CAS 163913-87-9

frammento di peptide di glicoproteina oligodendrocitica della mielina 35-55 ratto, topo

Descrizione:

Il frammento peptidico 35-55 della glicoproteina oligodendrocitaria della mielina (MOG) è un peptide sintetico derivato dalla glicoproteina oligodendrocitaria della mielina, che è un componente significativo della guaina mielinica nel sistema nervoso centrale. Questo peptide è spesso utilizzato nella ricerca relativa alla neuroimmunologia e alla sclerosi multipla, poiché gioca un ruolo nella risposta immunitaria e nei processi di demielinizzazione. Il numero CAS 163913-87-9 identifica questo specifico frammento peptidico, che consiste in una sequenza di amminoacidi in grado di elicitar una risposta immunitaria in modelli sperimentali, in particolare in ratti e topi. Le caratteristiche di questo peptide includono la sua capacità di legarsi a recettori specifici sulle cellule immunitarie, influenzando potenzialmente l'attivazione e la proliferazione delle cellule T. Inoltre, è spesso utilizzato negli studi per comprendere i meccanismi delle malattie autoimmuni e sviluppare strategie terapeutiche. La sua stabilità, solubilità e attività biologica sono fattori critici che i ricercatori considerano quando utilizzano questo peptide in contesti sperimentali.

Sinonimi:

• MOG 35-55 amide

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), Rat, Mouse

CAS: 163913-87-9

For cellular and molecular biology applications

Formula: C₁₁₈H₁₇₇N₃₅O₂₉S

Peso molecolare: 2582.0

Ref: 02-J66557

MOG (Rat, Mouse, 35-55)

CAS: 163913-87-9

Amino acids 35-55 derived from the Immunogenic Myelin Oligodendrocyte protein (MOG). Produced by oligodendrocytes, MOG is an integral part of the oligodendrocyte surface membrane, located in the central nervous system (CNS) and plays an important role in the maintenance and disintegration of the myelin sheath. Unique within their immunoglobulin superfamily, MOG is composed of a transmembrane hydrophobic domain, an extracellular immunoglobulin variable (IgV) domain, a short cytoplasmic loop and within the membrane bilayer there is a second hydrophobic region and after this, a cytoplasmic end. In addition to 218 amino acids of the mature MOG protein, it contains a 29 amino acids long signal peptide.
MOG has not only been found to be expressed in the CNS but also at low levels in the peripheral nervous system. Generally MOG is expressed during myelination and functions to maintain the myelin sheath’s structurally integrity through mediating interactions between the myelin and the immune system. This is possible due to its adhesion characteristics and its external location which makes it accessible to antibodies and T-cells. Furthermore is has been suggested that MOG is involved in regulating oligodendrocyte microtubule stability and it can be used as a differentiation marker for oligodendrocyte maturation.Myelin forms a lipid layer around neurons which insulates them. MOG has immunodmainant epitopes: 1-22; 35-55 and 92-106 and this is located at the dimer interface which is formed by MOG IgV domains forming a dimer. These MOG epitopes are recognized by encepalitogenic T cells as foreign antigens. As a result demyelination occurs and this happens in the disease state of Multiple Sclerosis (MS).
As MOG is associated with inflammatory demyelinating diseases within the CNS such as neuromyelitis optica spectrum disorders and acute disseminated encephalomyelitis, this MOG (35-55) product can be used to induce these disease states in animal models.
One-Letter Formula: MEVGWYRSPFSRVVHLYRNGK

Formula: C₁₁₈H₁₇₇N₃₅O₂₉S

Purezza: Min. 95%

Peso molecolare: 2,581.95 g/mol

Ref: 3D-PMG-3660-PI

MOG (35-55) acid Mouse, Rat

CAS: 163913-87-9

Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin (Ig) protein superfamily and is expressed exclusively in the central nervous system on the surface of myelin sheaths and oligodendrocyte processes. MOG is expressed at the onset of myelination, and therefore is a potential marker for oligodendrocyte maturation.MOG contains an extracellular domain, a transmembrane domain, a cytoplasmic loop, a membrane-associated region and a cytoplasmic tail.  MOG may function as a cell surface receptor or cell adhesion molecule.  Fifteen different alternatively spliced isoforms have been detected in humans. These are present either on the cell surface, the endoplasmic reticulum in the endocytic system, or in secreted form.The secreted form of MOG may trigger autoimmunity if released into the cerebrospinal fluid and periphery. MOG is thought to be a key target for autoantibodies and cell-mediated immune responses in inflammatory demyelinating diseases such as multiple sclerosis (MS) and is therefore widely studied in this field.The MOG (35-55) fragment is the most potent auto-antigenic region of MOG, and the most effective at inducing experimental autoimmune/allergic encephalomyelitis (EAE), an animal model that resembles MS. This peptide has a free carboxylic acid at the C-terminus, an amide version is also available in our catalogue.

Formula: C₁₁₈H₁₇₇N₃₅O₂₉S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 2,581.95 g/mol

Ref: 3D-CRB1000205