CAS 18698-97-0

Acido 2-bromofenilacetico

Descrizione:

Acido 2-bromofenilacetico è un composto organico caratterizzato dalla sua struttura aromatica e dalla presenza di un atomo di bromo e di un gruppo funzionale acido carbossilico. Presenta un atomo di bromo attaccato alla seconda posizione di un anello fenilico, che è ulteriormente connesso a un gruppo di acido acetico. Questo composto appare tipicamente come un solido bianco o bianco sporco ed è solubile in solventi organici, con solubilità limitata in acqua a causa del suo componente aromatico idrofobico. La presenza del sostituente bromo può influenzare la sua reattività, rendendolo utile in varie sintesi chimiche e applicazioni, inclusi farmaci e agrochimici. Acido 2-bromofenilacetico può partecipare a varie reazioni chimiche, come sostituzioni nucleofile e reazioni di accoppiamento, grazie ai suoi gruppi funzionali. Inoltre, può mostrare attività biologica, che può essere esplorata nella chimica medicinale. I dati di sicurezza devono essere consultati per la manipolazione e lo stoccaggio, come con qualsiasi sostanza chimica, per garantire che vengano adottate le precauzioni appropriate.

Formula: C₈H₇BrO₂

InChI: InChI=1/C8H7BrO2/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4H,5H2,(H,10,11)/p-1

InChI key: InChIKey=DWXSYDKEWORWBT-UHFFFAOYSA-N

SMILES: c1ccc(c(c1)CC(=O)[O-])Br

Sinonimi:

• (2-Bromophenyl)Acetate
• -Rarechem Al Bo 0109
• 2-(2-Bromophenyl)acetic acid
• 2-Bromobenzeneacetic acid
• 2-Bromophenylacetic acid, 98+%
• Acetic acid, (o-bromophenyl)-
• Benzeneacetic acid, 2-bromo-
• Labotest-Bb Lt00454446
• O-Bromophenylacetic Acid
• Timtec-Bb Sbb006626

2-Bromophenylacetic Acid

CAS: 18698-97-0

Formula: C₈H₇BrO₂

Purezza: >98.0%(GC)(T)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 215.05

Ref: 3B-B1957

2-Bromophenylacetic acid, 98+%

CAS: 18698-97-0

Employed as a pharmaceutical intermediate. It is also used in organic synthesis. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code

Formula: C₈H₆BrO₂

Purezza: 98+%

Colore e forma: White to pale cream, Crystalline powder or powder or crystals

Peso molecolare: 214.04

Ref: 02-A16900

2-(2-Bromophenyl)acetic acid

CAS: 18698-97-0

Formula: C₈H₇BrO₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 215.0440

Ref: IN-DA00336R

2-Bromophenylacetic acid

CAS: 18698-97-0

Formula: C₈H₇BrO₂

Peso molecolare: 215.05

Ref: 7W-GK0619

2-Bromophenylacetic acid

CAS: 18698-97-0

2-Bromophenylacetic acid

Formula: C₈H₇BrO₂

Purezza: 98%

Colore e forma: white solid

Peso molecolare: 215.04g/mol

Ref: 54-OR11296

2-Bromophenylacetic acid

CAS: 18698-97-0

2-Bromophenylacetic acid is a potent inhibitor of the human enzyme COX-2. It has been shown to have anticancer activity, which may be due to its ability to inhibit cellular proliferation and induce apoptosis in cancer cells. This compound has been tested in a variety of experimental models, including chromatographic assays and striatal membrane preparations, with promising results. 2-Bromophenylacetic acid also has potent inhibitory activity on the human enzyme COX-2 and can be used as a dietary supplement for anticancer therapy.
COX-2 inhibitors are usually administered as ethyl esters or solutes in order to prevent degradation by esterases or glucuronidases. The 2-bromophenyl group is electron donating and this may increase the reactivity of the carbon adjacent to it and lead to an acylation reaction with nucleophilic groups such as thiols or amines.

Formula: C₈H₇BrO₂

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 215.04 g/mol

Ref: 3D-FB16015

2-Bromophenylacetic acid

CAS: 18698-97-0

Formula: C₈H₇BrO₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 215.046

Ref: 10-F001133

2-Bromophenylacetic Acid

Prodotto controllato

CAS: 18698-97-0

Applications 2-Bromophenylacetic Acid is used as the starting material in the synthesis of 2,3,3a,12b-Tetradehydro Asenapine (T291630); a degredation product of Asenapine (A788000) which is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist structurally related to Mianserin (M341500, HCl). Also used as an antipsychotic.
References Meltzer, H., et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A., et al.: Brain Res., 631, 191 (1993); Andree, B., et al.: Psychopharmacology, 131, 339 (1997); Richelson, E., et al.: Life Sci., 68, 29 (2000)

Formula: C₈H₇BrO₂

Colore e forma: Neat

Peso molecolare: 215.04

Ref: TR-B687905