CAS 179463-17-3

Cancidas

Descrizione:

Cancidas, con il numero CAS 179463-17-3, è il nome commerciale dell'agente antifungino caspofungina. Appartiene alla classe degli antifungini chiamati echinocandine, noti per il loro meccanismo d'azione che inibisce la sintesi di β-(1,3)-D-glucano, un componente essenziale della parete cellulare fungina. Questa interruzione porta alla lisi cellulare e alla morte del fungo. La caspofungina è utilizzata principalmente per trattare infezioni fungine invasive, in particolare quelle causate da specie di Candida e Aspergillus, specialmente in pazienti immunocompromessi. Viene somministrata per via endovenosa ed è caratterizzata da un profilo di tossicità relativamente basso rispetto ad altri agenti antifungini. Il farmaco è generalmente ben tollerato, con effetti collaterali che possono includere febbre, eruzione cutanea e disturbi gastrointestinali. La sua farmacocinetica prevede una lenta emivita di eliminazione, consentendo una somministrazione una volta al giorno. In generale, Cancidas rappresenta un'opzione critica nella gestione di infezioni fungine gravi, in particolare in pazienti resistenti ad altre terapie antifungine.

Formula: C₅₆H₉₆N₁₀O₁₉

InChI: InChI=1/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);2*1H3,(H,3,4)/t28?,29?,30-,33-,34-,35+,36-,37+,38-,40+,41+,42+,43?,44+,45+,46+;;/m1../s1

Sinonimi:

• Caspofungin acetate
• (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate
• N-{(2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide
• N-{(2R,6S,9S,11R,12R,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1S)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide acetate (1:2)
• N-{(2R,6S,9R,11R,12S,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide acetate (1:2)
• Cancidas (Caspofungin Acetate)

Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2)

CAS: 179463-17-3

Formula: C₅₄H₉₂N₁₀O₁₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1153.3651

Ref: IN-DA002711

Caspofungin Diacetate

CAS: 179463-17-3

Formula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Colore e forma: White To Off-White Solid

Peso molecolare: 1093.34 2*60.05

Ref: 4Z-PC-155001

Caspofungin Acetate

CAS: 179463-17-3

Caspofungin Acetate

Purezza: ≥95%

Peso molecolare: 1213.42g/mol

Ref: 54-BUP06070

Caspofungin acetate

CAS: 179463-17-3

Formula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Purezza: (HPLC) ≥ 97.0% (anhydrous basis)

Colore e forma: White to off-white powder

Peso molecolare: 1213.42

Ref: 7W-GP8659

Caspofungin Acetate

CAS: 179463-17-3

Caspofungin Acetate (MK 0991) is the acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the

Formula: C₅₆H₉₆N₁₀O₁₉

Purezza: 97.94% - 99.9%

Colore e forma: White Powder

Peso molecolare: 1213.42

Ref: TM-T1799

Caspofungin Acetate

CAS: 179463-17-3

Applications An echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.
References Sandhu, P. et al.: Antimicrob. Agents Chemorther., 48, 1272 (2004); Bertsche, T. et al.: Pharamaz. Zeit., 148, 34 (2003); Hoang, A.: Am. J. Health-Sys. Pharm., 58, 1206 (2001);

Formula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Purezza: >90%

Colore e forma: White To Light Yellow

Peso molecolare: 1213.42

Ref: TR-C184900

Caspofungin acetate

Prodotto controllato

CAS: 179463-17-3

Inhibitor of glucan synthase; antifungal compound

Formula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Purezza: Min. 90 Area-%

Colore e forma: Powder

Peso molecolare: 1,213.42 g/mol

Ref: 3D-FC16269

Caspofungin acetate - Bio-X ™

Prodotto controllato

CAS: 179463-17-3

Caspofungin is an echinocandin that belongs to the class of antifungal agents. It is used to treat Aspergillus and Candida infections. It works by inhibiting the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species.

Formula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 1,213.42 g/mol

Ref: 3D-BC164293