CAS 1781828-85-0

Ro 32-0432 Hydrochloride

Prodotto controllato

CAS: 1781828-85-0

Formula: C₂₈H₂₈N₄O₂·ClH

Colore e forma: Neat

Peso molecolare: 489.009

Ref: TR-R700970

Ro 32-0432 hydrochloride

CAS: 1781828-85-0

Ro 32-0432 hydrochloride is a small molecule that binds to β-catenin, a transcription factor required for the formation of protrusions, and inactivates it. This drug is currently being studied as an inhibitor of cancer metastasis. Ro 32-0432 hydrochloride has been shown to inhibit cell adhesion and migration in organoids derived from human lung cancer cells. It also blocks the activation of the Wnt/β-catenin signaling pathway in breast cancer cells by targeting β-catenin. The mechanism of action of Ro 32-0432 hydrochloride is not yet fully understood.

Formula: C₂₈H₂₉ClN₄O₂

Purezza: Min. 95%

Peso molecolare: 489 g/mol

Ref: 3D-GWC82885

(S)-Ro 32-0432

CAS: 1781828-85-0

(S)-Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S)-Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].

Formula: C₂₈H₂₉ClN₄O₂

Colore e forma: Solid

Peso molecolare: 489.01

Ref: TM-T84742