CAS 191114-48-4

Telitromicina

Descrizione:

Telitromicina è un antibiotico sintetico appartenente alla classe dei chetolidi, utilizzato principalmente per trattare infezioni delle vie respiratorie causate da vari batteri. Presenta un ampio spettro di attività contro organismi Gram-positivi e alcuni Gram-negativi, rendendolo efficace contro patogeni come Streptococcus pneumoniae e Haemophilus influenzae. Telitromicina agisce inibendo la sintesi proteica batterica legandosi alla subunità ribosomiale 50S, impedendo così la crescita e la riproduzione dei batteri. La sua struttura chimica presenta un gruppo chetonico e uno scheletro macrolidico, che contribuiscono alle sue uniche proprietà farmacologiche. Telitromicina viene somministrato per via orale ed è noto per la sua relativamente lunga emivita, che consente una somministrazione una volta al giorno. Tuttavia, è associato a potenziali effetti collaterali, tra cui disturbi gastrointestinali e, in rari casi, tossicità epatica. A causa di preoccupazioni riguardo alla resistenza e alla sicurezza, il suo uso è diventato più ristretto negli ultimi anni. In generale, Telitromicina rappresenta un'opzione importante nell'arsenale degli antibiotici, particolarmente per il trattamento di specifiche infezioni batteriche.

Formula: C₄₃H₆₅N₅O₁₀

InChI: InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1

InChI key: InChIKey=LJVAJPDWBABPEJ-PNUFFHFMSA-N

SMILES: C[C@@]12[C@](N(CCCCN3C=C(N=C3)C=4C=CC=NC4)C(=O)O1)([C@@H](C)C(=O)[C@H](C)C[C@](OC)(C)[C@H](O[C@H]5[C@H](O)[C@@H](N(C)C)C[C@@H](C)O5)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC)[H]

Sinonimi:

• (1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone
• (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-<span class="text-smallcaps">D</span>-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
• (3aS,4S,7R,9R,10R,11R,13R,15S,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside - 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione (1:1)
• (3aS,4S,7R,9R,10R,11S,13R,15S,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside
• 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-<span class="text-smallcaps">D</span>-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-
• Erythromycin, 3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</span>-ribo-hexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]-
• Hmr 3647
• Ketek
• Levviax
• Ru 66647
• (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
• 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-

2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-

CAS: 191114-48-4

Formula: C₄₃H₆₅N₅O₁₀

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 812.0037

Ref: IN-DA002F1S

Telithromycin

CAS: 191114-48-4

Formula: C₄₃H₆₅N₅O₁₀

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 812.00

Ref: 7W-GA2425

Telithromycin

CAS: 191114-48-4

Telithromycin is a macrolide antibiotic and erythromycin derivative,70S bacterial ribosome, antimicrobial, respiratory infections,inhibits protein synthesis.

Formula: C₄₃H₆₅N₅O₁₀

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 812

Ref: TM-T4543

Telithromycin

CAS: 191114-48-4

Formula: C₄₃H₆₅N₅O₁₀

Peso molecolare: 812.02

Ref: 4Z-T-443001

Telithromycin 90%

Prodotto controllato

CAS: 191114-48-4

Applications Telithromycin is a ketolide antibiotic, used to treat respiratory infections
References Lee, J., et al.: Pulmonary Pharmacology & Therapeutics, 21, 860 (2008), Wajima, T., et al.: J. Med. Microbiol., 57, 1383 (2008), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009),

Formula: C₄₃H₆₅N₅O₁₀

Purezza: 90%

Colore e forma: Light Orange Colour

Peso molecolare: 812.00

Ref: TR-T016500

Telithromycin - 95%

CAS: 191114-48-4

Ketolide; binds bacterial ribosomes and inhibits translation

Formula: C₄₃H₆₅N₅O₁₀

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 812 g/mol

Ref: 3D-AT164862

Telithromycin

CAS: 191114-48-4

Ketolide; binds bacterial ribosomes and inhibits translation

Formula: C₄₃H₆₅N₅O₁₀

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 812 g/mol

Ref: 3D-AT28021

Telithromycin, 95%

CAS: 191114-48-4

Telithromycin is used to treat respiratory infections. Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Formula: C₄₃H₆₅N₅O₁₀

Purezza: 95%

Colore e forma: Crystalline solid

Peso molecolare: 812.02

Ref: 02-J66820