CAS 163680-77-1

Metansulfonato di pazufloxacina

Descrizione:

Il metanosulfonato di pazufloxacina è un antibiotico fluoroquinolone sintetico caratterizzato dalla sua attività antibatterica ad ampio spettro. È utilizzato principalmente nel trattamento di varie infezioni batteriche, in particolare quelle causate da organismi Gram-negativi e alcuni Gram-positivi. Il composto presenta un meccanismo d'azione che coinvolge l'inibizione della girasi del DNA batterico e della topoisomerasi IV, enzimi critici per la replicazione e la trascrizione del DNA. La pazufloxacina è nota per le sue favorevoli proprietà farmacocinetiche, tra cui una buona biodisponibilità orale e penetrazione nei tessuti, che ne migliorano l'efficacia terapeutica. La forma di sale di metanosulfonato migliora la sua solubilità e stabilità, rendendola adatta per la formulazione in varie forme di dosaggio. Inoltre, la pazufloxacina è stata studiata per il suo potenziale utilizzo nel trattamento delle infezioni delle vie respiratorie e delle vie urinarie. Come altre fluoroquinoloni, può essere associata a effetti collaterali, tra cui disturbi gastrointestinali e potenziali effetti sulla salute dei tendini. Nel complesso, il metanosulfonato di pazufloxacina rappresenta un'opzione preziosa nell'arsenale degli antibiotici, particolarmente nel contesto dell'aumento della resistenza agli antibiotici.

Formula: C₁₇H₁₉FN₂O₇S

InChI: InChI=1/C16H15FN2O4.CH4O3S/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22;1-5(2,3)4/h4-5,7H,2-3,6,18H2,1H3,(H,21,22);1H3,(H,2,3,4)/t7-;/m0./s1

InChI key: InChIKey=UDHGFPATQWQARM-FJXQXJEOSA-N

SMILES: O=C1C=2C3=C(C(=C(F)C2)C4(N)CC4)OC[C@H](C)N3C=C1C(O)=O.S(C)(=O)(=O)O

Sinonimi:

• (3S)-10-(1-Aminocyclopropyl)-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid Methanesulfonate
• (3S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methanesulfonate
• (S)-(-)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine -6-carboxylic acid monomethanesulfonate
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-, monomethanesulfonate
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, monomethanesulfonate (9CI)
• Pasil
• Pazucross
• Pazufloxacin Mesilate
• Pazufloxacin Mesylate
• Pazufloxacin Methanesulfonate
• T 3762
• (3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid,
• Pazufloxacin mesilate VETRANAL
• pazufloxaxin methanesulfonate
• Pazufloxacin Monomethanesulfonate
• 2,3-de)-1,4-benzoxazine-6-carboxylicacid,2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-7h-pyrido((s)-7h-pyrido(monomethanesulfonate
• (s)-yclopropyl)-9-fluoro-3-methyl-7-oxomonomethanesulfonate
• (3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid, T-3761,
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate (9CI)
• Pazufloxacin mesylate, Pazufloxacin methanesulfonate
• PAZUFLOXAXIN METHANESULFONATE 99%

Pazufloxacin Mesylate

CAS: 127045-41-4, 163680-77-1

Formula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Orange to Green powder to crystal

Peso molecolare: 414.40

Ref: 3B-P1962

(2S)-6-(1-aminocyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5,7,9(13),11-tetraene-11-carboxylic acid; methanesulfonic acid

CAS: 163680-77-1

Formula: C₁₇H₁₉FN₂O₇S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 414.4054

Ref: IN-DA001UB2

Pazufloxacin Mesylate

CAS: 163680-77-1

Pazufloxacin Mesylate (T-3762) is a fluoroquinolone antibiotic.

Formula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Purezza: 99.88% - 99.93%

Colore e forma: Crystalline Solid

Peso molecolare: 414.4

Ref: TM-T1620

Pazufloxacin Mesylate

CAS: 163680-77-1

Pazufloxacin Mesylate

Purezza: ≥98%

Peso molecolare: 414.4g/mol

Ref: 54-BUP14927

Pazufloxacin Mesylate

CAS: 163680-77-1

Pazufloxacin Mesylate

Purezza: 98%

Peso molecolare: 414.4g/mol

Ref: 54-PC109200

Pazufloxacin Mesylate

CAS: 163680-77-1

Formula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Colore e forma: White To Off-White Solid

Peso molecolare: 318.31 96.11

Ref: 4Z-P-198001

PAZUFLOXACIN MESILATE

CAS: 163680-77-1

Purezza: 95%

Peso molecolare: 414.399993896484

Ref: 10-F806744

Pazufloxacin mesylate

CAS: 163680-77-1

Formula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Colore e forma: Neat

Peso molecolare: 414.41

Ref: 04-C15896350

Pazufloxacin mesylate

CAS: 163680-77-1

Formula: C₁₆H₁₅FN₂O₄·CH₄SO₃

Peso molecolare: 414.41

Ref: 7W-GA7060

Pazufloxacin Mesilate RS

CAS: 163680-77-1

Colore e forma: White To Pale Yellow-White Solid Crystalline Powder

Ref: 2K-1112800021

Pazufloxacin Mesylate

Prodotto controllato

CAS: 163680-77-1

Applications A fluorinated quinolone antibiotic. Antibacterial.
References Fukuoka,Y., et al.: Antimicrob. Ag. Chemother., 37, 384 (1993), Todo, Y., et al.: Chem. Pharm. Bull., 42, 2569 (1994)

Formula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Colore e forma: Neat

Peso molecolare: 414.41

Ref: TR-P211000

Pazufloxacin mesylate

CAS: 163680-77-1

Pazufloxacin mesylate is an antimicrobial agent that inhibits bacterial growth by binding to bacterial DNA gyrase and topoisomerase IV. Pazufloxacin mesylate has been shown to have a synergistic effect with other antibiotics. It has been shown to be effective against a number of human pathogens, including Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria gonorrhoeae. Pazufloxacin mesylate is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. The inhibition of cell division by pazufloxacin mesilate may be due to the inhibition of rna synthesis and protein synthesis. This antibiotic also causes a decrease in locomotor activity in mice, which may be due to its ability to inhibit the release of inflammatory mediators

Formula: C₁₇H₁₉FN₂O₇S

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 414.41 g/mol

Ref: 3D-FP26772