CAS 177582-21-7

Fmoc-Cys(Mmt)-OH

Descrizione:

Fmoc-Cys(Mmt)-OH, noto anche come cisteina protetta da Fmoc con un gruppo protettivo metossitriptil (Mmt), è un composto chimico comunemente utilizzato nella sintesi di peptidi. Presenta un gruppo fenilmetossicarbonile (Fmoc), che funge da gruppo protettivo per il gruppo amminico della cisteina, consentendo reazioni selettive durante l'assemblaggio dei peptidi. Il gruppo Mmt protegge la catena laterale tiol della cisteina, prevenendo reazioni indesiderate mentre facilita la sintesi di peptidi che contengono questo amminoacido. Questo composto è tipicamente utilizzato nella sintesi di peptidi in fase solida (SPPS) grazie alla sua stabilità e compatibilità con vari reagenti di accoppiamento. Fmoc-Cys(Mmt)-OH è caratterizzato dalla sua capacità di subire disprotezione in condizioni acide leggere, rilasciando il residuo di cisteina libera per ulteriori reazioni. La presenza dei gruppi Fmoc e Mmt consente un maggiore controllo sul processo di sintesi, rendendolo un intermedio prezioso nella produzione di peptidi e proteine per applicazioni di ricerca e terapeutiche. Il suo numero CAS, 177582-21-7, è un identificatore unico che aiuta nella catalogazione e nel recupero di informazioni relative a questo specifico composto.

Formula: C₃₈H₃₃NO₅S

InChI: InChI=1/C38H33NO5S/c1-43-29-22-20-28(21-23-29)38(26-12-4-2-5-13-26,27-14-6-3-7-15-27)45-25-35(36(40)41)39-37(42)44-24-34-32-18-10-8-16-30(32)31-17-9-11-19-33(31)34/h2-23,34-35H,24-25H2,1H3,(H,39,42)(H,40,41)/t35-/m0/s1

SMILES: COc1ccc(cc1)C(c1ccccc1)(c1ccccc1)SC[C@@H](C(=O)O)N=C(O)OCC1c2ccccc2c2ccccc12

Sinonimi:

• N-alpha-(9-fluorenylmethyloxycarbonyl)-S-p-methoxytrityl-L-cysteine
• (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(4-methoxyphenyl)-diphenyl-methyl]sulfanyl-propanoic acid
• N-ALPHA-FMOC-S-4-METHOXYTRITYL-L-CYSTEINE
• Fmoc-Cys(MMT)-OH(non-animal)
• Fmoc-Cys(4-methoxytrityl)-OH >=98% (HPLC)
• (9H-Fluoren-9-yl)MethOxy]Carbonyl Cys(MMt)-OH
• Fmoc-S-4-methoxytrityl-L-cysteine≥ 99.8% (HPLC, Chiral purity)
• Fmoc-Cys(Mmt)-OH Novabiochem
• (R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-((4-methoxyphenyl)diphenylmethylthio)propanoic acid
• L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-[(4-methoxyphenyl)diphenylmethyl]-
• (R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[(4-methoxyphenyl)diphenylmethylsulfanyl]propionic acid
• FMOC-CYS(MMT)-OH USP/EP/BP
• (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-{[(4-methoxyphenyl)diphenylmethyl]sulfanyl}propanoic acid
• FMOC-L-CYS(MMT)-OH
• FMOC-S-4-METHOXYTRITYL-L-CYSTEINE
• FMOC-CYS(MEOTRT)-OH
• FMOC-S-P-METHOXYTRITYL-L-CYSTEINE
• N-ALPHA-FMOC-S-P-METHOXYTRITYL-L-CYSTEINE
• Nα-(9-Fluorenylmethyloxycarbonyl)-S-4-methoxytrityl-L-cysteine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[(4-methoxyphenyl)diphenylmethyl]-L-cysteine
• N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-S-P-METHOXYTRITYL-L-CYSTEINE
• NALPHA-9-Fluorenylmethoxycarbonyl-S-(4-methoxytriphenylmethyl)-L-cysteine
• FMoc-Cys(MMt)-OH FMoc-S-p-Methoxytrityl-L-cysteine

Fmoc-Cys(4-methoxytrityl)-OH

CAS: 177582-21-7

4-Methoxytrityl (Mmt) is a very acid-sensitive cysteine protecting group that can selectively be removed by 0.5-1.0% TFA in the presence of scavengers, e.g. TES. Protecting groups of the t-butyl type and S-Trt are left intact under these conditions. Cleavage and cyclization can be achieved concomitantly by adding iodine. It can be used in the solid-phase synthesis of cysteine-containing peptides, and further to selectively deprotect a thiol function in order to introduce a labeling group. Rijkers et al. employed p-methoxytrityl protection for obtaining S-palmitoylated peptides on-resin. The high acid lability of Cys(Mmt) was exploited by Roberts et al. to obtain a library of thioether-linked cyclic peptides. Arendt et al. employed Cys(Mmt) for the synthesis of peptides containing cysteic acid by selective deblocking and oxidation of the thiol moiety with performic acid. Mmt is fully stable to HOBt.

Formula: C₃₈H₃₃NO₅S

Purezza: 99.1%

Colore e forma: White

Peso molecolare: 615.76

Ref: 01-4025726

Fmoc-Cys(4-methoxytrityl)-OH

CAS: 177582-21-7

Formula: C₃₈H₃₃NO₅S

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 615.7373

Ref: IN-DA003QMX

N-[(9H-Fluoren-9-Yl Methoxy)Carbonyl]-S-[(4-Methoxyphenyl)Diphenylmethyl]-L-Cysteine

CAS: 177582-21-7

N-[(9H-Fluoren-9-Yl Methoxy)Carbonyl]-S-[(4-Methoxyphenyl)Diphenylmethyl]-L-Cysteine

Purezza: 98%

Peso molecolare: 615.74g/mol

Ref: 54-OR1029757

Fmoc-Cys(4-methoxytrityl)-OH

CAS: 177582-21-7

Formula: C₃₈H₃₃NO₅S

Purezza: (HPLC) ≥ 98.0%

Colore e forma: White powder

Peso molecolare: 615.7

Ref: 7W-GM0099

Fmoc-S-4-methoxytrityl-L-cysteine

CAS: 177582-21-7

Fmoc-S-4-methoxytrityl-L-cysteine is a synthetic, amphipathic, amide, ester linkages, cyclic peptide. It has been shown to be a potent growth factor that inhibits the proliferation of human pancreatic cancer cells in tissue culture and induces apoptosis in these cells. Fmoc-S-4-methoxytrityl-L-cysteine also inhibits the growth of staphylococcus in tissue culture and reduces metastatic pancreatic cancer cell proliferation in rats.

Formula: C₃₈H₃₃NO₅S

Purezza: 90%Min

Colore e forma: White Powder

Peso molecolare: 615.74 g/mol

Ref: 3D-FF47756

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[(4-methoxyphenyl)diphenylmethyl]-L-cysteine

CAS: 177582-21-7

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 615.7399902

Ref: 10-F601172