CAS 188968-51-6

Acido 2-[(2S,5R,8S,11S)-5-benzil-11-[3-(diaminometilidenamino)propil]-7-metil-3,6,9,12,15-pentaoxo-8-propan-2-il-1,4,7,10,13-pentazaciclopentadec-2-il]acetico

Descrizione:

La sostanza chimica nota come Acido 2-[(2S,5R,8S,11S)-5-benzil-11-[3-(diaminometilidenamino)propil]-7-metil-3,6,9,12,15-pentaoxo-8-propan-2-il-1,4,7,10,13-pentazaciclopentadec-2-il]acetico, con il numero CAS 188968-51-6, è un composto organico complesso caratterizzato dalla sua struttura multiciclica e dalla presenza di più gruppi funzionali. Questo composto presenta uno scheletro di pentazaciclopentadecano, che contribuisce alla sua unica conformazione tridimensionale e alla potenziale attività biologica. La presenza di un gruppo benzilico e di un moiety diaminometilidenoamminico suggerisce che potrebbe mostrare interazioni interessanti con bersagli biologici, influenzando possibilmente le sue proprietà farmacologiche. Inoltre, il gruppo funzionale acido acetico indica un potenziale per la solubilità in solventi polari e potrebbe svolgere un ruolo nella reattività del composto. In generale, la struttura intricata e la diversità funzionale di questa sostanza la rendono un candidato per ulteriori indagini in chimica medicinale e campi correlati.

Formula: C₂₇H₄₀N₈O₇

InChI: InChI=1/C27H40N8O7/c1-15(2)22-25(41)33-17(10-7-11-30-27(28)29)23(39)31-14-20(36)32-18(13-21(37)38)24(40)34-19(26(42)35(22)3)12-16-8-5-4-6-9-16/h4-6,8-9,15,17-19,22H,7,10-14H2,1-3H3,(H,31,39)(H,32,36)(H,33,41)(H,34,40)(H,37,38)(H4,28,29,30)/t17-,18-,19+,22-/m0/s1

Sinonimi:

• Cilengitide
• cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl)
• cyclo[L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl-N~5~-(diaminomethylidene)-L-ornithylglycyl]

Cilengitide

CAS: 188968-51-6

The cyclic RGD peptide cilengitide is a potential cancer drug. Cilengitide is under investigation for the treatment of glioblastoma, where it may act by inhibiting angiogenesis, and influencing tumor invasion and proliferation.

Formula: C₂₇H₄₀N₈O₇

Purezza: 97.6%

Colore e forma: White

Peso molecolare: 588.66

Ref: 01-4060586

Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-N-methyl-L-valyl)

CAS: 188968-51-6

Formula: C₂₇H₄₀N₈O₇

Purezza: 90%

Colore e forma: Solid

Peso molecolare: 588.6559

Ref: IN-DA002HLG

Cilengitide

CAS: 188968-51-6

Cilengitide

Purezza: ≥98%

Peso molecolare: 588.66g/mol

Ref: 54-BUP07988

Cilengitide

CAS: 188968-51-6

Formula: C₂₇H₄₀N₈O₇

Purezza: 95%~99%

Colore e forma: White to Off-white Powder

Peso molecolare: 588.66

Ref: BP-BPPG018

Cilengitide

CAS: 188968-51-6

Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.

Formula: C₂₇H₄₀N₈O₇

Purezza: 98% - 99.8%

Colore e forma: Solid

Peso molecolare: 588.66

Ref: TM-T2494

Cilengitide

CAS: 188968-51-6

Cilengitide is a new chemotherapeutic agent that was shown to be effective against renal cell cancer in vitro. Cilengitide inhibits the polymerase chain reaction, arresting the growth of cells. It has minimal toxicity and natural compounds, which make it a promising drug for the treatment of human cancers. Cilengitide binds to integrin receptors on malignant brain cells and inhibits their ability to migrate, inducing apoptosis. This drug also inhibits the production of chemoattractant protein and can be used as an adjuvant therapy for radiation and antibiotic-resistant strains of bacteria.

Formula: C₂₇H₄₀N₈O₇

Purezza: Min. 95%

Peso molecolare: 588.67 g/mol

Ref: 3D-RGD-3036-PI

Cilengitide

CAS: 188968-51-6

Purezza: 98%

Peso molecolare: 588.302

Ref: 10-F813353

Cilengitide

CAS: 188968-51-6

Cilengitide is a peptide that inhibits the integrin receptor, which may be involved in tumorigenesis. It blocks the process of cellular transformation and inhibits tumor growth by blocking angiogenesis. Cilengitide has been shown to have minimal toxicity in vitro and in vivo, which is likely due to its low solubility in water. This peptide also has antitumor activity against solid tumours and can inhibit the growth of human breast cancer cells. Cilengitide was found to be effective in an experimental model using MDA-MB-231 breast cancer cells, demonstrating its potential for use as a therapeutic agent for cancer treatment.

Formula: C₂₇H₄₀N₈O₇

Purezza: Min. 95%

Peso molecolare: 588.66 g/mol

Ref: 3D-NHA96851