CAS 180637-89-2

3-[(2R)-1-Metil-2-pirrolidinil]metil-5-[2-(fenilsulfonil)etenil]-1H-indolo

Descrizione:

3-[(2R)-1-Metil-2-pirrolidinil]metil-5-[2-(fenilsulfonil)etenil]-1H-indolo, con il numero CAS 180637-89-2, è un composto organico sintetico caratterizzato dalla sua struttura complessa, che include un nucleo di indolo, un moiety di pirrolidina e un gruppo fenilsulfonile. Questo composto presenta un centro chirale, contribuendo alla sua stereochimica, che può influenzare la sua attività biologica e interazioni. La presenza dell'anello di indolo suggerisce potenziali applicazioni in chimica medicinale, poiché gli indoli si trovano spesso in composti biologicamente attivi. Il gruppo fenilsulfonile può migliorare la solubilità e la stabilità, mentre il componente di pirrolidina può influenzare la farmacocinetica del composto. In generale, questa sostanza è di interesse in contesti di ricerca, in particolare nello sviluppo di farmaci, a causa delle sue caratteristiche strutturali uniche che possono conferire proprietà biologiche specifiche. Ulteriori studi sarebbero necessari per chiarire i suoi esatti meccanismi d'azione e potenziali applicazioni terapeutiche.

Formula: C₂₂H₂₄N₂O₂S

InChI: InChI=1S/C22H24N2O2S/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20/h2-4,7-11,13-14,16,19,23H,5-6,12,15H2,1H3/t19-/m1/s1

InChI key: InChIKey=MJICWWOZPCLNBP-LJQANCHMSA-N

SMILES: C(C=1C=2C(NC1)=CC=C(C=CS(=O)(=O)C3=CC=CC=C3)C2)[C@@H]4N(C)CCC4

Sinonimi:

• (R)-3-((1-Methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indole
• 1H-Indole, 3-[(1-methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethenyl]-, (R)-
• 1H-Indole, 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethenyl]-
• 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethenyl]-1H-indole
• 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5-[(E)-2-(phenylsulfonyl)ethenyl]-1H-indole

(R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

CAS: 180637-89-2

Formula: C₂₂H₂₄N₂O₂S

Peso molecolare: 380.5032

Ref: IN-DA002279

(R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

Prodotto controllato

CAS: 180637-89-2

Applications (R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole is the free base of (R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole Hydrobromide (B120725), which is an impurity of Eletriptan (E505000). Eletriptan is a selective serotonin 5-HT1B and 5-HT1D receptor agonist and used to treat migraines (1,2,3). (R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole is also an intermediate in the synthesis of 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-1-[1-[3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-indol-5-yl]-2-(phenylsulfonyl)ethyl]-5-[(1E)-2-(phenylsulfonyl)ethenyl]-1H-indole (M320195).
References Madasu, S. B., et al.: Beilstein. J. Org. Chem., 8, 1400 (2012); Willems, E., et al.: Arch. Pharmacol., 358, 212 (1998); Napier, C., et al.: Eur. J. Pharmacol., 368, 259 (1999); Goadsby, P.J., et al.: Neurology, 54, 156 (2000)

Formula: C₂₂H₂₄N₂O₂S

Colore e forma: Neat

Peso molecolare: 380.5

Ref: TR-B120728

R-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

CAS: 180637-89-2

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Formula: C₂₂H₂₄N₂O₂S

Purezza: Min. 95%

Peso molecolare: 380.5 g/mol

Ref: 3D-FB18184

Dehydro Eletriptan

CAS: 180637-89-2

Formula: C₂₂H₂₄N₂O₂S

Peso molecolare: 380.5

Ref: ST-EA-CP-E11019