CAS 1775-97-9

Flavokawain B

Descrizione:

Flavokawain B è un composto naturale classificato come flavokawain, che è un tipo di chalcone. È principalmente derivato dalla specie vegetale *Kava* (Piper methysticum), nota per il suo uso tradizionale in varie culture per le sue proprietà psicoattive. La struttura chimica di Flavokawain B presenta uno scheletro di chalcone caratteristico, che consiste in due anelli aromatici collegati da un sistema carbonilico α,β-insaturo di tre carboni. Questo composto mostra una gamma di attività biologiche, comprese proprietà anti-infiammatorie, antiossidanti e potenziali proprietà anticancerogene, rendendolo un argomento di interesse nella ricerca farmacologica. Flavokawain B è anche noto per la sua capacità di modulare vari percorsi cellulari, il che può contribuire ai suoi effetti terapeutici. La sua solubilità e stabilità possono variare a seconda del solvente e delle condizioni ambientali, influenzando la sua biodisponibilità e efficacia nei sistemi biologici. Come molti composti naturali, sono necessari ulteriori studi per chiarire completamente i suoi meccanismi d'azione e le potenziali applicazioni in medicina.

Formula: C₁₇H₁₆O₄

InChI: InChI=1S/C17H16O4/c1-20-13-10-15(19)17(16(11-13)21-2)14(18)9-8-12-6-4-3-5-7-12/h3-11,19H,1-2H3/b9-8+

InChI key: InChIKey=QKQLSQLKXBHUSO-CMDGGOBGSA-N

SMILES: C(/C=C/C1=CC=CC=C1)(=O)C2=C(OC)C=C(OC)C=C2O

Sinonimi:

• (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one
• (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
• (E)-1-(2-Hydroxy-4,6-Dimethoxy-Phenyl)-3-Phenyl-Propenone
• (E)-1-(2-Hydroxy-4,6-dimethoxy-phenyl)-3-phenyl-
• (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
• (E)-2′-Hydroxy-4′,6′-dimethoxychalcone
• 1-(2-Hydroxy-4,6-Dimethoxyphenyl)-3-Phenyl-2-Propen-1-One)
• 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)-
• 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)-
• Cardamonin-4'-Methyl Ether
• Chalcone, 2′-hydroxy-4′,6′-dimethoxy-
• Dimethoxy-2'-Hydroxychalcone, 4',6'-
• Flavokavain B
• Flavokavin B
• Flavokawain B
• Flavokawin B

Flavokawain B

CAS: 1775-97-9

Flavokawain B analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₁₇H₁₆O₄

Purezza: (HPLC) ≥95%

Colore e forma: Powder

Peso molecolare: 284.31

Ref: 11-1045

2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)-

CAS: 1775-97-9

Formula: C₁₇H₁₆O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 284.3065

Ref: IN-DA0025DP

Flavokawain B

CAS: 1775-97-9

Formula: C₁₇H₁₆O₄

Peso molecolare: 284.31

Ref: 7W-GY4305

Flavokawain B

CAS: 1775-97-9

Flavokawain B

Purezza: ≥98%

Peso molecolare: 284.31g/mol

Ref: 54-BUP00989

Flavokawain B

CAS: 1775-97-9

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. Flavokawain B has potent anti-inflammatory, and anti-cancer activities, it can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

Formula: C₁₇H₁₆O₄

Purezza: 95%~99%

Colore e forma: Yellow powder

Peso molecolare: 284.311

Ref: BP-BP3146

Flavokawain B

CAS: 1775-97-9

Flavokawain B inhibits NO and PGE2, causes oxidative stress, and induces apoptosis, with potential for treating prostate cancer.

Formula: C₁₇H₁₆O₄

Purezza: 99.97% - >99.99%

Colore e forma: Solid

Peso molecolare: 284.31

Ref: TM-T6S0735

Flavokawain b

CAS: 1775-97-9

Ketone phenol

Formula: C₁₇H₁₆O₄

Purezza: ≥ 98.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 284.31

Ref: 5G-83763

Flavokavain B

Prodotto controllato

CAS: 1775-97-9

Applications Flavokavain B is a secondary metabolite of the kava plant (Piper methysticum Forst. f., Piperaceae, which has anticancer properties and demonstrated oral efficacy in murine cancer models.  Futhermore, it also has suspected roles in rare cases of kava-induced hepatotoxicity. In addition, it is a potential candidate for the development of novel antifungal phytotherapic products.
References Pinner, K. D., et al.: Pharmaceutical Biology (Abingdon, United Kingdom), 54, Epub ahead of print (2016); Rowe A., et al.: Phytotherapy Research, 26, 1768 (2012); Alves dos Santos, R., et al.: Journal of Chemistry, (2013)

Formula: C₁₇H₁₆O₄

Colore e forma: Yellow To Dark Yellow

Peso molecolare: 284.31

Ref: TR-F371025

4',6'-Dimethoxy-2'-hydroxychalcone

CAS: 1775-97-9

4',6'-Dimethoxy-2'-hydroxychalcone is a chalcone compound, which is a type of flavonoid. Flavonoids are polyphenolic compounds synthesized by plants. This particular compound is typically derived from various plant sources, where it plays a role in the plant's defense mechanisms. As a chalcone, it contains a characteristic open-chain framework that distinguishes it from other flavonoids.

Formula: C₁₇H₁₆O₄

Purezza: Min. 95%

Peso molecolare: 284.31 g/mol

Ref: 3D-FD66669