CAS 181183-52-8
:Almotriptan malato
Descrizione:
Almotriptan malato è un composto farmaceutico utilizzato principalmente nel trattamento dell'emicrania. Appartiene alla classe dei farmaci triptani, progettati specificamente per alleviare i sintomi dell'emicrania agendo come agonisti sui recettori della serotonina, in particolare sui sottotipi 5-HT_1B e 5-HT_1D. Questa azione porta alla vasocostrizione dei vasi sanguigni cranici e all'inibizione del rilascio di neuropeptidi pro-infiammatori. L'almotriptano è caratterizzato dalla sua relativamente alta biodisponibilità orale e da un profilo farmacocinetico favorevole, che include una emivita moderata che consente una gestione efficace degli attacchi acuti di emicrania. La forma di sale di malato ne migliora la solubilità e stabilità, facilitando l'assorbimento nel tratto gastrointestinale. L'almotriptano è generalmente ben tollerato, anche se può causare effetti collaterali come vertigini, affaticamento o sensazioni di formicolio. Come altri triptani, è controindicato in pazienti con determinate condizioni cardiovascolari a causa del potenziale di vasocostrizione. In generale, Almotriptan malato rappresenta un'opzione importante nell'arsenale terapeutico per la gestione dell'emicrania.
Formula:C17H25N3O2S·C4H6O5
InChI:InChI=1/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)
InChI key:InChIKey=QHATUKWEVNMHRY-UHFFFAOYSA-N
SMILES:C(CN(C)C)C=1C=2C(NC1)=CC=C(CS(=O)(=O)N3CCCC3)C2.C(CC(O)=O)(C(O)=O)O
Sinonimi:- 1-[[3-(2-Dimethylaminoethyl)-5-Indolyl]Methanesulphonyl]Pyrrolidine Malate
- 1-[[[2-(Dimethyl-Amino)Ethyl]-1H-Indol-5-Yl]Methyl]Sulfonyl]Pyrrolidine Malate
- 2-hydroxybutanedioic acid - N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1)
- Almotrip forte
- Almotriptan Malate
- Almotriptan Maleate
- Almotriptanmaleate
- Axert
- Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
- Butanedioic acid, hydroxy-, compd with 1-[[[3-[2-(dimethylamino)ethyl]-1h-indol-5-yl]methyl]sulfonyl]pyrrolidine
- Butanedioic acid, hydroxy-, compd. with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine (1:1)
- LAS 31416 <span class="text-smallcaps">D</smallcap>,<smallcap>L</span>-malate acid
- Las-31416 Malate
- N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine
- Pnu 180638
- Pnu 180638E
- Pyrrolidine, 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]-, hydroxybutanedioate (1:1)
- LAS 31416 D,L-malate acid
- hydroxy-Butanedioic acid, compd.with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine(1:1)(9CI)
- N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine,compd. with 2-hydroxy-butanedioic acid
- Almotriptan
- AlMotriptan Malate (Axert)
- Amotriptan malate
- 1-[[[3-[2-(dimeth
- See: A575201
- 2-Hydroxy-butanedioic acid, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
- Almotriptan Malate (200 mg)
- Vedi altri sinonimi
Ordinare per
Purezza (%)
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13 prodotti.
Ref: ST-EA-CP-A53037
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaAlmotriptan Malate
CAS:Sulfonamides used as drugsFormula:C17H25N3O2S·C4H6O5Colore e forma:White Off-White Crystalline PowderPeso molecolare:335.16675Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
CAS:Formula:C21H31N3O7SPurezza:98%Colore e forma:SolidPeso molecolare:469.5517Almotriptan-d6 Malate
CAS:Formula:C17H19D6N3O2S·C4H6O5Colore e forma:White To Off-White SolidPeso molecolare:341.50 134.09Almotriptan Malate
CAS:Formula:C17H25N3O2S·C4H6O5Colore e forma:Pale Yellow SolidPeso molecolare:335.47 134.09Almotriptan Malate
CAS:Formula:C17H25N3O2S·C4H6O5Purezza:>98.0%(HPLC)Colore e forma:White to Orange to Green powder to crystalPeso molecolare:469.55Almotriptan Malate
CAS:<p>Almotriptan Malate (PNU180638), a selective 5-HT1B/1D receptor agonist, is used in the therapy of Migraine attacks in adults.</p>Formula:C17H25N3O2S·C4H6O5Purezza:99.95%Colore e forma:Pale Yellow SolidPeso molecolare:469.55Almotriptan malate
CAS:<p>Almotriptan malate is a serotonin 1B/1D receptor agonist that is used as an anti-migraine drug, specifically for the treatment of migraine headaches with or without aura. It has been shown to cause regression of angiogenic factors and statistically significant improvement in migraine headache frequency, severity, and duration when taken within 24 hours of onset of a migraine. Almotriptan malate can be administered by nasal spray or oral tablets. The recommended dose for adults is 25-50 mg (1-2 tablets) taken at the first sign of a headache. Almotriptan malate should not be given to people who have liver impairment or are taking sodium carbonate. Side effects may include nasal congestion, dizziness, dry mouth, nausea, vomiting, and diarrhea. Almotriptan malate should be used with caution in patients with hypertension. Almotriptan malate is contraindicated in patients who have had a stroke or transient ischemic</p>Formula:C17H25N3O2S•C4H6O5Purezza:Min. 95%Colore e forma:SolidPeso molecolare:469.55 g/molAlmotriptan Malate
CAS:<p>Applications Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.<br>References Fleishaker, J.C., et al.: Clin. Pharmacol. Ther., 67, 498 (2000), Kamali, F., et al.: Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs, 2, 197 (2000), Dodick, D.W., et al.: Expert Opin.Pharmacother., 4, 1157 (2003)<br></p>Formula:C17H25N3O2S·C4H6O5Colore e forma:NeatPeso molecolare:469.55
![Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indol…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0022QH.jpg&w=3840&q=75)
