CAS 18942-26-2

Acido chebulinico

Descrizione:

Acido chebulinico è un composto polifenolico che si trova naturalmente principalmente nel frutto dell'albero Terminalia chebula, noto per le sue proprietà medicinali nella medicina tradizionale. È caratterizzato dalla sua struttura complessa, che include più gruppi idrossilici che contribuiscono alla sua attività antiossidante. Il composto presenta una gamma di attività biologiche, comprese proprietà antinfiammatorie, antimicrobiche e anticancro, rendendolo di interesse nella ricerca farmacologica. Acido chebulinico è solubile in acqua e solventi organici, il che ne migliora la biodisponibilità. La sua struttura chimica gli consente di interagire con vari bersagli biologici, potenzialmente modulando le vie cellulari. Inoltre, è spesso studiato per il suo ruolo nella promozione dei benefici per la salute, come il miglioramento delle funzioni metaboliche e la protezione dallo stress ossidativo. In generale, Acido chebulinico rappresenta un'area significativa di studio nella chimica dei prodotti naturali e nelle sue applicazioni in salute e medicina.

Formula: C₄₁H₃₂O₂₇

InChI: InChI=1S/C41H32O27/c42-15-1-10(2-16(43)26(15)51)35(56)62-9-22-31-33(66-36(57)11-3-17(44)27(52)18(45)4-11)34(41(63-22)68-37(58)12-5-19(46)28(53)20(47)6-12)67-38(59)13-7-21(48)29(54)32-25(13)24(30(55)40(61)65-32)14(8-23(49)50)39(60)64-31/h1-7,14,22,24,30-31,33-34,41-48,51-55H,8-9H2,(H,49,50)/t14-,22+,24-,30+,31+,33-,34+,41-/m0/s1

InChI key: InChIKey=YGVHOSGNOYKRIH-AVXZFDTDSA-N

SMILES: C(C(O)=O)[C@H]1[C@]2(C=3C(C(=O)O[C@@]4([C@@H](OC(=O)C5=CC(O)=C(O)C(O)=C5)[C@](OC1=O)([C@@H](COC(=O)C6=CC(O)=C(O)C(O)=C6)O[C@H]4OC(=O)C7=CC(O)=C(O)C(O)=C7)[H])[H])=CC(O)=C(O)C3OC(=O)[C@@H]2O)[H]

Sinonimi:

• (3,15,16-Trihydroxy-2,5,13-Trioxo-10,17-Bis[(3,4,5-Trihydroxybenzoyl)Oxy]-8-{[(3,4,5-Trihydroxybenzoyl)Oxy]Methyl}-2,3,3A,4,5,7,8,10,11,13-Decahydro-7,11-Methano[1,4,7]Trioxacyclotridecino[11,10,9-De]Chromen-4-Yl)Acetic Acid
• 7,11-Methanopyrano[4,3,2-kl][2,5,8]benzotrioxacyclotridecin, β-<span class="text-smallcaps">D</span>-glucopyranose deriv.
• Eutannin
• NSC 69862
• Nsc69862
• [(3S,3aS,4R,7R,8R,10S,11R,17S)-3,15,16-trihydroxy-2,5,13-trioxo-10,17-bis[(3,4,5-trihydroxybenzoyl)oxy]-8-{[(3,4,5-trihydroxybenzoyl)oxy]methyl}-2,3,3a,4,5,7,8,10,11,13-decahydro-7,11-methano[1,4,7]trioxacyclotridecino[11,10,9-de]chromen-4-yl]acetic acid
• [(3S,3aS,4S,7R,8R,10S,11R,17S)-3,15,16-trihydroxy-2,5,13-trioxo-10,17-bis[(3,4,5-trihydroxybenzoyl)oxy]-8-{[(3,4,5-trihydroxybenzoyl)oxy]methyl}-2,3,3a,4,5,7,8,10,11,13-decahydro-7,11-methano[1,4,7]trioxacyclotridecino[11,10,9-de]chromen-4-yl]acetic acid
• [(3S,4S)-3,15,16-trihydroxy-2,5,13-trioxo-10,17-bis[(3,4,5-trihydroxybenzoyl)oxy]-8-{[(3,4,5-trihydroxybenzoyl)oxy]methyl}-2,3,3a,4,5,7,8,10,11,13-decahydro-7,11-methano[1,4,7]trioxacyclotridecino[11,10,9-de]chromen-4-yl]acetic acid
• β-<span class="text-smallcaps">D</span>-Glucopyranose, 1,3,6-tris(3,4,5-trihydroxybenzoate), cyclic 2→2:4→1-ester with (2S)-[(3R,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid
• Chebulinic acid
• β-D-Glucopyranose, 1,3,6-tris(3,4,5-trihydroxybenzoate), cyclic 2→2:4→1-ester with (2S)-[(3R,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid

Chebulinic acid

CAS: 18942-26-2

Formula: C₄₁H₃₂O₂₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 956.6766

Ref: IN-DA00ABR9

Chebulinic acid

CAS: 18942-26-2

Chebulinic acid

Purezza: ≥98%

Peso molecolare: 956.68g/mol

Ref: 54-BUP12585

Chebulinic acid

CAS: 18942-26-2

Formula: C₄₁H₃₂O₂₇

Purezza: 95%~99%

Peso molecolare: 956.68

Ref: BP-BP0339

Chebulinic acid

CAS: 18942-26-2

Formula: C₄₁H₃₂O₂₇

Purezza: ≥ 95.0%

Colore e forma: White to off-white solid

Peso molecolare: 956.68

Ref: 7W-GK3169

Chebulinic acid

CAS: 18942-26-2

Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.

Formula: C₄₁H₃₂O₂₇

Purezza: 98.91% - 99.71%

Colore e forma: Solid

Peso molecolare: 956.68

Ref: TM-TQ0184

Chebulinic acid

CAS: 18942-26-2

Natural glycoside

Formula: C₄₁H₃₂O₂₇

Purezza: ≥ 90.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 956.69

Ref: 5G-80572

Chebulinic Acid

CAS: 18942-26-2

Applications Chebulinic Acid has been shown to prevent epithelial mesenchymal transition in retinal pigment epithelial cells through inhibition of SMAD-3 phosphorylation. This prevents retinal detachment in the process of proliferative vitreoretinopathy.
References Sivasankar, S. et al.: PLoS One., 10, e0120512 (2015);

Formula: C₄₁H₃₂O₂₇

Colore e forma: Off-White

Peso molecolare: 956.68

Ref: TR-C291895

Chebulinic acid

CAS: 18942-26-2

Chebulinic acid is a polyphenolic compound, which is derived primarily from the fruits of Terminalia chebula, a species belonging to the Combretaceae family. Terminalia chebula is a deciduous tree native to southern Asia, and its fruits have been extensively used in traditional medicinal systems such as Ayurveda due to their pharmacological potential.

Formula: C₄₁H₃₂O₂₇

Purezza: Min 98%

Ref: 3D-FC138782