CAS 183319-69-9

Cloridrato di erlotinib

Descrizione:

Cloridrato di erlotinib è un inibitore della tirosina chinasi a piccole molecole utilizzato principalmente nel trattamento del carcinoma polmonare non a piccole cellule e del carcinoma pancreatico. Mira specificamente al recettore del fattore di crescita epidermico (EGFR), inibendo la sua attività e bloccando così le vie di segnalazione che promuovono la crescita e la sopravvivenza del tumore. Il composto è tipicamente somministrato per via orale ed è noto per la sua capacità di penetrare la barriera emato-encefalica, rendendolo efficace per alcune metastasi cerebrali. Cloridrato di erlotinib è caratterizzato dalla sua solubilità in acqua grazie alla presenza del sale cloridrato, che ne migliora la biodisponibilità. La formula molecolare riflette la sua struttura complessa, che include un nucleo di chinazolina. Gli effetti collaterali comuni associati al suo uso includono eruzione cutanea, diarrea e possibile elevazione degli enzimi epatici. Come molte terapie mirate, l'efficacia dell'erlotinib può essere influenzata dalla presenza di mutazioni specifiche nel gene EGFR, rendendo il test genetico una considerazione importante nella pianificazione del trattamento. In generale, Cloridrato di erlotinib rappresenta un significativo progresso nella terapia personalizzata contro il cancro.

Formula: C₂₂H₂₄ClN₃O₄

InChI: InChI=1/C22H23N3O4.ClH/c1-4-16-5-7-17(8-6-16)25-22-18-13-20(28-11-9-26-2)21(29-12-10-27-3)14-19(18)23-15-24-22;/h1,5-8,13-15H,9-12H2,2-3H3,(H,23,24,25);1H

InChI key: InChIKey=GTTBEUCJPZQMDZ-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=C(OCCOC)C(OCCOC)=C2)N=CN1)C3=CC(C#C)=CC=C3.Cl

Sinonimi:

• 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1)
• 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, monohydrochloride
• 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride
• Cp 358774
• Erlotinib HCl
• Erlotinib Hcl Salt
• Erlotinib, Hydrochloride Salt
• Erlotinib, OS-774
• N-(2-chloro-6-methyl-phenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methyl-pyrimidin-4-yl]amino]thiazole-5-carboxamide
• N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4- Hydrochloride
• N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine Hydrochloride
• N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride
• N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
• N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride (1:1)
• N-(4-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride (1:1)
• Osi 774
• Tarceva
• [6,7-Bis(2-methoxyethoxy)quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride
• [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine
• quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva
• Tarceva Hydrochloride See E625000
• Erlotinib HCl(TINIBS)
• Erlotinib hydrochloride
• ERLOTINIB
• 6,7-BIS(2-METHOXYETHOXY)-4-(3-ETHYNYLANILINO)QUINAZOLINE HCL
• ERLOTINIB HCL SALT :TARCEVA
• erlotinib hydorchloride
• N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva
• 21 Erlotinib hydrochloride and Intermediate
• Tarceva HydrochlorideSee E625000
• Erlotonid HCl

Erlotinib Hydrochloride

CAS: 183319-69-9

Formula: C₂₂H₂₃N₃O₄·HCl

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 429.90

Ref: 3B-E1404

Erlotinib Hydrochloride

CAS: 183319-69-9

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₂H₂₃N₃O₄·HCl

Colore e forma: Pale Yellow Powder

Peso molecolare: 429.14553

Ref: 45-1241608

Erlotinib hydrochloride

CAS: 183319-69-9

Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.

