CAS 170809-51-5

astressina

Descrizione:

astressina, con il numero CAS 170809-51-5, è un peptide sintetico che agisce come antagonista del fattore di rilascio della corticotropina (CRF). È utilizzato principalmente nella ricerca per studiare il ruolo del CRF nelle risposte allo stress e nei processi fisiologici correlati. astressina è caratterizzato dalla sua capacità di inibire le azioni del CRF, che è coinvolto nell'asse ipotalamo-ipofisi-surrene (HPA) e gioca un ruolo cruciale nella risposta del corpo allo stress. Il peptide viene tipicamente somministrato in contesti sperimentali per indagare i suoi effetti su ansia, depressione e altri disturbi correlati allo stress. La struttura di astressina consiste in una sequenza di amminoacidi che conferisce la sua attività biologica, ed è spesso utilizzato in modelli animali per esplorare potenziali applicazioni terapeutiche. Grazie alla sua azione specifica sui recettori del CRF, astressina è prezioso negli studi farmacologici volti a comprendere i meccanismi dello stress e sviluppare trattamenti per condizioni correlate allo stress.

Formula: C₁₆₁H₂₆₉N₄₉O₄₂

InChI: InChI=1/C161H269N49O42/c1-23-27-41-96(189-145(239)107(52-59-123(217)218)199-152(246)114(71-84(13)14)207-157(251)126(85(15)16)208-147(241)108(53-60-124(219)220)197-140(234)102(47-38-66-179-161(172)173)193-151(245)112(69-82(9)10)204-153(247)113(70-83(11)12)205-155(249)116(74-94-77-175-79-181-94)201-134(228)95(163)72-92-39-30-29-31-40-92)135(229)182-88(19)130(224)186-100(45-36-64-177-159(168)169)136(230)183-89(20)131(225)188-106(51-58-122(215)216)144(238)195-104(49-56-119(165)212)146(240)202-110(67-80(5)6)149(243)185-90(21)132(226)187-103(48-55-118(164)211)143(237)196-105-50-57-121(214)176-63-35-33-44-99(192-154(248)115(73-93-76-174-78-180-93)200-133(227)91(22)184-137(105)231)142(236)206-117(75-120(166)213)156(250)194-101(46-37-65-178-160(170)171)139(233)190-98(43-32-34-62-162)141(235)203-111(68-81(7)8)150(244)191-97(42-28-24-2)138(232)198-109(54-61-125(221)222)148(242)210-128(87(18)26-4)158(252)209-127(129(167)223)86(17)25-3/h29-31,39-40,76-91,95-117,126-128H,23-28,32-38,41-75,162-163H2,1-22H3,(H2,164,211)(H2,165,212)(H2,166,213)(H2,167,223)(H,174,180)(H,175,181)(H,176,214)(H,182,229)(H,183,230)(H,184,231)(H,185,243)(H,186,224)(H,187,226)(H,188,225)(H,189,239)(H,190,233)(H,191,244)(H,192,248)(H,193,245)(H,194,250)(H,195,238)(H,196,237)(H,197,234)(H,198,232)(H,199,246)(H,200,227)(H,201,228)(H,202,240)(H,203,235)(H,204,247)(H,205,249)(H,206,236)(H,207,251)(H,208,241)(H,209,252)(H,210,242)(H,215,216)(H,217,218)(H,219,220)(H,221,222)(H4,168,169,177)(H4,170,171,178)(H4,172,173,179)/t86-,87-,88-,89-,90-,91-,95+,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,126-,127-,128-/m0/s1

Sinonimi:

• H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2

Astressin

CAS: 170809-51-5

The Glu³⁰ to Lys³³ lactam bridge constrains astressin in an α-helical conformation which seems to be responsible for its especially high CRF antagonist activity. Astressin is 100 times more potent than α-helical CRF (9-41) at inhibiting ACTH secretion in vitro, and more than 10 times more potent in vivo than any other CRF antagonist reported to date.

Formula: C₁₆₁H₂₆₉N₄₉O₄₂

Purezza: 97.4%

Colore e forma: White Powder

Peso molecolare: 3563.24

Ref: 01-4026664

Astressin trifluoroacetate salt H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 trifluoroacetate salt

CAS: 170809-51-5

Formula: C₁₆₁H₂₆₉N₄₉O₄₂

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 3563.1617

Ref: IN-DA01E6VT

Astressin

CAS: 170809-51-5

Formula: C₁₆₁H₂₆₉N₄₉O₄₂

Peso molecolare: 3563.16

Ref: 7W-GK2573

Astressin

CAS: 170809-51-5

Astressin is a truncated CRF analog; binds strongly to receptor's extracellular domain, likely acting as a neutral competitive antagonist.

Formula: C₁₆₁H₂₆₉N₄₉O₄₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 3563.16

Ref: TM-TP1448

Astressin trifluoroacetate salt

CAS: 170809-51-5

Astressin trifluoroacetate salt H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln is a cyclic peptide that has been shown to have biological properties as an inhibitor of cyclases. Astressin has shown efficacy in treating some types of autoimmune diseases and bowel diseases, although it is not effective against all types of these disorders. Astressin also has receptor activity and can induce locomotor activity. This compound has been shown to be an inhibitor of the Toll like receptor 4 (TLR4). In this role, astressin blocks the inflammatory response by preventing the binding of endotoxin to TLR4 receptors on cells.

Formula: C₁₆₁H₂₆₉N₄₉O₄₂

Purezza: Min. 95%

Peso molecolare: 3,563.16 g/mol

Ref: 3D-FA108999