CAS 189060-13-7

LAPAQUISTAT

Descrizione:

LAPAQUISTAT, identificato dal suo numero CAS 189060-13-7, è un composto chimico che funge principalmente da agente farmacologico. È noto per il suo ruolo di inibitore selettivo dell'enzima acil-CoA:colesterolo aciltransferasi (ACAT), coinvolto nel metabolismo del colesterolo. Questa inibizione può portare a una riduzione dell'assorbimento del colesterolo e può avere implicazioni per il trattamento di condizioni legate alla dislipidemia e alle malattie cardiovascolari. LAPAQUISTAT è caratterizzato dalla sua specifica struttura molecolare, che contribuisce alla sua attività biologica e selettività. Il composto è stato oggetto di vari studi per valutare la sua efficacia e il profilo di sicurezza in contesti clinici. Come molti agenti farmaceutici, il suo uso può essere associato a potenziali effetti collaterali, e la sua farmacocinetica, inclusi assorbimento, distribuzione, metabolismo ed escrezione, è fondamentale per comprendere il suo potenziale terapeutico. In generale, LAPAQUISTAT rappresenta un'area significativa di interesse nello sviluppo di terapie per la riduzione del colesterolo.

Formula: C₃₃H₄₁ClN₂O₉

InChI: InChI=1S/C33H41ClN2O9/c1-20(37)44-19-33(2,3)18-36-25-10-9-22(34)16-24(25)30(23-7-6-8-26(42-4)31(23)43-5)45-27(32(36)41)17-28(38)35-13-11-21(12-14-35)15-29(39)40/h6-10,16,21,27,30H,11-15,17-19H2,1-5H3,(H,39,40)/t27-,30-/m1/s1

InChI key: InChIKey=CMLUGNQVANVZHY-POURPWNDSA-N

SMILES: O(C)C1=C([C@@H]2C=3C(N(CC(COC(C)=O)(C)C)C(=O)[C@@H](CC(=O)N4CCC(CC(O)=O)CC4)O2)=CC=C(Cl)C3)C=CC=C1OC

Sinonimi:

• 1-((1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2\r\n,3,5-tetrahydro-4,1-benzoxazepin-3-yl)acetyl)piperidine-4-acetic acid
• 1-[2-[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid
• 2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3- dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo(e)(1,4)oxazepin-3- yl)acetyl)piperidin-4-yl)acetic acid
• 4-Piperidineacetic acid, 1-(((3R,5S)-1-(3-(acetyloxy)-2,2-dimethylpropyl)-7- chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3- yl)acetyl)-
• 4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-
• 4-Piperidineacetic acid, 1-[[1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-, (3R-trans)-
• Lapaquistat acetate
• Lapaquistat acetate [USAN]
• Tak 475
• Unii-Iuh3Ay74O3
• Lapaquistat Acetate (TAK-475)
• 1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid
• CS-1400
• LAPAQUISTAT
• 2-[1-[2-[1-(3-Acetoxy-2,2-diMethylpropyl)-7-chloro-5(S)-(2,3-diMethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3(R)-yl]acetyl]piperidin-4-yl]acetic acid

2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid

CAS: 189060-13-7

2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid

Purezza: 98%

Peso molecolare: 645.15g/mol

Ref: 54-OR1062987

Lapaquistat Acetate

Prodotto controllato

CAS: 189060-13-7

Applications A novel squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Treatment with Lapaquistat acetate increased collagen concentration and transformed coronary plaques into fibromuscular plaques. Lapaquistat acetate also suppressed the expression of matrix metalloproteinase-1 and plasminogen activator inhibitor-1 in the plaque and increased peripheral coenzyme Q10 levels.Antiarteriosclerotics.
References Amano, Y., et al.: Eur. J. Pharmacol., 466, 155 ( 2003), Hiyoshi, H., et al.: J. Lipid Res., 44, 128 (2003), Miki, T., et al.: J. Med. Chem., 45, 4571 (2002), Shiomi, M., et al.: Atherosclerosis, 178, 287 (2005),

Formula: C₃₃H₄₁ClN₂O₉

Colore e forma: Neat

Peso molecolare: 645.14

Ref: TR-L175500

Lapaquistat acetate

CAS: 189060-13-7

LAPAQ is a hydroxyl-containing fatty acid that is synthesized by the liver and is used as a co-therapy for lowering low-density lipoprotein cholesterol. LAPAQ has been shown to have a chemical stability that is 8 times higher than that of other drugs, which may be due to its ester linkages. This drug also has anti-inflammatory properties, which are due to its ability to inhibit the production of high-sensitivity c-reactive protein (hsCRP). LAPAQ inhibits the activity of 3 enzymes involved in cholesterol synthesis, including 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase), acetyl coenzyme A cholesterol acyltransferase (ACAT), and lysophospholipid acyltransferase. It also inhibits the transcriptional regulation of low density lipoprotein cholesterols.

Formula: C₃₃H₄₁ClN₂O₉

Purezza: Min. 95%

Peso molecolare: 645.14 g/mol

Ref: 3D-PHA06013

Lapaquistat acetate

CAS: 189060-13-7

Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor that reduces the cytotoxicity induced by statins in human skeletal muscle cells.

Formula: C₃₃H₄₁ClN₂O₉

Purezza: 99.38% - 99.94%

Colore e forma: Solid

Peso molecolare: 645.14

Ref: TM-T15709