CAS 188627-80-7

Eptifibatide

Descrizione:

Eptifibatide è un eptapeptide ciclico sintetico che funge da potente agente antipiastrinico, utilizzato principalmente nella gestione delle sindromi coronariche acute e durante le interventi coronariche percutanee. Agisce come un inibitore reversibile del recettore della glicoproteina IIb/IIIa sulle piastrine, prevenendo così l'aggregazione piastrinica e la formazione di trombi. Eptifibatide è derivato dal veleno del serpente a sonagli pigmeo del sud-est ed è caratterizzato dalla sua affinità di legame specifica al recettore, che è cruciale per l'attivazione piastrinica. La sostanza viene tipicamente somministrata per via endovenosa e ha una emivita relativamente breve, richiedendo un'infusione continua in contesti clinici. Eptifibatide è generalmente ben tollerato, sebbene possa essere associato a rischi di sanguinamento, in particolare in pazienti con una storia di disturbi emorragici o in quelli sottoposti a procedure chirurgiche. La sua farmacocinetica e farmacodinamica lo rendono uno strumento prezioso nella cura cardiovascolare acuta, contribuendo a migliorare i risultati nei pazienti ad alto rischio.

Formula: C₃₅H₄₉N₁₁O₉S₂

InChI: InChI=1/C35H49N11O9S2/c36-31(52)26-17-57-56-12-10-27(47)43-22(7-3-4-11-39-35(37)38)32(53)41-16-28(48)44-25(14-29(49)50)34(55)45-24(13-18-15-40-20-6-2-1-5-19(18)20)30(51)21-8-9-23(42-21)33(54)46-26/h1-2,5-6,15,21-26,40,42H,3-4,7-14,16-17H2,(H2,36,52)(H,41,53)(H,43,47)(H,44,48)(H,45,55)(H,46,54)(H,49,50)(H4,37,38,39)/t21?,22-,23-,24-,25-,26-/m0/s1

SMILES: c1ccc2c(c1)c(C[C@H]1C(=O)C3CC[C@@H](C(=N[C@@H](CSSCCC(=N[C@@H](CCCCNC(=N)N)C(=NCC(=N[C@@H](CC(=O)O)C(=N1)O)O)O)O)C(=N)O)O)N3)c[nH]2

Sinonimi:

• [3-carbamoyl-11-{4-[(diaminomethylidene)amino]butyl}-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxodocosahydro-7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl]acetic acid
• [(1S,4R,12S,18S,21S)-12-(4-carbamimidamidobutyl)-4-carbamoyl-21-(1H-indol-3-ylmethyl)-2,10,13,16,19,22-hexaoxo-6,7-dithia-3,11,14,17,20,26-hexaazabicyclo[21.2.1]hexacos-18-yl]acetic acid
• Map-Lys-Gly-Asp-Trp-Pro-Cys-Nh2
• Integrelin
• N6-(Aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl-L-lysylglycyl-L-a-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide
• [(3R,11S,17S,20S,25aS)-11-(4-carbamimidamidobutyl)-3-carbamoyl-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxodocosahydro-7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl]acetic acid
• Eptifibatide Acetate

Eptifibatide

CAS: 188627-80-7

Eptifibatide, a RGD mimetic, is a glycoprotein (GP) IIb/IIIa receptor antagonist. Clinically, the peptide is used as an antiplatelet drug in combination with heparin and aspirin in the management of unstable angina and in patients undergoing coronary angioplasty and stenting procedures. CAS Number (eptifibatide acetate): 148031-34-9.

Formula: C₃₅H₄₉N₁₁O₉S₂

Purezza: ≥99%

Colore e forma: White Lyophilisate

Peso molecolare: 831.97

Ref: 01-4063191

Eptifibatide

CAS: 188627-80-7

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₃₅H₄₉N₁₁O₉S₂

Colore e forma: White Powder

Peso molecolare: 831.31561

Ref: 45-1238501

L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1→6)-disulfide

CAS: 188627-80-7

Formula: C₃₅H₄₉N₁₁O₉S₂

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 831.9619

Ref: IN-DA001FDT

Eptifibatide

CAS: 188627-80-7

Formula: C₃₅H₄₉N₁₁O₉S₂

Peso molecolare: 831.96

Ref: 7W-GP0493

Eptifibatide Acetate

CAS: 188627-80-7

Formula: C₃₅H₄₉N₁₁O₉S₂

Purezza: 95%~99%

Colore e forma: White to Off-white Powder

Peso molecolare: 831.962

Ref: BP-BPPG027

Eptifibatide

CAS: 188627-80-7

Formula: C₃₅H₄₉N₁₁O₉S₂

Peso molecolare: 831.97

Ref: 4Z-PE-126001

Human Eptifibatide

CAS: 188627-80-7

Human Eptifibatide

Colore e forma: White Lyophilised Powder

Peso molecolare: 831.96g/mol

Ref: 54-BITP1545

Eptifibatide

Prodotto controllato

CAS: 188627-80-7

Applications An arginine-glycine-aspartate-mimetic, reversibly binds to platelets to reduce the risk of cardiac ischemic events.
References Pathak, A., et al.: Cardiovas. Diabetol., 7 (2008), Hantgan, R., et al.: Biochem., 48, 8355 (2009), Giugliano, R., et al.: New Eng. J. Med., 360, 2176 (2009),

Formula: C₃₅H₄₉N₁₁O₉S₂

Colore e forma: Off White Solid

Peso molecolare: 831.96

Ref: TR-E592000

Eptifibatide acetate

Prodotto controllato

CAS: 188627-80-7

Inhibits platelet glycoprotein IIb/IIIa receptors

Formula: C₃₅H₄₉N₁₁O₉S₂·xC₂H₄O₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 831.96 g/mol

Ref: 3D-FE40869

Eptifibatide

CAS: 188627-80-7

Eptifibatide is a drug that is used in the treatment of congestive heart failure, acute coronary syndrome and peripheral artery disease. It is a glycoprotein IIb/IIIa inhibitor that binds to integrin receptors on platelets and prevents them from binding to fibrinogen. This prevents blood clotting and reduces the risk of stroke or heart attack. Eptifibatide has been shown to be effective for the treatment of bowel disease, infectious diseases, and experimental models of myocardial infarcts. The drug has significant cytotoxicity, which may be due to its ability to inhibit cell proliferation by blocking protein synthesis at the ribosome level.
Eptifibatide has been shown to have a disulfide bond between two cysteine residues located in its amino-terminal region. This bond stabilizes the molecule in solution and ensures that it remains active until it reaches its target site.

Formula: C₃₅H₄₉N₁₁O₉S₂

Purezza: Min. 95%

Peso molecolare: 831.98 g/mol

Ref: 3D-EPT-3786-PI