CAS 173334-57-1

Aliskiren

Descrizione:

Aliskiren è un composto farmaceutico classificato come inibitore diretto della renina, utilizzato principalmente nel trattamento dell'ipertensione. Il suo meccanismo d'azione implica l'inibizione della renina, un enzima che gioca un ruolo cruciale nel sistema renina-angiotensina-aldosterone (RAAS), che regola la pressione sanguigna e l'equilibrio dei fluidi. Aliskiren è caratterizzato dalla sua relativamente bassa solubilità in acqua, il che può influenzare la sua biodisponibilità e assorbimento. Il composto è tipicamente somministrato per via orale ed è noto per la sua lunga emivita, che consente una somministrazione una volta al giorno. Aliskiren è spesso utilizzato da solo o in combinazione con altri agenti antipertensivi per ottenere un migliore controllo della pressione sanguigna. Gli effetti collaterali comuni possono includere disturbi gastrointestinali, mal di testa e vertigini. Come per altri farmaci che influenzano il RAAS, si consiglia cautela nei pazienti con insufficienza renale o in gravidanza, poiché potrebbe comportare rischi per lo sviluppo fetale. In generale, Aliskiren rappresenta un approccio innovativo per gestire l'ipertensione mirando alle fasi iniziali della via del RAAS.

Formula: C₃₀H₅₃N₃O₆

InChI: InChI=1S/C30H53N3O6/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35)/t22-,23-,24-,25-/m0/s1

InChI key: InChIKey=UXOWGYHJODZGMF-QORCZRPOSA-N

SMILES: O(CCCOC)C1=C(OC)C=CC(C[C@@H](C[C@@H]([C@H](C[C@H](C(NCC(C(N)=O)(C)C)=O)C(C)C)O)N)C(C)C)=C1

Sinonimi:

• (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxo-propyl)-4-hydroxy-2-isopropyl-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-nonanamide hydrochloride
• (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(1-methylethyl)nonanamide
• (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(1-methylethyl)nonanamide (2E)-but-2-enedioate (salt)
• (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide
• (2S,4S,5S,7S)-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide
• (2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide
• (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide
• Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-
• Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, [αS-(αR*,γR*,δR*,ζR*)]-
• Cgp 60536
• Cgp60536B
• Enviage
• Rasilez
• Riprazo
• Spp 100
• Sprimeo
• Tekturna

5-Amino-n-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate

CAS: 173334-57-1

Formula: C₃₀H₅₃N₃O₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 551.7583

Ref: IN-DA001YTA

Aliskiren

CAS: 173334-57-1

Aliskiren

Purezza: ≥95%

Peso molecolare: 551.76g/mol

Ref: 54-BUP12969

Aliskiren

CAS: 173334-57-1

Formula: C₃₀H₅₃N₃O₆

Peso molecolare: 551.76

Ref: 7W-GP7354

Aliskiren

CAS: 173334-57-1

Aliskiren (CGP 60536) is a renin inhibitor (IC50: 1.5 nM) with antihypertensive activity and is used in the treatment of various cardiovascular diseases.

Formula: C₃₀H₅₃N₃O₆

Purezza: 97.02%

Colore e forma: Solid

Peso molecolare: 551.76

Ref: TM-T22233

5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumar ate

CAS: 173334-57-1

5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumar ate is a drug that inhibits the activity of angiotensin II, which is a hormone produced by the body. It is used as monotherapy for treatment of hypertension. 5AMINO has been shown to be effective in lowering blood pressure when administered alone and has been shown to be well tolerated. For this drug, the most frequently reported adverse reactions are nausea and dizziness. This drug should not be taken with other antihypertensive drugs or nonsteroidal antiinflammatory drugs such as ibuprofen (Motrin®). In addition, patients with diabetes should monitor their blood sugar levels carefully while taking this medication.

Formula: C₃₀H₅₃N₃O₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 551.76 g/mol

Ref: 3D-FA134549

ALISKIREN

CAS: 173334-57-1

Purezza: 98%

Peso molecolare: 551.7689819

Ref: 10-F793779