CAS 1799633-27-4

acido (αR)-α-[[(5S)-5-[3-cloro-2-metil-4-[2-(4-metil-1-piperazinil)etossi]fenil]-6-(5-fluoro-2-furanil)tieno[2,3-d]pirimidin-4-il]ossi]-2-[[1-(2,2,2-trifluoroetil)-1H-pirazol-5-il]metossi]benzenpropanoico

Descrizione:

La sostanza chimica con il nome "(αR)-α-[[[5S)-5-[3-Cloro-2-metil-4-[2-(4-metil-1-piperazinil)etossifenile]-6-(5-fluoro-2-furano)tieno[2,3-d]pirimidina-4-ile]ossido]-2-[[1-(2,2,2-trifluoroetile)-1H-pirazolo-5-ile]metossibenzene-propanoico" e numero CAS "1799633-27-4" è un composto organico complesso caratterizzato dalla sua struttura multifunzionale, che include vari eterocicli e gruppi funzionali. Questo composto presenta un nucleo di tieno[2,3-d]pirimidina, noto per la sua attività biologica, in particolare in chimica medicinale. La presenza di un gruppo cloro, di un moiety trifluoroetilico e di un anello di piperazina suggerisce potenziali interazioni con bersagli biologici, rendendolo di interesse nella ricerca farmaceutica. Inoltre, la struttura del composto indica che potrebbe mostrare lipofilia a causa della presenza di anelli aromatici e sostituenti alchili, che possono influenzare la sua solubilità e permeabilità. In generale, questa sostanza è probabile che venga studiata per le sue proprietà farmacologiche, comprese potenziali attività anti-infiammatorie o anticancro, sebbene siano necessari dati biologici specifici per confermare la sua efficacia e il profilo di sicurezza.

Formula: C₃₉H₃₇ClF₄N₆O₆S

InChI: InChI=1S/C39H37ClF4N6O6S/c1-23-26(7-8-28(34(23)40)53-18-17-49-15-13-48(2)14-16-49)32-33-36(45-22-46-37(33)57-35(32)29-9-10-31(41)55-29)56-30(38(51)52)19-24-5-3-4-6-27(24)54-20-25-11-12-47-50(25)21-39(42,43)44/h3-12,22,30H,13-21H2,1-2H3,(H,51,52)

InChI key: InChIKey=ZFBHXVOCZBPADE-UHFFFAOYSA-N

SMILES: O(C(CC1=C(OCC=2N(CC(F)(F)F)N=CC2)C=CC=C1)C(O)=O)C3=C4C(=C(SC4=NC=N3)C5=CC=C(F)O5)C6=C(C)C(Cl)=C(OCCN7CCN(C)CC7)C=C6

Sinonimi:

• Benzenepropanoic acid, α-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]-, (αR)-
• S 63845
• (αR)-α-[[(5S)-5-[3-Chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]benzenepropanoic acid
• S-63845

Benzenepropanoic acid, α-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]-, (αR)-

CAS: 1799633-27-4

Formula: C₃₉H₃₇ClF₄N₆O₆S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 829.2593

Ref: IN-DA0021IR

S63845

CAS: 1799633-27-4

S63845

Purezza: ≥95%

Peso molecolare: 829.26g/mol

Ref: 54-BUP01542

S63845

CAS: 1799633-27-4

S63845

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 829.26g/mol

Ref: 54-BISN0043

S63845

CAS: 1799633-27-4

S63845 is a selective myeloid leukemia 1（MCL1) inhibitor that binds to human MCL1 with a Kd of 0.19 nM.Cost-effective and quality-assured.

Formula: C₃₉H₃₇ClF₄N₆O₆S

Purezza: 97.7% - ≥98%

Colore e forma: Solid

Peso molecolare: 829.26

Ref: TM-T5346

S 63845

CAS: 1799633-27-4

S 63845 is a novel anti-cancer drug that belongs to the class of ubiquitin ligases. It has been shown to induce apoptosis in cancer cells and inhibit tumor growth in vivo. S 63845 also inhibits the phosphorylation of cyclin D2, which may be a potential biomarker for sclerosing cholangitis (SCC). This compound is highly cytotoxic and has been found to be effective against subcutaneous tumors in mice. S 63845 also inhibits the proliferation of primary cells and has been shown to significantly reduce hepatic steatosis, as well as inhibiting inflammation caused by toll-like receptor 4 activation.

Formula: C₃₉H₃₇ClF₄N₆O₆S

Purezza: Min. 95%

Colore e forma: Solid

Peso molecolare: 829.26 g/mol

Ref: 3D-BS166833