CAS 171436-38-7

H-SER-LEU-ILE-GLY-ARG-LEU-NH2

Descrizione:

La sostanza chimica identificata come H-SER-LEU-ILE-GLY-ARG-LEU-NH2, con il numero CAS 171436-38-7, è un peptide composto da una sequenza specifica di amminoacidi: serina (Ser), leucina (Leu), isoleucina (Ile), glicina (Gly), arginina (Arg) e un'altra leucina (Leu). Questo peptide presenta una modifica all'estremità N-terminale (indicata da "H-") e un gruppo ammidico all'estremità C-terminale (indicata da "NH2"), che possono influenzare la sua stabilità e attività biologica. Peptidi come questo sono spesso studiati per i loro ruoli nei processi biologici, inclusi segnalazione, attività enzimatica e come potenziali agenti terapeutici. La presenza di amminoacidi idrofobici (Leu, Ile) e polari (Ser, Gly) suggerisce che il peptide possa avere interazioni diverse nei sistemi biologici. Inoltre, il residuo di arginina può contribuire alla carica positiva e a potenziali interazioni di legame con molecole caricate negativamente. In generale, le caratteristiche di questo peptide lo rendono un argomento di interesse in biochimica e farmacologia.

Formula: C₂₉H₅₆N₁₀O₇

Sinonimi:

• Ser-Leu-Ile-Gly-Arg-Leu-Amide
• Sligrlamide
• Sligrl-Nh2
• Thrombin Receptor-Like 1 (1-6) Amide (Mouse, Rat)
• Proteinase Activated Receptor 2 (1-6) Amide (Mouse, Rat)
• Proline/Betaine Transporter Fragment Amide
• Par-2 (1-6) Amide (Mouse, Rat)
• Par2-Ap

PAR-2 (1-6) amide (mouse, rat)

CAS: 171436-38-7

SLIGRL-amide, protease-activated receptor-2 (PAR2) selective agonist. The reverted PAR2 peptide can be used as inactive control.

Formula: C₂₉H₅₆N₁₀O₇

Purezza: 99.4%

Colore e forma: White

Peso molecolare: 656.83

Ref: 01-4033483

SLIGRL-NH2

CAS: 171436-38-7

SLIGRL-NH2

Purezza: ≥98%

Peso molecolare: 656.82g/mol

Ref: 54-BUP21798

SLIGRL-NH2

CAS: 171436-38-7

SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a PAR-2 agonist that induces non-histaminergic pruritus.

Formula: C₂₉H₅₆N₁₀O₇

Purezza: 98.29%

Colore e forma: Solid

Peso molecolare: 656.82

Ref: TM-TP1046

PAR-2 (1-6) (mouse, rat)

CAS: 171436-38-7

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₂₉H₅₆N₁₀O₇

Peso molecolare: 656.83 g/mol

Ref: 3D-PP50110

H-Ser-Leu-Ile-Gly-Arg-Leu-NH2

CAS: 171436-38-7

H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 is a cyclase inhibitor that binds to the neurokinin 1 receptor, leading to an inhibition of the release of inflammatory substances in the bowel. HSLIGRL can also inhibit epidermal growth factor (EGF), which suppresses inflammation and cell proliferation. HSLIGRL also inhibits inflammatory bowel disease by decreasing the production of prostaglandins, which are chemical messengers involved in pain and inflammation. HSLIGRL has been shown to be effective against low potency benzalkonium chloride, which is often used as a preservative in pharmaceuticals. This compound has been shown to reduce inflammation by inhibiting proinflammatory cytokines such as TNFα and IL1β.

Formula: C₂₉H₅₆N₁₀O₇

Purezza: Min. 95%

Peso molecolare: 656.83 g/mol

Ref: 3D-PAR-3664-PI

PAR-2 (1-6) amide (mouse, rat)

CAS: 171436-38-7

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₂₉H₅₆N₁₀O₇

Peso molecolare: 656.83 g/mol

Ref: 3D-PP50028

SLIGRL-NH2

CAS: 171436-38-7

Formula: C₂₉H₅₆N₁₀O₇

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 656.83

Ref: 10-F047237

SL-NH2 Trifluoroacetic Acid Salt (1:2)

Prodotto controllato

CAS: 171436-38-7

Applications SL-NH2 Trifluoroacetic Acid Salt (1:2), is a PAR2 acute agonist which causes hyperglasia, or an increase to the sensitivity to pain.
References Huang, Z. et al.; Brain Res., 1425, 20 (2011);

Formula: C₂₉H₅₆N₁₀O₇•2(C₂HF₃O₂)

Colore e forma: Neat

Peso molecolare: 656.82211402

Ref: TR-S560005

PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt

CAS: 171436-38-7

PAR-2 agonist is a synthetic peptide that activates PAR-2. It binds to PAR-2 receptors, which are present in the mesenteric vasculature and in various other tissues. Activation of PAR-2 leads to an increase in intracellular calcium concentration, activation of protein kinase C, cytosolic calcium ion release, phosphorylation of myosin light chain, muscle cell proliferation, transcription and translation initiation, and increased production of vasoactive intestinal peptide. This drug also has anti-inflammatory effects and stimulates epidermal growth factor (EGF) and thrombin receptor expression as well as growth factor production.

Formula: C₂₉H₅₆N₁₀O₇

Purezza: Min. 95%

Peso molecolare: 656.82 g/mol

Ref: 3D-FP109453