CAS 168626-94-6

Cloridrato di conivaptan

Descrizione:

Cloridrato di conivaptan è un composto sintetico classificato come un antagonista duale dei recettori della vasopressina, che agisce specificamente sui recettori V1A e V2. È utilizzato principalmente nel trattamento di condizioni associate a iponatremia, in particolare nei pazienti con insufficienza cardiaca o sindrome da secrezione inadeguata di ormone antidiuretico (SIADH). La sostanza è tipicamente somministrata per via endovenosa ed è nota per la sua capacità di promuovere l'aquaresi, che è l'escrezione di acqua libera senza la perdita di elettroliti. Cloridrato di conivaptan è caratterizzato dalla sua relativamente bassa solubilità in acqua, il che può influenzare la sua formulazione e i metodi di somministrazione. Il composto ha una struttura molecolare specifica che contribuisce alla sua attività farmacologica ed è metabolizzato principalmente nel fegato, con una emivita che consente regimi di dosaggio efficaci. Come per qualsiasi farmaco, gli effetti collaterali potenziali possono includere ipotensione, squilibri elettrolitici e reazioni nel sito di infusione, richiedendo un attento monitoraggio durante il trattamento.

Formula: C₃₂H₂₆N₄O₂·HCl

InChI: InChI=1/C32H26N4O2.ClH/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22;/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37);1H

InChI key: InChIKey=BTYHAFSDANBVMJ-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(C3=C(CC1)N=C(C)N3)=CC=CC2)C4=CC=C(NC(=O)C5=C(C=CC=C5)C6=CC=CC=C6)C=C4.Cl

Sinonimi:

• Conivaptan Monohydrochloride
• N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-, monohydrochloride
• N-{4-[(2-Methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamidhydrochlorid
• N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide hydrochloride
• N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(3H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide hydrochloride (1:1)
• N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazépin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide chlorhydrate
• Vaprisol
• Ym 087
• [1,1'-biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-, monohydrochloride
• [1,1′-Biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-, hydrochloride (1:1)
• Conivaptan hydrochloride
• N-[4-[(4,5-Dihydro-2-MethyliMidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-Biphenyl]-2-carboxaMide Hydrochloride
• N-(4-(2-methyl-3,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide hydrochloride
• Conivaptan hydrochkoride
• Conivaptan Hydrochloride Q: What is the CAS Number of
• Conivaptan HCl
• Conivaptan HydrochlorideQ: What is
• Conivaptan HCI
• N-[4-(2-Methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide hydrochloride
• Conivaptan hydrochloride [usan]
• Conivaptan Hydrochloride Q: What is the storage condition of
• Conivaptan Hydrochloride Q: What are the applications of
• N-[4-(2-Methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamid
• Unii-75L57R6X36
• Conivaptan hydrochloride USP/EP/BP
• N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride
• Conivaptan hydrochloride, >=99%
• [1,1'-Biphenyl]-2-carboxamide,N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-,hydrochloride
• N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-biphenyl]-2-carboxamide, hydrochloride (1:1)

[1,1'-Biphenyl]-2-carboxamide, N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-, hydrochloride (1:1)

CAS: 168626-94-6

Formula: C₃₂H₂₇ClN₄O₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 535.0354

Ref: IN-DA001Y6H

Conivaptan hydrochloride

CAS: 168626-94-6

Conivaptan hydrochloride

Purezza: ≥98%

Peso molecolare: 535.04g/mol

Ref: 54-BUP10683

Conivaptan HCl

CAS: 168626-94-6

Conivaptan HCl

Purezza: 99%

Peso molecolare: 535.04g/mol

Ref: 54-OR1023871

Conivaptan HCl

CAS: 168626-94-6

Formula: C₃₂H₂₆N₄O₂·HCl

Colore e forma: White To Off-White Solid

Peso molecolare: 498.59 36.46

Ref: 4Z-C-230001

Conivaptan Hydrochloride

Prodotto controllato

CAS: 168626-94-6

Formula: C₃₂H₂₆N₄O₂·ClH

Colore e forma: Neat

Peso molecolare: 535.04

Ref: 86-MM3580.00

Conivaptan hydrochloride

CAS: 168626-94-6

Conivaptan hydrochloride (Vaprisol) is an orally active vasopressin V2 and V1A receptor antagonist, used in the therapy of hypervolemic hyponatremia and

Formula: C₃₂H₂₆N₄O₂·HCl

Purezza: 98.33% - 99.86%

Colore e forma: Solid

Peso molecolare: 535.04

Ref: TM-T6453

Conivaptan Hydrochloride

Prodotto controllato

CAS: 168626-94-6

Applications Used in treatment of congestive heart failure.
References Mao, Z., et al.: Clin. Ther., 31, 1542 (2009), Arai, Y., et al.: J. Pharm. Sci., 109, 53 (2009),

Formula: C₃₂H₂₆N₄O₂·ClH

Colore e forma: Neat

Peso molecolare: 535.04

Ref: TR-C384700

Conivaptan hydrochloride

Prodotto controllato

CAS: 168626-94-6

Conivaptan hydrochloride is a selective, orally active vasopressin receptor antagonist that has been shown to be effective in the treatment of congestive heart failure. Conivaptan hydrochloride is used in experimental models to study its efficacy and safety. The long-term efficacy of conivaptan hydrochloride was demonstrated in a chronic oral study with rats. Optimum concentrations for conivaptan hydrochloride are between 0.5 and 2 mg/kg body weight, which should be administered three times daily. In patients with hepatic impairment, the concentration–time curve of conivaptan hydrochloride may be affected so that higher doses are required to achieve the desired effect. This drug also interacts with drugs such as warfarin, beta blockers, or calcium channel blockers. Patients with high body mass index or systolic pressure should not use this medication because it can lead to serious side effects.

Formula: C₃₂H₂₇ClN₄O₂

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 535.04 g/mol

Ref: 3D-FC20552

Conivaptan hydrochloride

CAS: 168626-94-6

Purezza: 95.0%

Colore e forma: Solid

Peso molecolare: 535.0399780273438

Ref: 10-F361967