Formula: C₂₂H₂₃N₃O₄·HCl

Purezza: 99.78% - 99.85%

Colore e forma: White Or Off-White Powder

Peso molecolare: 429.9

Ref: TM-T0373L

4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1)

CAS: 183319-69-9

Formula: C₂₂H₂₃ClN₃O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 429.8967

Ref: IN-DA0027I4

Erlotinib Hydrochloride Salt

CAS: 183319-69-9

Erlotinib Hydrochloride Salt

Formula: C₂₂H₂₃N₃O₄·ClH

Purezza: By hplc: 99.9% by area (Typical Value in Batch COA)

Colore e forma: white to off-white crystalline solid

Peso molecolare: 429.90g/mol

Ref: 54-BIFK0020

Erlotinib hydrochloride

CAS: 183319-69-9

Erlotinib hydrochloride

Purezza: ≥98%

Peso molecolare: 429.9g/mol

Ref: 54-BUP17066

Erlotinib hydrochloride

CAS: 183319-69-9

Formula: C₂₂H₂₃N₃O₄·HCl

Purezza: ≥ 98.0% (dried basis)

Colore e forma: White to off-white powder

Peso molecolare: 429.90

Ref: 7W-GP3306

Erlotinib HCl

CAS: 183319-69-9

Formula: C₂₂H₂₃N₃O₄·HCl

Colore e forma: White To Off-White Solid

Peso molecolare: 393.44 36.46

Ref: 4Z-E-281

Erlotinib Hydrochloride

Prodotto controllato

CAS: 183319-69-9

Formula: C₂₂H₂₃N₃O₄·ClH

Colore e forma: Neat

Peso molecolare: 429.90

Ref: 86-MM3297.00

Erlotinib hydrochloride

CAS: 183319-69-9

Formula: C₂₂H₂₄ClN₃O₄

Purezza: 98%

Colore e forma: Solid, Crystalline Powder

Peso molecolare: 429.9

Ref: 10-F036497

Erlotinib Impurity 95

CAS: 183319-69-9

Formula: C₁₄H₈ClN₃O₂

Peso molecolare: 285.69

Ref: 4Z-E-28118

Tarceva (Erlotinib Hydrochloride)

Prodotto controllato

CAS: 183319-69-9

Applications Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. Antineoplastic.
References Moyer, J.D., et al.: Cancer Res., 57, 4838 (1997), Hidalgo, M., et al.: J. Clin. Oncol., 19, 3267 (2001), Perez-Soler, R., et al.: J. Clin. Oncol., 22, 3238 (2004), Blackhall, F.H., et al.: Expert Opin. Pharmacother., 6, 995 (2005),

Formula: C₂₂H₂₃N₃O₄·ClH

Colore e forma: Neat

Peso molecolare: 429.90

Ref: TR-T007500

Erlotinib Hydrochloride (Tarceva)

Prodotto controllato

CAS: 183319-69-9

Applications Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. Antineoplastic.
References Moyer, J.D., et al.: Cancer Res., 57, 4838 (1997), Hidalgo, M., et al.: J. Clin. Oncol., 19, 3267 (2001), Perez-Soler, R., et al.: J. Clin. Oncol., 22, 3238 (2004), Blackhall, F.H., et al.: Expert Opin. Pharmacother., 6, 995 (2005),

Formula: C₂₂H₂₃N₃O₄·ClH

Colore e forma: White To Light Yellow

Peso molecolare: 429.90

Ref: TR-E625000

Erlotinib HCl

CAS: 183319-69-9

Tyrosine kinase inhibitor; affects EGFR receptor; pancreatic cancer treatment

Formula: C₂₂H₂₃N₃O₄·HCl

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 429.9 g/mol

Ref: 3D-FE10803

Erlotinib hydrochloride - Bio-X ™

CAS: 183319-69-9

Erlotinib is a drug that is used to treat human malignancies. It is a type of kinase inhibitor that inhibits the EGFR tyrosine kinase, preventing the activation of downstream signalling pathways. Erlotinib has been shown to be effective in treating squamous cell carcinoma, melanoma, and other types of skin cancer. Additionally, Erlotinib has potential for use as an anti-inflammatory agent in the treatment of psoriasis and ulcerative colitis.

Formula: C₂₂H₂₃N₃O₄·HCl

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 429.9 g/mol

Ref: 3D-BE164421