CAS 170729-80-3

Aprepitant

Descrizione:

Aprepitant è un antagonista selettivo del recettore della neurochinina-1 (NK1), utilizzato principalmente nella prevenzione della nausea e del vomito associati alla chemioterapia e alla chirurgia. È classificato come una piccola molecola e viene spesso somministrato per via orale. Aprepitant mostra un'alta affinità per il recettore NK1, che gioca un ruolo cruciale nella risposta emetica mediata dalla sostanza P, un neuropeptide coinvolto nella percezione del dolore e nell'infiammazione. La sostanza è caratterizzata dalla sua relativamente bassa solubilità in acqua, che influisce sulla sua formulazione e biodisponibilità. Aprepitant è tipicamente utilizzato in combinazione con altri agenti antiemetici per migliorare l'efficacia terapeutica. La sua farmacocinetica prevede un ampio metabolismo nel fegato, principalmente attraverso il sistema del citocromo P450, portando a potenziali interazioni farmacologiche. Gli effetti collaterali comuni possono includere affaticamento, vertigini e disturbi gastrointestinali. In generale, Aprepitant rappresenta un significativo progresso nella gestione della nausea e del vomito indotti dalla chemioterapia, migliorando la qualità della vita dei pazienti sottoposti a trattamento per il cancro.

Formula: C₂₃H₂₁F₇N₄O₃

InChI: InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1

InChI key: InChIKey=ATALOFNDEOCMKK-OITMNORJSA-N

SMILES: C(N1[C@H]([C@@H](O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)OCC1)C3=CC=C(F)C=C3)C4=NNC(=O)N4

Sinonimi:

• 3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-
• 3H-1,2,4-Triazol-3-one, 5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-, [2R-[2α(R*),3α]]-
• 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one
• 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,
• 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
• 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend
• 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1,2-dihydro-3H-1,2,4-triazol-3-one
• Emend
• L 754030
• Mk 869
• Mk-0869

Aprepitant

CAS: 170729-80-3

Formula: C₂₃H₂₁F₇N₄O₃

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 534.43

Ref: 3B-A3135

Aprepitant impurity standard

CAS: 170729-80-3

Aprepitant impurity standard

Colore e forma: Off White Solid

Ref: 47-1148

APREPITANT CRS

CAS: 170729-80-3

APREPITANT CRS

Formula: C₂₃H₂₁F₇N₄O₃

Peso molecolare: 534.4267

Ref: 41-Y0001825

Aprepitant

CAS: 170729-80-3

Aprepitant

Formula: C₂₃H₂₁F₇N₄O₃

Purezza: 99.9%

Colore e forma: White. To. Beige

Peso molecolare: 534.15019

Ref: 47-1138

Aprepitant

CAS: 170729-80-3

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₂₃H₂₁F₇N₄O₃

Colore e forma: White Off-White Powder

Peso molecolare: 534.15019

Ref: 45-1041904

5-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,3-dihydro-1H-1,2,4-triazol-3-one

CAS: 170729-80-3

Formula: C₂₃H₂₁F₇N₄O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 534.4267

Ref: IN-DA0034H4

Aprepitant

CAS: 170729-80-3

Formula: C₂₃H₂₁F₇N₄O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 534.43

Ref: 4Z-A-321

Aprepitant

CAS: 170729-80-3

Aprepitant

Purezza: 99%

Peso molecolare: 534.43g/mol

Ref: 54-PC109217

Aprepitant

CAS: 170729-80-3

Aprepitant

Purezza: ≥98%

Peso molecolare: 534.43g/mol

Ref: 54-BUP15404

Aprepitant

CAS: 170729-80-3

Formula: C₂₃H₂₁F₇N₄O₃

Purezza: (HPLC) ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 534.43

Ref: 7W-GP4641

Aprepitant Impurity 31

CAS: 170729-80-3

Formula: C₂₇H₂₄F₇NO₂

Colore e forma: White To Off-White Solid

Peso molecolare: 527.49

Ref: 4Z-A-3212

Aprepitant

Prodotto controllato

CAS: 170729-80-3

Formula: C₂₃H₂₁F₇N₄O₃

Colore e forma: Neat

Peso molecolare: 534.43

Ref: 86-MM3251.00

Aprepitant

CAS: 170729-80-3

Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist.

Formula: C₂₃H₂₁F₇N₄O₃

Purezza: 98% - 99.68%

Colore e forma: Off-White To Light Yellow Cyrstalline Solid

Peso molecolare: 534.43

Ref: TM-T1743

Aprepitant

Prodotto controllato

CAS: 170729-80-3

Applications Aprepitant is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3).
References (1) Takemoto, H., et al.: nt J Clin Oncol (2016) (2) Bayati, S., et al.: Eur J Pharmacol. 791, 274 (2016) (3) Navari, R.M.: Expert Rev Anticancer Ther. 4, 715 (2004)

Formula: C₂₃H₂₁F₇N₄O₃

Colore e forma: Off-White

Peso molecolare: 534.43

Ref: TR-A729800

Aprepitant

CAS: 170729-80-3

Aprepitant is a neurokinin-1 receptor antagonist. It is an antiemetic which suppresses nausea and vomiting and has proven to be especially useful alongside cancer chemotherapy and as a tool in cancer-related studies. Aprepitant binds to the neurokinin-1 receptor in the brain, preventing it from binding to substance P. This prevents substance P from stimulating nerves in the vomiting center of the brain, reducing feelings of nausea and vomiting. Aprepitant has been shown to be effective against HIV infection, with no major side effects. The use of aprepitant for HIV therapy may be limited due to its ability to cause serious liver damage when taken with other drugs that are metabolized by cytochrome P450 enzymes.

Formula: C₂₃H₂₁F₇N₄O₃

Purezza: Min. 98%

Colore e forma: White Off-White Powder

Peso molecolare: 534.43 g/mol

Ref: 3D-FA17962

Fosaprepitant Dimeglumine Impurity C

CAS: 170729-80-3

Formula: C₂₃H₂₁F₇N₄O₃

Peso molecolare: 534.43

Ref: ST-EA-CP-F36003

Aprepitant - Bio-X ™

CAS: 170729-80-3

Aprepitant is a neurokinin-1 receptor antagonist. It is an antiemetic which suppresses nausea and vomiting and has proven to be especially useful alongside cancer chemotherapy and as a tool in cancer-related studies. Aprepitant binds to the neurokinin-1 receptor in the brain, preventing it from binding to substance P. This prevents substance P from stimulating nerves in the vomiting center of the brain, reducing feelings of nausea and vomiting. Aprepitant has been shown to be effective against HIV infection, with no major side effects. The use of aprepitant for HIV therapy may be limited due to its ability to cause serious liver damage when taken with other drugs that are metabolized by cytochrome P450 enzymes.

Formula: C₂₃H₂₁F₇N₄O₃

Purezza: Min. 98 Area-%

Peso molecolare: 534.43 g/mol

Ref: 3D-BA164216