CAS 18323-44-9

Clindamicina

Descrizione:

Clindamicina è un antibiotico lincosamide che viene utilizzato principalmente per trattare varie infezioni batteriche, in particolare quelle causate da batteri anaerobi e alcuni protozoi. È efficace contro i batteri Gram-positivi, comprese alcune ceppi di Staphylococcus e Streptococcus. Clindamicina agisce inibendo la sintesi proteica batterica, impedendo così la crescita e la riproduzione dei batteri. La formula chimica di Clindamicina è C18H33ClN2O5S, e ha un peso molecolare di circa 406,99 g/mol. Viene tipicamente somministrato per via orale o endovenosa ed è disponibile in varie formulazioni, comprese capsule, soluzioni topiche e forme iniettabili. Clindamicina è noto per la sua buona penetrazione nei tessuti, rendendolo particolarmente utile nel trattamento delle infezioni della pelle e dei tessuti molli. Tuttavia, può anche portare a effetti collaterali, come disturbi gastrointestinali e, in rari casi, diarrea associata a Clostridium difficile. A causa del suo meccanismo d'azione e dello spettro di attività, Clindamicina è spesso utilizzato come alternativa per i pazienti allergici alla penicillina.

Formula: C₁₈H₃₃ClN₂O₅S

InChI: InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9-,10+,11-,12+,13-,14+,15+,16+,18+/m0/s1

InChI key: InChIKey=KDLRVYVGXIQJDK-AWPVFWJPSA-N

SMILES: [C@@H](NC(=O)[C@@H]1C[C@@H](CCC)CN1C)([C@H](C)Cl)[C@]2(O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[H]

Sinonimi:

• (2S,4R)-N-[2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl]propyl]-1-methyl-4-propyl-pyrrolidine-2-carboxamide
• 7(S)-Chloro-7-deoxylincomycin
• 7-Cdl
• 7-Chloro-7-deoxylincomycin
• 7-Chlorolincomycin
• 7-Deoxy-7(S)-chlorolincomycin
• <span class="text-smallcaps">L</smallcap>-threo-<smallcap>D</smallcap>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-<smallcap>L</span>-2-pyrrolidinecarboxamido)-1-thio-, trans- α-
• <span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)-
• <span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-
• Antirobe
• Chlolincocin
• Cleocin
• Clincin
• ClindaDerm
• Clindam
• Clindamicina
• Clindamycine
• Clinimycin
• Dalacin C
• Dalacin V
• Dalacine
• Klimicin
• Klindan 300
• L-threo-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, trans- α-
• L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)-
• L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-
• Methyl (7xi)-7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-glycero-alpha-D-galacto-octopyranoside
• Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-<span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-octopyranoside
• Sobelin
• U 21251
• methyl (5xi)-7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-L-glycero-alpha-D-galacto-octopyranoside hydrochloride
• methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-L-threo-alpha-D-galacto-octopyranoside
• methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-beta-L-arabino-octopyranoside hydrochloride
• Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside

Clindamycin Hydrochloride Monohydrate

CAS: 18323-44-9, 21462-39-5, 58207-19-5

Formula: C₁₈H₃₃ClN₂O₅S·HCl·H₂O

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 479.46

Ref: 3B-C2256

Clindamycin (Clindamycin Phosphate EP Impurity E)

CAS: 18323-44-9

Formula: C₁₈H₃₃ClN₂O₅S

Peso molecolare: 424.98

Ref: 4Z-C-5039

Clindamycin

CAS: 18323-44-9

Clindamycin

Purezza: ≥98%

Peso molecolare: 424.98g/mol

Ref: 54-BUP13892

Clindamycin

CAS: 18323-44-9

Clindamycin is a semisynthetic antibiotic that blocks bacterial protein synthesis by detaching peptidyl-tRNA from ribosomes.

Formula: C₁₈H₃₃ClN₂O₅S

Purezza: 98.04% - 99.87%

Colore e forma: Yellow Amorphous Solid Solid

Peso molecolare: 424.98

Ref: TM-T6447

Clindamycin Pyrophosphate Triethylamine Salt

Prodotto controllato

CAS: 18323-44-9

Stability Hygroscopic
Applications Clindamycin Pyrophosphate is an impurity of Clindamycin (C580000, HCl salt) which is a semi-synthetic antibiotic prepared from Lincomycin.
References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970), Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970), Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972), Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981),

Formula: C₁₈H₃₅ClN₂O₁₁P₂SxC₆H₁₅N

Colore e forma: Neat

Peso molecolare: 584.94

Ref: TR-C580090

Clindamycin

CAS: 18323-44-9

Applications Clindamycin is a semi-synthetic antibiotic. Antibacterial.
References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981);

Formula: C₁₈H₃₃ClN₂O₅S

Colore e forma: Neat

Peso molecolare: 424.98

Ref: TR-C580115

Clindamycin

CAS: 18323-44-9

Inhibitor of protein synthesis; lincosamide class

Formula: C₁₈H₃₃ClN₂O₅S

Purezza: Min. 95%

Peso molecolare: 424.98 g/mol

Ref: 3D-AC34039

Clindamycin Phosphate EP Impurity E

CAS: 18323-44-9

Formula: C₁₈H₃₃ClN₂O₅S

Peso molecolare: 424.98

Ref: ST-EA-CP-C26005