CAS 1883548-86-4

PF-06260933 HCl

CAS: 1883548-86-4

PF-06260933 Dihydrochloride, a MAP4K4 inhibitor, hinders HGK, Mink, Tnik (IC50s: 140, 8, 13 nM) and lessens mouse fasting hyperglycemia.

Formula: C₁₆H₁₅Cl₃N₄

Colore e forma: Solid

Peso molecolare: 369.68

Ref: TM-T33945

PF 06260933 dihydrochloride

CAS: 1883548-86-4

PF 06260933 is a small-molecule that induces apoptosis in glioma cells by targeting mitogen-activated protein kinase (MAPK) and inhibiting the tumor suppressor gene p53. PF 06260933 binds to and inhibits MAPK, preventing the activation of downstream signaling proteins. PF 06260933 activates a process called large-scale genomic reorganization, which leads to cancer cell death. It is being investigated for the treatment of glioblastoma and other brain tumors. The drug has been shown to be effective in patients with malignant gliomas who have progressed on standard therapies.

Formula: C₁₆H₁₅Cl₃N₄

Purezza: Min. 95%

Peso molecolare: 369.7 g/mol

Ref: 3D-IAD54886