CAS 16561-29-8

Forbolo 12-miristato 13-acetato

Descrizione:

Forbolo 12-miristato 13-acetato (PMA) è un composto organico sintetico derivato dal prodotto naturale forbol, che si ottiene dai semi della pianta Jatropha. È classificato come un estere di forbol ed è noto per il suo ruolo come potente promotore tumorale e attivatore della proteina chinasi C (PKC). PMA è una polvere cristallina bianca o bianco sporco che è solubile in solventi organici come etanolo e dimetilsolfossido (DMSO), ma ha una solubilità limitata in acqua. Il composto mostra una varietà di attività biologiche, inclusa l'induzione della proliferazione e differenziazione cellulare, rendendolo uno strumento prezioso nella ricerca sul cancro e negli studi di biologia cellulare. PMA è spesso utilizzato in ambienti di laboratorio per studiare le vie di trasduzione del segnale e i meccanismi di tumorigenesi. Tuttavia, a causa dei suoi potenti effetti biologici, deve essere maneggiato con cura negli ambienti di ricerca. La sua struttura chimica presenta un gruppo miristato e un gruppo acetato, contribuendo alla sua reattività e proprietà biologiche.

Formula: C₃₆H₅₆O₈

InChI: InChI=1/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24?,27-,28?,30+,32+,34+,35+,36+/m0/s1

InChI key: InChIKey=PHEDXBVPIONUQT-RGYGYFBISA-N

SMILES: O(C(C)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)[C@H]2OC(CCCCCCCCCCCCC)=O)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]

Sinonimi:

• (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
• 1,6,8-Beta-Tetramethyl-L)-9A-Acetate9-Myristate
• 12-O-Tetradecanoylphorbol 13-acetate
• 12-O-Tetradecanoylphorbolacetate
• 12-O-Tetradekanoylphorbol-13-Acetat
• 12-Tetradecanoylphorbol 13-acetate
• 12-Tetradecanoylphorbol 13-monoacetate
• 12-Tetradecanoylphorbol13-Monoacetate
• 13-O-Acetylphorbol 12-myristate
• 1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv.
• 4β-Phorbol 12-myristate 13-acetate
• Factor A1
• Factor A1 (croton oil)
• Factor A₁
• Factor A₁ (croton oil)
• Myristic acid, 9-ester with 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9a-acetate, (+)-
• Nsc 262244
• PMA
• PMA (tumor promoter)
• Pd 616
• Phorbol 12-tetradecanoate 13-acetate
• Phorbol myristate acetate
• TPA
• TPA (phorbol derivative)
• Tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester
• Tetradecanoic acid, 9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester, [1aR-(1aα,1bβ,4aβ,7aα,7bα,8α,9β,9aα)]-
• Tetradecanoylphorbol acetate
• β-Phorbol 12-myristate 13-acetate
• 4)benz(1,2-e)azulen-5-one9a-acetate,(+)-ethyl-5h-cyclopropa(
• abeta,7balpha,9beta,9aalpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8alpha-tetram
• PHORBOL (12-MYRISTOYL-13-ACETYL)
• 8,9,9a-decahydro-4a-alpha,7b-beta,9-alpha,9a-beta-tetrahydroxy-3-(hydroxymethy
• PHORBOL 12-MYRISTATE 13-ACETATE
• 4BETA,9ALPHA,12BETA,13ALPHA,20-PENTA-HYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
• 4BETA-PHORBOL 12-MYRISTATE 13-ACETATE
• (1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE
• 5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-beta,1b-alpha,4,4a,7a-beta,7b,
• 12-TETRADECANOYL PHORBOL 13-ACETATE
• 4ALPHA,9ALPHA,12BETA,13ALPHA,20-PENTAHYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
• 13-o-acetylphorbol12-myristate

Phorbol 12-myristate 13-acetate, 95%

CAS: 16561-29-8

Activates protein kinase C and promotes skin tumors in mice

Formula: C₃₆H₅₆O₈

Purezza: 95%

Colore e forma: White to pale cream, Powder, film or foam, solid

Peso molecolare: 616.84

Ref: 02-J63916

Tetradecanoic acid, (1aR,​1bS,​4aR,​7aS,​7bS,​8R,​9R,​9aS)​-​9a-​(acetyloxy)​-​1a,​1b,​4,​4a,​5,​7a,​7b,​8,​9,​9a-​decahydro-​4a,​7b-​dihydroxy-​3-​(hydroxymethyl)​-​1,​1,​6,​8-​tetramethyl-​5-​oxo-​1H-​cyclopropa[3,​4]​benz[1,​2-​e]​azulen-​9-​yl ester

CAS: 16561-29-8

Formula: C₃₆H₅₆O₈

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 616.8250

Ref: IN-DA00AOO4

Phorbol 12-myristate 13-Acetate

CAS: 16561-29-8

Phorbol 12-myristate 13-Acetate

Purezza: 95%

Peso molecolare: 616.825g/mol

Ref: 54-OR1030780

Phorbol 12-myristate 13-acetate

CAS: 16561-29-8

Phorbol 12-myristate 13-acetate

Purezza: ≥98%

Peso molecolare: 616.83g/mol

Ref: 54-BUP08804

Phorbol 12-Myristate 13-Acetate

CAS: 16561-29-8

Phorbol 12-Myristate 13-Acetate

Formula: C₃₆H₅₆O₈

Purezza: 98%

Colore e forma: amorphous solid

Peso molecolare: 616.83g/mol

Ref: 54-BIP1020

Phorbol-12-Myristate-13-Acetate

CAS: 16561-29-8

Formula: C₃₆H₅₆O₈

Purezza: 95%~99%

Peso molecolare: 616.836

Ref: BP-BP0021

Phorbol 12-myristate 13-acetate

CAS: 16561-29-8

Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.

Formula: C₃₆H₅₆O₈

Purezza: 98.55% - >99.99%

Colore e forma: White To Off-White Solid

Peso molecolare: 616.83

Ref: TM-TQ0198

Phorbol 12-myristate 13-acetate

CAS: 16561-29-8

Formula: C₃₆H₅₆O₈

Purezza: (HPLC) ≥ 98.0%

Colore e forma: White to off-white solid

Peso molecolare: 616.83

Ref: 7W-GK8317

4Beta-Phorbol 12-Myristate 13-Acetate

CAS: 16561-29-8

Formula: C₃₆H₅₆O₈

Colore e forma: Neat

Peso molecolare: 616.82

Ref: TR-P353475

Phorbol-12-myristate-13-acetate

CAS: 16561-29-8

Phorbol-12-myristate-13-acetate is a phorbol ester that inhibits the activity of protein kinase C. It binds to the response element on DNA and blocks RNA synthesis, leading to cell death. Phorbol 12-myristate 13-acetate has been shown to inhibit the proliferation of human squamous cells in culture, which may be caused by its ability to inhibit the cell cycle. This drug also has been shown to inhibit the production of cytokines such as interleukin-1β and tumor necrosis factor α (TNFα) in human polymorphonuclear leukocytes (PMNLs).

Formula: C₃₆H₅₆O₈

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 616.83 g/mol

Ref: 3D-FP15184

Phorbol-12-myristate-13-acetate

CAS: 16561-29-8

M02249 - Phorbol-12-myristate-13-acetate

Formula: C₃₆H₅₆O₈

Purezza: 98%

Colore e forma: Amorphous solid in the form of a film/foam

Peso molecolare: 616.836

Ref: 10-M02249