyPhenyl)-4-Methyl Thiazole-5-Carboxylate
• Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
• Ethyl-2-(4-Hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate
• Ethyl2-(4-hydroxy phenyl)-4-methylthiazole-5-carboxylate
• Febuxostat N-2

5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-methyl-, ethyl ester

CAS: 161797-99-5

Formula: C₁₃H₁₃NO₃S

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 263.3122

Ref: IN-DA001VVY

Febuxostat Impurity 39

CAS: 161797-99-5

Formula: C₁₃H₁₃NO₃S

Colore e forma: White To Off-White Solid

Peso molecolare: 263.31

Ref: 4Z-F-3953

Ethyl 2-(4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxylate

CAS: 161797-99-5

Ethyl 2-(4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxylate

Purezza: 98%

Peso molecolare: 263.31g/mol

Ref: 54-OR1013139

Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate

CAS: 161797-99-5

Applications Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
References Li, X., et. al.: Lett. Org. Chem., 12, 217 (2015); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)

Formula: C₁₃H₁₃NO₃S

Colore e forma: Neat

Peso molecolare: 263.31

Ref: TR-E918910

Febuxostat Descyano Hydroxy Ethyl Ester

CAS: 161797-99-5

Formula: C₁₃H₁₃NO₃S

Peso molecolare: 263.31

Ref: ST-EA-CP-F7041

2-(4-Hydroxyphenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester

CAS: 161797-99-5

Formula: C₁₃H₁₃NO₃S

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 263.31

Ref: 10-F025271

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

CAS: 161797-99-5

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is an anticancer agent that belongs to the class of formamidines. It is synthesized by refluxing ethyl 4-hydroxyphenylacetic acid with hexamethylenetetramine and acetic acid in ethanol. After purification, it is converted to its active form by reacting with hydrochloric acid. Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate prevents the growth of cancer cells in culture by preventing DNA synthesis, which prevents RNA and protein synthesis. This agent has also been found to suppress paclitaxel production in cultured human breast cancer cells.

Formula: C₁₃H₁₃NO₃S

Purezza: Min. 95%

Peso molecolare: 263.31 g/mol

Ref: 3D-FE15829