CAS 17321-77-6

cloridrato di clomipramina

Descrizione:

cloridrato di clomipramina è un antidepressivo triciclico utilizzato principalmente nel trattamento del disturbo ossessivo-compulsivo (DOC) e di altri disturbi dell'umore. Funziona inibendo il riassorbimento dei neurotrasmettitori, in particolare serotonina e norepinefrina, aumentando così la loro disponibilità nella fessura sinaptica. Questo composto appare come una polvere cristallina bianca o bianco sporco ed è solubile in acqua, rendendolo adatto per somministrazione orale. cloridrato di clomipramina ha una emivita relativamente lunga, il che consente una somministrazione una volta al giorno in molti casi. Il suo profilo farmacologico include una gamma di effetti collaterali, come sedazione, secchezza delle fauci e potenziali effetti cardiovascolari, richiedendo un attento monitoraggio nei pazienti. La sostanza è classificata come un farmaco da prescrizione ed è soggetta a controlli normativi a causa del suo potenziale per effetti collaterali e interazioni con altri farmaci. In generale, cloridrato di clomipramina è un importante agente terapeutico in psichiatria, particolarmente per i pazienti con DOC resistente al trattamento.

Formula: C₁₉H₂₄Cl₂N₂

InChI: InChI=1/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

InChI key: InChIKey=WIMWMKZEIBHDTH-UHFFFAOYSA-N

SMILES: C(CCN(C)C)N1C=2C(CCC=3C1=CC=CC3)=CC=C(Cl)C2.Cl

Sinonimi:

• 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine hydrochloride (1:1)
• 3-Chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride
• 3-Chloroimipramine hydrochloride
• 5H-Dibenz[b,f]azepine, 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-, monohydrochloride
• 5H-Dibenz[b,f]azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-, hydrochloride (1:1)
• 5H-Dibenz[b,f]azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-, monohydrochloride
• Anafranil
• Anaphranil
• Anatranil
• Chlorimipramine hydrochloride
• Chloroimipram-ine HCl
• Chloroimipramine monohydrochloride
• Clomipramine HCl
• ANAFRANIL HYDROCHLORIDE
• 5H-Dibenzb,fazepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-, monohydrochloride
• CLOMIPRAMINE HYDROCHLORIDE
• Clomipraminhydrochlorid
• 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine hydrochloride
• Chlomipramine
• 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5h-dibenz[b,f]azepine monohydrochloride
• 3-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5h-dibenz(b,f)azepinemono
• 3-CHLORO-10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZ[B,F]AZEPINE-5-PROPANAMINE HYDROCHLORIDE
• f)azepine,10,11-dihydro-3-chloro-5-(3-(dimethylamino)propyl)-5h-dibenz(mon
• f)azepine-5-propanamine,3-chloro-10,11-dihydro-n,n-dimethyl-5h-dibenz(mo
• CLOMIPRAMINE HYDROCHLORIDE \ SEROTONIN U PTAKE INHIBITOR, ANTIDEPRESSANT
• 3-chloroimipraminehydrochloride
• CHLOROIMIPRAMINE HYDROCHLORIDE

Clomipramine hydrochloride

Prodotto controllato

CAS: 17321-77-6

Clomipramine hydrochloride is the hydrochloride salt form of clomipramine, an amphiphilic drug, derivative of dibenzazepine. It is presumed that this tricyclic compound affects serotonin uptake in the brain increasing thus the activity of serotonin. Also, clomipramine reduces the re-uptake of norepinephrine (active metabolite desmethylclomipramine) and binds to alpha-adrenergic, histaminergic, and cholinergic receptors (side effects). Clomipramine is antidepressant, used to treat obsessive compulsive disorder, panic disorders and cataplexy. Clomipramine is shown to modulate immune activation, shows constant anti-inflammatory properties at therapeutic concentrations by consistently decreasing pro- inflammatory cytokines. Clomipramine could be a good candidate to counteract SARS-CoV-2 infection worsening thanks to its high penetration in the brain and its anti-inflammatory effects.

Formula: C₁₉H₂₄Cl₂N₂

Purezza: Min. 95%

Colore e forma: Solid

Peso molecolare: 351.31 g/mol

Ref: 3D-FC20505

Clomipramine hydrochloride - Bio-X ™

Prodotto controllato

CAS: 17321-77-6

Clomipramine is a tricyclic antidepressant drug that inhibits the reuptake of serotonin, norepinephrine, and dopamine. It is used to treat obsessive compulsive disorder, panic disorders and cataplexy. Additionally, Clomipramine is shown to modulate immune activation and shows constant anti-inflammatory properties at therapeutic concentrations by consistently decreasing pro-inflammatory cytokines.

Formula: C₁₉H₂₄Cl₂N₂

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 351.31 g/mol

Ref: 3D-BC164325