CAS 191114-48-4: Telitromicina

Descrizione: Telitromicina è un antibiotico sintetico appartenente alla classe dei chetolidi, utilizzato principalmente per trattare infezioni delle vie respiratorie causate da vari batteri. Presenta un ampio spettro di attività contro organismi Gram-positivi e alcuni Gram-negativi, rendendolo efficace contro patogeni come Streptococcus pneumoniae e Haemophilus influenzae. Telitromicina agisce inibendo la sintesi proteica batterica legandosi alla subunità ribosomiale 50S, impedendo così la crescita e la riproduzione dei batteri. La sua struttura chimica presenta un gruppo chetonico e uno scheletro macrolidico, che contribuiscono alle sue uniche proprietà farmacologiche. Telitromicina viene somministrato per via orale ed è noto per la sua relativamente lunga emivita, che consente una somministrazione una volta al giorno. Tuttavia, è associato a potenziali effetti collaterali, tra cui disturbi gastrointestinali e, in rari casi, tossicità epatica. A causa di preoccupazioni riguardo alla resistenza e alla sicurezza, il suo uso è diventato più ristretto negli ultimi anni. In generale, Telitromicina rappresenta un'opzione importante nell'arsenale degli antibiotici, particolarmente per il trattamento di specifiche infezioni batteriche.

Formula: C₄₃H₆₅N₅O₁₀

InChI: InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1

InChI key: InChIKey=LJVAJPDWBABPEJ-PNUFFHFMSA-N

SMILES: O=C1OC2(C)C(OC(=O)C(C(=O)C(C)C(OC3OC(C)CC(N(C)C)C3O)C(OC)(C)CC(C(=O)C(C)C2N1CCCCN4C=NC(=C4)C=5C=NC=CC5)C)C)CC

Sinonimi:

• (1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone
• (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-<span class="text-smallcaps">D</span>-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
• (3aS,4S,7R,9R,10R,11R,13R,15S,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside - 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione (1:1)
• (3aS,4S,7R,9R,10R,11S,13R,15S,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside
• 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-<span class="text-smallcaps">D</span>-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-
• Erythromycin, 3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</span>-ribo-hexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]-
• Hmr 3647
• Ketek
• Levviax
• Ru 66647
• (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
• 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-
• Erythromycin, 3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]-

Telithromycin, 95%

CAS: 191114-48-4

Telithromycin is used to treat respiratory infections. Telithromycin prevents bacteria from growing, by interfering with …

• Formula: C₄₃H₆₅N₅O₁₀
• Purezza: 95%
• Colore e forma: Crystalline solid
• Peso molecolare: 812.02

2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-

CAS: 191114-48-4

• Formula: C₄₃H₆₅N₅O₁₀
• Purezza: 99%
• Colore e forma: Solid
• Peso molecolare: 812.0037

Telithromycin

CAS: 191114-48-4

• Formula: C₄₃H₆₅N₅O₁₀
• Purezza: ≥ 98.0%
• Colore e forma: White to off-white powder
• Peso molecolare: 812.00

Telithromycin

CAS: 191114-48-4

Telithromycin (HMR3647) is a ketolide antibiotic to treat community acquired pneumonia of mild to moderate …

• Formula: C₄₃H₆₅N₅O₁₀
• Purezza: 98%
• Colore e forma: Solid
• Peso molecolare: 812.02

Telithromycin

CAS: 191114-48-4

• Formula: C₄₃H₆₅N₅O₁₀
• Peso molecolare: 812.02

Telithromycin 90%

CAS: 191114-48-4

Applications Telithromycin is a ketolide antibiotic, used to treat respiratory infections References Lee, J., et …

• Formula: C₄₃H₆₅N₅O₁₀
• Purezza: 90%
• Colore e forma: Light Orange Colour
• Peso molecolare: 812.00

Telithromycin

CAS: 191114-48-4

Ketolide; binds bacterial ribosomes and inhibits translation

• Formula: C₄₃H₆₅N₅O₁₀
• Purezza: Min. 95%
• Colore e forma: White Powder
• Peso molecolare: 812 g/mol

Telithromycin - 98%

CAS: 191114-48-4

Ketolide; binds bacterial ribosomes and inhibits translation

• Formula: C₄₃H₆₅N₅O₁₀
• Purezza: Min. 95%
• Colore e forma: Powder
• Peso molecolare: 812 g/mol