CAS 163252-36-6

clevudina

Descrizione:

clevudina è un analogo nucleosidico antivirale principalmente studiato per il suo potenziale nel trattamento delle infezioni croniche da virus dell'epatite B (HBV). È caratterizzato dalla sua somiglianza strutturale con nucleosidi presenti in natura, il che gli consente di interferire con la replicazione virale. clevudina funziona inibendo l'enzima polimerasi virale, impedendo così la sintesi del DNA virale. Questo composto viene tipicamente somministrato per via orale e ha mostrato promesse negli studi clinici per la sua efficacia e il profilo di sicurezza. Il suo meccanismo d'azione implica l'incorporazione selettiva nel DNA virale, portando alla terminazione della catena durante la replicazione. clevudina è notevole per le sue proprietà farmacocinetiche relativamente favorevoli, inclusa una buona biodisponibilità e una emivita gestibile. Tuttavia, come molti agenti antivirali, può essere associato a effetti collaterali e la resistenza può svilupparsi con l'uso prolungato. La ricerca in corso continua a valutare la sua efficacia a lungo termine e il suo potenziale ruolo nelle terapie combinate per l'HBV. In generale, clevudina rappresenta un significativo progresso nell'arsenale farmacologico contro l'epatite B.

Formula: C₁₀H₁₃FN₂O₅

InChI: InChI=1/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m0/s1

InChI key: InChIKey=GBBJCSTXCAQSSJ-XQXXSGGOSA-N

SMILES: F[C@H]1[C@H](O[C@@H](CO)[C@@H]1O)N2C(=O)NC(=O)C(C)=C2

Sinonimi:

• 1-(2-Deoxy-2-fluoro-b-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
• 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• 1-(2-Deoxy-2-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
• 1-(2′-Deoxy-2′-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyluracil
• 2'-Fluoro-5-methyl-b-L-arabinofuranosyluracil
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyl-
• 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methyl-
• L-Fmau
• Levovir
• Clevudine
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-
• 1-(2′-Deoxy-2′-fluoro-β-L-arabinofuranosyl)-5-methyluracil
• Clevudine(Levovir)
• CLEVUDINE: 1-(2''-DEOXY-2''-FLUORO-BETA-L-ARABINOFURANOSYL)-5-METHYLURACIL
• 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione
• 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4
• 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-quinone
• 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-
• 1-(2''-DEOXY-2''-FLUORO--L-ARABINOFURANOSYL)-5-METHYLURACIL
• 1-[(2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
• CLEVUDINE: 1-(2''-DEOXY-2''-FLUORO-SS-L-ARABINOFURANOSYL)-5-METHYLURACIL
• CLEVUDINE, 1-(2'-DEOXY-2'-FLUORO-β-L-ARABINOFURANOSYL)-5-METHYLURACIL
• Clevudine USP/EP/BP
• 2'-Fluoro-5-methylarabinosyluracil
• 2'-F-2'-ara-dT

2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-

CAS: 163252-36-6

Formula: C₁₀H₁₃FN₂O₅

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 260.2190

Ref: IN-DA001TY5

Clevudine

CAS: 163252-36-6

Clevudine

Purezza: 98%

Peso molecolare: 260.22g/mol

Ref: 54-PC108998

Clevudine

CAS: 163252-36-6

Clevudine

Purezza: ≥98%

Peso molecolare: 260.22g/mol

Ref: 54-BUP06493

Clevudine

CAS: 163252-36-6

Formula: C₁₀H₁₃FN₂O₅

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 260.22

Ref: 7W-GP8280

Clevudine

CAS: 163252-36-6

Clevudine (Levovir) fights HBV, blocks viral DNA synthesis, and has a long half-life reducing relapse risk after treatment.

Formula: C₁₀H₁₃FN₂O₅

Purezza: 99.88% - 99.97%

Colore e forma: Solid

Peso molecolare: 260.22

Ref: TM-T6446

Clevudine

CAS: 163252-36-6

Clevudine is a synthetic pyrimidine analogue effective against the hepatitis B virus (HBV). Once inside the cell, it is converted into its active forms, clevudine monophosphate and clevudine triphosphate. The triphosphate form competes with thymidine to be incorporated into viral DNA, leading to DNA chain termination and inhibition of the HBV DNA polymerase (reverse transcriptase). Due to its long half-life, clevudine significantly reduces covalently closed circular DNA (cccDNA), making relapse less likely after treatment ends.

Formula: C₁₀H₁₃FN₂O₅

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 260.22 g/mol

Ref: 3D-NC09470

1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

CAS: 163252-36-6

Formula: C₁₀H₁₃FN₂O₅

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 260.221

Ref: 10-F235704

Clevudine

Prodotto controllato

CAS: 163252-36-6

Applications Antiviral drug, used for the treatment of Hepatitis B.
References Kwon, S., et al.: J. Virol., 84, 4494 (2010), Daga, P., et al.: Protein Sci., 19, 796 (2010),

Formula: C₁₀H₁₃FN₂O₅

Colore e forma: Neat

Peso molecolare: 260.22

Ref: TR-C574150