CAS 171228-49-2
:Posaconazolo
Descrizione:
Posaconazolo è un agente antifungino triazolico utilizzato principalmente per la prevenzione e il trattamento delle infezioni fungine, in particolare nei pazienti immunocompromessi. Mostra un ampio spettro di attività contro vari funghi, comprese le specie di Candida e Aspergillus. La struttura chimica di Posaconazolo presenta un anello triazolico, che è cruciale per il suo meccanismo d'azione, poiché inibisce l'enzima lanosterolo 14α-demetilasi, interrompendo la sintesi dell'ergosterolo nelle membrane cellulari fungine. Questo porta a un aumento della permeabilità della membrana e, in ultima analisi, alla morte cellulare. Posaconazolo è caratterizzato dalla sua relativamente bassa solubilità in acqua, che può influenzare la sua biodisponibilità; tuttavia, è disponibile in varie formulazioni, tra cui sospensione orale e compresse a rilascio ritardato. Il farmaco viene metabolizzato principalmente nel fegato e la sua farmacocinetica può essere influenzata da fattori come l'assunzione di cibo e farmaci concomitanti. Gli effetti collaterali comuni possono includere disturbi gastrointestinali e aumenti degli enzimi epatici. In generale, Posaconazolo è un'opzione terapeutica vitale nella gestione delle infezioni fungine invasive, in particolare nelle popolazioni ad alto rischio.
Formula:C37H42F2N8O4
InChI:InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1
InChI key:InChIKey=RAGOYPUPXAKGKH-XAKZXMRKSA-N
SMILES:C([C@@]1(C[C@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N([C@H]([C@H](C)O)CC)N=C5)CO1)C6=C(F)C=C(F)C=C6)N7C=NC=N7
Sinonimi:- (2xi)-1,4-anhydro-2,3,5-trideoxy-4-(2,4-difluorophenyl)-2-({4-[4-(4-{1-[(2S,3S)-2-hydroxypentan-3-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenoxy}methyl)-5-(1H-1,2,4-triazol-1-yl)-D-glycero-pentitol
- 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-<span class="text-smallcaps">D</span>-threo-pentitol
- 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
- 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
- <span class="text-smallcaps">D</span>-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
- Hydroxypropyl]-2,4-Dihydro-3H-1,2,4-Triazol-3-One
- Noxafil
- Posaconazole SP
- Posaconazole for research
- Sch 56592
- D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
- 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-(1-ethyl-2-hydroxypropyl)-2,4-dihydro-, [3R-[3α(1S*,2S*),5α]]-
- Vedi altri sinonimi
Ordinare per
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19 prodotti.
Posaconazole
CAS:Formula:C37H42F2N8O4Purezza:>98.0%(HPLC)Colore e forma:White to Light yellow powder to crystalPeso molecolare:700.79Posaconazole
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C37H42F2N8O4Colore e forma:White PowderPeso molecolare:700.329714-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
CAS:Formula:C37H42F2N8O4Purezza:98%Colore e forma:SolidPeso molecolare:700.7774Posaconazole-d5
CAS:Formula:C37H37D5F2N8O4Colore e forma:White To Off-White SolidPeso molecolare:705.82Posaconazole
CAS:Formula:C37H42F2N8O4Purezza:98.0 - 102.0 % (dry basis)Colore e forma:White to off-white powderPeso molecolare:700.78Posaconazole
CAS:Posaconazole (POS) is a sterol C14ɑ demethylase inhibitor (IC50: 0.25 nM).Formula:C37H42F2N8O4Purezza:99.72% - >99.99%Colore e forma:White SolidPeso molecolare:700.78Ref: 4Z-P-38102
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaPosaconazole Impurity 92
CAS:Formula:C14H15F2N3O2Colore e forma:White To Off-White SolidPeso molecolare:295.29Ref: 4Z-P-38125
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaPosaconazole - Bio-X ™
CAS:Posaconazole is a triazole antifungal agent that inhibits the 14-alpha demethylase enzyme. This drug prevents the formation of fungal cell walls thus leading to fungal cell lysis. Posaconazole is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species in severely immunocompromised patients.Formula:C37H42F2N8O4Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:700.78 g/molPosaconazole - Form I
CAS:Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.Formula:C37H42F2N8O4Purezza:Min. 95%Peso molecolare:700.78 g/molPosaconazole
CAS:Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.
Formula:C37H42F2N8O4Purezza:Min. 98 Area-%Colore e forma:White PowderPeso molecolare:700.78 g/molPosaconazole - Form III
CAS:Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.
Formula:C37H42F2N8O4Purezza:Min. 95%Peso molecolare:700.78 g/molPosaconazole Monodesfluoro
CAS:Prodotto controllatoFormula:C21H22FN3O4SColore e forma:NeatPeso molecolare:431.481Posaconazole (Ethyl-d5)
CAS:Prodotto controllatoFormula:C37D5H37F2N8O4Colore e forma:NeatPeso molecolare:705.808
![4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0039KV.jpg&w=3840&q=75)
