CAS 190448-57-8

Ezetimibe glucuronide

Descrizione:

Ezetimibe glucuronide è un metabolita dell'inibitore dell'assorbimento del colesterolo ezetimibe, formato principalmente attraverso il processo di glucuronidazione nel fegato. Questo composto è caratterizzato dal suo ruolo nel migliorare gli effetti farmacologici dell'ezetimibe aumentando la sua solubilità e facilitandone l'escrezione. L'ezetimibe stesso agisce inibendo selettivamente l'assorbimento intestinale di colesterolo, abbassando così i livelli di colesterolo sierico. La forma glucuronide è tipicamente più polare, il che può influenzare la sua biodisponibilità e farmacocinetica. In termini di struttura chimica, Ezetimibe glucuronide presenta un gruppo acido glucuronico legato alla molecola di ezetimibe, il che altera la sua interazione con i sistemi biologici. Questa modifica può influenzare la sua efficacia e il profilo di sicurezza, rendendola una considerazione importante nella farmacoterapia per l'iperlipidemia. Il composto è generalmente studiato nel contesto del metabolismo dei farmaci e della farmacodinamica, contribuendo a una migliore comprensione di come l'ezetimibe funzioni nel corpo e dei suoi potenziali benefici terapeutici.

Formula: C₃₀H₂₉F₂NO₉

InChI: InChI=1S/C30H29F2NO9/c31-17-5-1-15(2-6-17)22(34)14-13-21-23(33(28(21)38)19-9-7-18(32)8-10-19)16-3-11-20(12-4-16)41-30-26(37)24(35)25(36)27(42-30)29(39)40/h1-12,21-27,30,34-37H,13-14H2,(H,39,40)/t21-,22+,23-,24+,25+,26-,27+,30-/m1/s1

InChI key: InChIKey=UOFYCFMTERCNEW-ADEYADIWSA-N

SMILES: C(C[C@H](O)C1=CC=C(F)C=C1)[C@@H]2[C@H](N(C2=O)C3=CC=C(F)C=C3)C4=CC=C(O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)C=C4

Sinonimi:

• 4-[(2S,3R)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-2-azetidinyl]phenyl β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid
• 4-[(2S,3R)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-2-azetidinyl]phenyl-D-Glucopyranosiduronic Acid
• Ezetimibe -D-Glucuronide, >85%
• Ezetimibe B-D-Glucuronide
• Ezetimibe glucuronide
• Ezm-G
• Sch 58235 Glucuronide
• Sch 60663
• β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, 4-[(2S,3R)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-2-azetidinyl]phenyl
• β-D-Glucopyranosiduronic acid, 4-[(2S,3R)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-2-azetidinyl]phenyl
• 4-[(2S,3R)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-2-azetidinyl]phenyl β-D-glucopyranosiduronic acid

Ezetimibe glucuronide

CAS: 190448-57-8

Formula: C₃₀H₂₉F₂NO₉

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 585.5494

Ref: IN-DA002EKX

Ezetimibe Phenoxy Glucuronide-d4

CAS: 190448-57-8

Formula: C₃₀H₂₅D₄F₂NO₉

Colore e forma: White To Off-White Solid

Peso molecolare: 589.58

Ref: 4Z-E-065

Ezetimibe Phenoxy Glucuronide

CAS: 190448-57-8

Formula: C₃₀H₂₉F₂NO₉

Colore e forma: White To Off-White Solid

Peso molecolare: 585.56

Ref: 4Z-E-062

Ezetimibe phenoxy glucuronide

CAS: 190448-57-8

Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity.

Formula: C₃₀H₂₉F₂NO₉

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 585.55

Ref: TM-T11253

Ezetimibe phenoxy glucuronide

CAS: 190448-57-8

Colore e forma: Solid

Peso molecolare: 585.557

Ref: 10-F987045

Ezetimibe phenoxy-β-D-glucuronide

CAS: 190448-57-8

Ezetimibe phenoxy-β-D-glucuronide

Purezza: 98%

Peso molecolare: 585.55g/mol

Ref: 54-BICL2231

Ezetimibe b-D-glucuronide

CAS: 190448-57-8

Ref: 7W-GC0776

Ezetimibe Phenoxy β-D-Glucuronide

Prodotto controllato

CAS: 190448-57-8

Stability Hygroscopic
Applications Phase-II metabolite of Ezetimibe, an antihyperlipoproteinemic. A Cholesterol absorption inhibitor.This compound is very hygroscopic. Handle with care.
References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)

Formula: C₃₀H₂₉F₂NO₉

Colore e forma: White To Light Brown

Peso molecolare: 585.55

Ref: TR-E975030

Ezetimibe b-D-glucuronide

CAS: 190448-57-8

Ezetimibe b-D-glucuronide is a glucuronide conjugate of ezetimibe. It can be found in human serum, as well as in the liver and small intestine. Ezetimibe b-D-glucuronide has been shown to inhibit uptake of uridine into Caco2 cells, which may be due to its ability to inhibit the activity of drug transporters such as P-glycoprotein and organic anion transporting polypeptides. This drug also inhibits the production of creatine kinase in the liver and lowers cholesterol levels by inhibiting dietary cholesterol absorption. The drug interactions with statins are still unclear and require further investigation. Ezetimibe b-D-glucuronide is metabolized by glucuronidation in the liver and small intestine.

Formula: C₃₀H₂₉F₂NO₉

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 585.55 g/mol

Ref: 3D-ME07193

Ezetimibe Phenoxy β-D-Glucuronide

CAS: 190448-57-8

Formula: C₃₀H₂₉F₂NO₉

Peso molecolare: 585.56

Ref: ST-EA-CP-E6044