CAS 164656-23-9

Dutasteride

Descrizione:

Dutasteride è un inibitore sintetico della 5-alfa-reduttasi utilizzato principalmente nel trattamento dell'iperplasia prostatica benigna (IPB) e della calvizie androgenetica. Funziona inibendo la conversione del testosterone in diidrotestosterone (DHT), un ormone implicato nella crescita della prostata e nella perdita di capelli. Dutasteride è caratterizzato dalla sua alta lipofilia, che gli consente di penetrare efficacemente nelle membrane cellulari. Il composto viene tipicamente somministrato per via orale e ha una lunga emivita, il che contribuisce alla sua azione sostenuta nella riduzione dei livelli di DHT. È noto per i suoi potenziali effetti collaterali, che possono includere disfunzione sessuale, ginecomastia e cambiamenti nei livelli degli enzimi epatici. Inoltre, a causa del suo meccanismo d'azione, è controindicato nelle donne, in particolare durante la gravidanza, poiché può influenzare lo sviluppo fetale. La struttura chimica di Dutasteride include uno scheletro simile a uno steroide, essenziale per la sua attività biologica. Complessivamente, Dutasteride rappresenta un significativo progresso nella gestione delle condizioni legate alla DHT.

Formula: C₂₇H₃₀F₆N₂O₂

InChI: InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1

InChI key: InChIKey=JWJOTENAMICLJG-QWBYCMEYSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(NC(=O)C=C4)[H])(CC1)[H])[H])(CC[C@@H]2C(NC5=C(C(F)(F)F)C=CC(C(F)(F)F)=C5)=O)[H]

Sinonimi:

• (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
• (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
• (4aR,6aS,7S)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
• (4aR,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
• (5Alpha,17Beta)-N-{2,5-Bis(Trifluoromethyl)Phenyl}-3-Oxo-4-Azaandrost-L-Ene-17-Carboxamide
• (5α,17β)-N-[(2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5-androst-1-ene-17-carboxamide
• 1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
• 4-Azaandrost-1-ene-17-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-, (5α,17β)-
• Avodart
• Avolve
• Gg 745
• Gi 198745
• Veltride

Dutasteride

CAS: 164656-23-9

Colore e forma: Neat

Ref: 61-FOR1424.00

DUTASTERIDE FOR SYSTEM SUITABILITY CRS

CAS: 164656-23-9

DUTASTERIDE FOR SYSTEM SUITABILITY CRS

Formula: C₂₇H₃₀F₆N₂O₂

Colore e forma: White To Slightly Yellow. Powder., White To Slightly Yellow. Powder.

Peso molecolare: 528.5297

Ref: 41-Y0001603

DUTASTERIDE CRS

CAS: 164656-23-9

DUTASTERIDE CRS

Formula: C₂₇H₃₀F₆N₂O₂

Colore e forma: Added

Peso molecolare: 528.5297

Ref: 41-Y0001598

Dutasteride

CAS: 164656-23-9

Adrenal cortical hormones and their derivatives nesoi

Formula: C₂₇H₃₀F₆N₂O₂

Colore e forma: White Pale Yellow Powder

Peso molecolare: 528.22115

Ref: 45-1229922

1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-

CAS: 164656-23-9

Formula: C₂₇H₃₀F₆N₂O₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 528.5297

Ref: IN-DA001V0C

Dutasteride

CAS: 164656-23-9

Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic

Formula: C₂₇H₃₀F₆N₂O₂

Purezza: 99.58%

Colore e forma: White Crystalline Solid

Peso molecolare: 528.53

Ref: TM-T1499

Dutasteride

CAS: 164656-23-9

Formula: C₂₇H₃₀F₆N₂O₂

Colore e forma: White To Off-White Solid

Peso molecolare: 528.54

Ref: 4Z-D-351

Dutasteride

CAS: 164656-23-9

Dutasteride

Purezza: 99%

Peso molecolare: 528.534g/mol

Ref: 54-BI12116

Dutasteride

CAS: 164656-23-9

Dutasteride

Purezza: ≥98%

Peso molecolare: 528.53g/mol

Ref: 54-BUP15449

Dutasteride

CAS: 164656-23-9

Formula: C₂₇H₃₀F₆N₂O₂

Purezza: ≥ 98.0%

Colore e forma: White to almost white crystalline powder

Peso molecolare: 528.53

Ref: 7W-GP0383

Dutasteride-13C6

CAS: 164656-23-9

Formula: C₂₁₁₃C₆H₃₀F₆N₂O₂

Colore e forma: White To Off-White Solid

Peso molecolare: 534.49

Ref: 4Z-D-352

Dutasteride

CAS: 164656-23-9

Formula: C₂₇H₃₀F₆N₂O₂

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 528.54

Ref: 3B-D5973

Dutasteride

Prodotto controllato

CAS: 164656-23-9

Formula: C₂₇H₃₀F₆N₂O₂

Colore e forma: Neat

Peso molecolare: 528.53

Ref: 86-MM1424.00

Dutasteride Impurity 5

CAS: 164656-23-9

Formula: C₂₇H₃₁F₆NO₃

Colore e forma: White To Off-White Solid

Peso molecolare: 531.54

Ref: 4Z-D-3525

Dutasteride

Prodotto controllato

CAS: 164656-23-9

Applications Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.
References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),

Formula: C₂₇H₃₀F₆N₂O₂

Colore e forma: Neat

Peso molecolare: 528.53

Ref: TR-D735000

Dutasteride - Bio-X ™

CAS: 164656-23-9

Dutasteride is an androgenic compound and a 5α-reductase inhibitor that is used to treat benign prostatic hyperplasia (BPH) and male pattern baldness. Dutasteride reduces prostate volume and improves symptoms of BPH by inhibiting the enzyme 5α-reductase, which converts testosterone to dihydrotestosterone.

Formula: C₂₇H₃₀F₆N₂O₂

Purezza: (%) Min. 99%

Colore e forma: Powder

Peso molecolare: 528.53 g/mol

Ref: 3D-BD164398

Dutasteride

CAS: 164656-23-9

A dual irreversible inhibitor of 5α-reductase isoforms 5AR1 and 5AR2 with IC50 of 6 nM and 7 nM, respectively. It supresses the production of dihydrotestosterone and has been used for the treatment of benign prostatic hyperplasia, alopecia and hirsutism in women with polycystic ovary syndrome. In rodent models for Parkinson’s disease, Dutasteride reduced L-DOPA-induced dyskinesia without altering the therapeutic effect of L-DOPA.

Formula: C₂₇H₃₀F₆N₂O₂

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 528.53 g/mol

Ref: 3D-FD22629

Dutasteride

CAS: 164656-23-9

Formula: C₂₇H₃₀F₆N₂O₂

Purezza: 95.0%

Colore e forma: Solid

Peso molecolare: 528.539

Ref: 10-F079399