CAS 175413-77-1

Leech Osmoregulatory Factor

CAS: 175413-77-1

Leech Osmoregulatory Factor H-Ile-Pro-Glu-Pro-Tyr-Val-Trp-Asp-OH (LOF) is a polyunsaturated peptide that regulates osmotic pressure. It has been purified from the leech Hirudo medicinalis and can be used in diagnosis or treatment of eye disorders, such as diabetic neuropathy, or in the treatment of diseases associated with high blood viscosity. LOF binds to the surface of cells and induces changes in cell shape. The binding of LOF to receptors on the cell membrane triggers receptor binding and subsequent activation of ion channels. This leads to an increase in water permeability across the cell membrane and increases the glomerular filtration rate. LOF also binds to monoclonal antibodies that are specific for eye disorders or other conditions associated with high blood viscosity, which may be useful for diagnosis or treatment.

Formula: C₅₀H₆₇N₉O₁₄

Purezza: Min. 95%

Peso molecolare: 1,018.12 g/mol

Ref: 3D-FL109312